Definition
Malignant neoplasm arising from urothelium that shows pronounced ability for divergent differentiation with invasion beyond the basement membrane.
Clinical Features
Incidence
Urothelial carcinoma represents the seventh most common cancer, and, among these, about 30% present with invasive disease.
Age
The median patient age is 65–70 years, with age distribution from pediatric (uncommon) to old age.
Sex
It is most common in male patients, with a male-to-female ratio of 3–4:1.
Site
The bladder represents the most common site of invasive urothelial carcinoma (90%) among the urinary tract organs. The involvement of upper urinary tract organs occurs in about 10% of the cases. The involvement of urethra is uncommon; it occurs mainly in old patients with previous urothelial carcinoma of the bladder or upper urinary tract organs (Fig. 1). Multifocal...
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Raspollini, M.R., Lopez-Beltran, A. (2020). Urothelial Carcinoma, Invasive. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5563-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5563-1
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