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Adenocarcinoma and Precursors, Pathology of the Cervix

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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HPV-Associated Adenocarcinoma In Situ (AIS)

Synonyms

High-grade cervical glandular intraepithelial neoplasia

Definition

Noninvasive glandular dysplasia of the cervix, caused by human papillomavirus (HPV) infection (most commonly HPV 16 and 18)

Clinical Features

  • Incidence

    The incidence of AIS in the United States is approximately 100–700 per 100,000 women (Sherman et al. 2005).

  • Age

    The mean age is 35 years.

  • Sex

    Female

  • Site

    AIS usually originates in the squamocolumnar junction and proximal endocervical canal, although some lesions can be located high up in the endocervical canal or deep in the endocervical glands. Approximately 10–15% of patients will have multifocal or “skip” lesions.

  • Treatment

    Patients diagnosed with AIS on biopsy or endocervical curettage (ECC) will require an excision (cold knife cone or loop-electrosurgical excision procedure [LEEP]) to remove the lesion and exclude invasive disease. A cold knife cone is wider and deeper than a LEEP and provides for better margin...

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Authors and Affiliations

  1. Anatomical Pathology, Vancouver General Hospital, Vancouver, BC, Canada

    Lynn Hoang

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  1. Lynn Hoang
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Correspondence to Lynn Hoang .

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  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Hoang, L. (2022). Adenocarcinoma and Precursors, Pathology of the Cervix. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5614-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5614-1

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