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Benign Squamous Lesions

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 4 Accesses

Condyloma Acuminatum

Definition

They are benign, flat, or verruciform lesions caused by low-risk HPV.

Clinical Features

They may be asymptomatic and incidental. If at the introitus, they may present with itching and irritation.

  • Incidence

    They are rare in the vagina.

  • Age

    Generally seen in young, sexually active adults.

  • Site

    Lower vagina and introitus.

  • Treatment

    Nonsurgical treatment including observation, local excision, topical imiquimod, and laser ablation.

Outcome

Multiple recurrences are not common (Widschwendter et al. 2019).

Macroscopy

Hyperkeratotic flat or raised lesions.

Microscopy

Acanthosis, blunt papillomatosis, tiered parakeratosis, hypergranulosis, hyperkeratosis, and koilocytosis can be seen. The prominence of the features correlates with the age of the lesion, being more prominent in younger lesions.

Immunophenotype

P16 staining is nonblock. Low-risk HPV (usually HPV6 and HPV11) can be detected by PCR or in situ hybridization (Pirog 2015).

Differential Diagnosis

None

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References

  • Pirog, E. C. (2015). Immunohistochemistry and in situ hybridization for the diagnosis and classification of squamous lesions of the anogenital region. Seminars in Diagnostic Pathology, 32(5), 409–418.

    Article  Google Scholar 

  • Widschwendter, A., Böttcher, B., Riedl, D., Coban, S., Mutz-Dehbalaie, I., Matteucci Gothe, R., Ciresa-König, A., Marth, C., & Fessler, S. (2019). Recurrence of genitals warts in pre-HPV vaccine era after laser treatment. Archives of Gynecology and Obstetrics, 300, 661–668.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cellular Pathology, East Suffolk and North Essex NHS Foundation Trust, Ipswich, UK

    Jason Wong

Authors
  1. Jason Wong
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Corresponding author

Correspondence to Jason Wong .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Wong, J. (2022). Benign Squamous Lesions. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5593-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5593-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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