Age-Related Changes

Esposito, Irene; Haeberle, Lena

doi:10.1007/978-3-319-28845-1_5523-1

Irene Esposito³ &
Lena Haeberle³

Part of the book series: Encyclopedia of Pathology ((EP))

17 Accesses

Synonyms

Fatty Infiltration; Fatty replacement; Steatosis

Definition

Morphological changes related to aging, usually without clinical relevance, mostly being represented by lipomatosis and fibrosis. Lipomatous atrophy due to long-lasting ductal obstruction (Shimizu et al., 1997) or genetic diseases (Levin et al., 2015; Mandavdhare et al., 2017) and fibrosis due to obstruction or chronic pancreatitis do not fit to this definition (Esposito et al., 2020).

Clinical Features

Incidence
According to autopsy series performed in individuals without known pancreatic pathology, the frequency of clinically not relevant changes, such as lipomatosis, is quite high, being detected in about 94% of the analyzed cases (Stamm, 1984). Imaging studies based on endoscopic ultrasound have shown an overall prevalence of lipomatosis of 27.8% and of 100% in the group of individuals older than 90 years (Choi et al., 2010). Another frequent change is patchy fibrosis, which was observed in 92% of the cases in...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References and Further Reading

Choi, C. W., Kim, G. H., Kang, D. H., Kim, H. W., Kim, D. U., Heo, J., et al. (2010). Associated factors for a hyperechogenic pancreas on endoscopic ultrasound. World Journal of Gastroenterology, 16(34), 4329–4334. https://doi.org/10.3748/wjg.v16.i34.4329.
Article PubMed PubMed Central Google Scholar
Esposito, I., Hruban, R. H., Verbeke, C., Terris, B., Zamboni, G., Scarpa, A., et al. (2020). Guidelines on the histopathology of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American pancreatic association, the Japan pancreas society, and the European pancreatic Club. Pancreatology, 20(4), 586–593. https://doi.org/10.1016/j.pan.2020.04.009.
Article PubMed Google Scholar
Glaser, J., & Stienecker, K. (2000). Pancreas and aging: A study using ultrasonography. Gerontology, 46(2), 93–96. https://doi.org/10.1159/000022141.
Article CAS PubMed Google Scholar
Klöppel, G., Detlefsen, S., & Feyerabend, B. (2004). Fibrosis of the pancreas: The initial tissue damage and the resulting pattern. Virchows Archiv, 445(1), 1–8. https://doi.org/10.1007/s00428-004-1021-5.
Article CAS PubMed Google Scholar
Levin, T. L., Mäkitie, O., Berdon, W. E., & Lachman, R. S. (2015). Shwachman-Bodian-diamond syndrome: Metaphyseal chondrodysplasia in children with pancreatic insufficiency and neutropenia. Pediatric Radiology, 45(7), 1066–1071. https://doi.org/10.1007/s00247-014-3231-6.
Article PubMed Google Scholar
Mandavdhare, H. S., Kumar, A., Sharma, V., & Rana, S. S. (2017). Pancreatic lipomatosis in cystic fibrosis: Rare manifestation of an uncommon disease. Intractable & Rare Diseases Research, 6(2), 150–151. https://doi.org/10.5582/irdr.2017.01008.
Article Google Scholar
Olsen, T. S. (1978). Lipomatosis of the pancreas in autopsy material and its relation to age and overweight. Acta Pathologica et Microbiologica Scandinavica. Section A: Pathology, 86a(5), 367–373. https://doi.org/10.1111/j.1699-0463.1978.tb02058.x.
Article CAS Google Scholar
Schmitz-Moormann, P., Pittner, P. M., & Heinze, W. (1981). Lipomatosis of the pancreas. A morphometrical investigation. Pathology, Research and Practice, 173(1–2), 45–53. https://doi.org/10.1016/s0344-0338(81)80006-4.
Article CAS PubMed Google Scholar
Shimizu, M., Hirokawa, M., Matsumoto, T., Iwamoto, S., & Manabe, T. (1997). Fatty replacement of the pancreatic body and tail associated with leiomyosarcoma of the pancreatic head. Pathology International, 47(9), 633–636. https://doi.org/10.1111/j.1440-1827.1997.tb04554.x.
Article CAS PubMed Google Scholar
Stamm, B. H. (1984). Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: A systematic study of 112 autopsies in patients without known pancreatic disease. Human Pathology, 15(7), 677–683. https://doi.org/10.1016/s0046-8177(84)80294-4.
Article CAS PubMed Google Scholar

Download references

Author information

Authors and Affiliations

Institute of Pathology, Heinrich-Heine University and University Hospital of Duesseldorf, Duesseldorf, Germany
Irene Esposito & Lena Haeberle

Authors

Irene Esposito
View author publications
You can also search for this author in PubMed Google Scholar
Lena Haeberle
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Irene Esposito .

Editor information

Editors and Affiliations

NIJMEGEN, The Netherlands
J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

About this entry

Cite this entry

Esposito, I., Haeberle, L. (2021). Age-Related Changes. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5523-1

Download citation

DOI: https://doi.org/10.1007/978-3-319-28845-1_5523-1
Received: 10 July 2020
Accepted: 24 November 2020
Published: 23 June 2021
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-28845-1
Online ISBN: 978-3-319-28845-1
eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics