Description
In the previous edition of the World Health Organization (WHO) Classification of Tumors of Female Reproductive Organs (4th Edition, 2014), tumors of the uterine cervix were classified largely by morphologic appearance, with little emphasis on biologic or etiologic associations. This was particularly evident in the adenocarcinoma category. For example, mucinous adenocarcinomas that exhibited goblet cells were termed mucinous adenocarcinoma – intestinal type, and those that exhibited signet ring cells were termed mucinous adenocarcinoma – signet ring cell type, regardless of the underlying human papillomavirus (HPV) status. In addition, vague descriptions made application to daily practice difficult. The endometrioid carcinoma category included those truly endometrioid tumors that arose from endometriosis as well as usual (conventional) HPV-associated tumors with mucin depletion that merely mimicked the appearance of an endometrioid carcinoma.
In response to these issues, the...
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References
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Hoang, L. (2022). Who Classification of Tumors of the Uterine Cervix. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5611-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5611-1
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