Synonyms
Definition
Acinar cystic transformation (ACT) is a nonneoplastic cystic lesion of the pancreas lined by acinar, ductal, and/or metaplastic epithelium.
Clinical Features
Incidence
This lesion is extremely rare, with less than 50 cases reported in the literature.
Age
ACT is observed in a broad age range (9–83 years) with a mean age of 43–52 years (Bergmann et al. 2014; Khor et al. 2012; McEvoy et al. 2010; Singhi et al. 2013; Wang et al. 2016; Zamboni et al. 2002; Zhang et al. 2017).
Sex
ACT occurs more frequently in females than in males with a ratio of about 3:1 (Bergmann et al. 2014; Khor et al. 2012; McEvoy et al. 2010; Singhi et al. 2013; Wang et al. 2016; Zamboni et al. 2002; Zhang et al. 2017).
Site
The pancreatic head is more frequently affected than the body-tail (3:2); a diffuse involvement of the pancreas is described as well.
Treatment
The clinical management of ACT is controversial. Since it is a benign lesion, it can be cured by surgical...
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References and Further Reading
Bergmann, F., Aulmann, S., Welsch, T., Herpel, E., Werner, J., Schirmacher, P., et al. (2014). Molecular analysis of pancreatic acinar cell cystadenomas: Evidence of a non-neoplastic nature. Oncology Letters, 8(2), 852–858. https://doi.org/10.3892/ol.2014.2163.
Khor, T. S., Badizadegan, K., Ferrone, C., Fernández-del Castillo, C., Desai, G. S., Saenz, A., et al. (2012). Acinar cystadenoma of the pancreas: A clinicopathologic study of 10 cases including multilocular lesions with mural nodules. American Journal of Surgical Pathology, 36(11), 1579–1591. https://doi.org/10.1097/PAS.0b013e318265fa4b.
McEvoy, M. P., Rich, B., Klimstra, D., Vakiani, E., & La Quaglia, M. P. (2010). Acinar cell cystadenoma of the pancreas in a 9-year-old boy. Journal of Pediatric Surgery, 45(5), e7–e9. https://doi.org/10.1016/j.jpedsurg.2010.02.043.
Singhi, A. D., Norwood, S., Liu, T. C., Sharma, R., Wolfgang, C. L., Schulick, R. D., et al. (2013). Acinar cell cystadenoma of the pancreas: A benign neoplasm or non-neoplastic ballooning of acinar and ductal epithelium? American Journal of Surgical Pathology, 37(9), 1329–1335. https://doi.org/10.1097/PAS.0b013e3182a1ad72.
Wang, G., Ji, L., Qu, F.-Z., Li, L., Cao, C.-L., Li, Z.-B., et al. (2016). Acinar cell cystadenoma of the pancreas: A retrospective analysis of ten-year experience from a single academic institution. Pancreatology: Official Journal of the International Association of Pancreatology (IAP) … [et al.], 16(4), 625–631. https://doi.org/10.1016/j.pan.2016.03.020.
Zamboni, G., Terris, B., Scarpa, A., Kosmahl, M., Capelli, P., Klimstra, D. S., et al. (2002). Acinar cell cystadenoma of the pancreas: A new entity? American Journal of Surgical Pathology, 26(6), 698–704. https://doi.org/10.1097/00000478-200206000-00002.
Zhang, X., Zhu, H., Yang, X., Adsay, V. N., & Jain, D. (2017). Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same? Pathology Research and Practice, 213(8), 997–1001. https://doi.org/10.1016/j.prp.2017.03.013.
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Esposito, I., Haeberle, L. (2021). Acinar Cystic Transformation of the Pancreas. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5521-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5521-1
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