Metaplastic Papillary Lesion
Definition
Metaplastic papillary lesion is an uncommon but distinctive intraluminal papillary epithelial proliferation.
Clinical Features
Incidence
This lesion is extremely rare (case reports only) (Bartnik et al. 1989).
Age
This lesion is almost exclusively detected in pregnant and postpartum women (Saffos et al. 1980).
Site
Fallopian tube
Clinical Presentation
This lesion is an incidental finding (Jang et al. 2017).
Treatment
Not needed
Outcome
The behavior appears benign (Solomon et al. 2003).
Macroscopy
This lesion represents a microscopic finding in a grossly normal fallopian tube (Pang 1999).
Microscopy
The lesions appear similar to serous borderline tumors of the ovary, with proliferation of atypical epithelial cells, cellular budding, and the presence of abundant eosinophilic cytoplasm in most of the lesional cells, some of the cells contain mucin. Rare mitotic figures may be present (Saffos et al. 1980).
Immunophenotype
The lesional cells are...
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References and Further Reading
Bartnik, J., Powell, W. S., Moriber-Katz, S., & Amenta, P. S. (1989). Metaplastic papillary tumor of the fallopian tube. Case report, immunohistochemical features and review of the literature. Archives of Pathology & Laboratory Medicine, 113, 545–547.
Chawla, N., Kudesia, S., Azad, S., Singhal, M., & Rai, S. M. (2009). Salpingitis isthmica nodosa. Indian Journal of Pathology & Microbiology, 52, 434–435.
Cheung, A. N., Young, R. H., & Scully, R. E. (1994). Pseudocarcinomatous hyperplasia of the fallopian tube associated with salpingitis. A report of 14 cases. The American Journal of Surgical Pathology, 18, 1125–1130.
Darwish, A. M., Amin, A. F., & Mohammad, S. A. (2003). Laparoscopic management of paratubal and paraovarian cysts. Journal of the Society of Laparoendoscopic Surgeons, 7, 101–106.
Gupta, S., Singh, P., Bala, J., Mushtaq, D., & Goyal, A. (2012). Pseudocarcinomatous hyperplasia of the fallopian tubes which was associated with female genital tract tuberculosis, histologically mimicking tubal adenocarcinoma: A diagnostic challenge. Journal of Clinical and Diagnostic Research, 6, 1419–1421.
Jang, M. I., Sung, J. Y., Kim, J. Y., & Kim, H. S. (2017). Clinicopathological characteristic of metaplastic papillary tumor of the fallopian tube. Anticancer Research, 37, 3696–3701.
Jenkins, C. S., Williams, S. R., & Schmidt, G. E. (1993). Salpingitis isthmica nodosa: A review of the literature, discussion of clinical significance, and consideration of patient management. Fertility and Sterility, 60, 599–607.
Kiselli, M., Caglar, G. S., Cengiz, S. D., et al. (2012). Clinical diagnosis and complications of paratubal cysts: Review of the literature and report of uncommon presentations. Archives of Gynecology and Obstetrics, 25, 1563–1569.
Kolin, D. L., & Nucci, M. R. (2019). Fallopian tube neoplasia and mimics. Surgical Pathology, 12, 457–479.
Maymudar, B., Henderson, P. H., III, & Sample, E. (1983). Salpingitis isthmica nodosa: A high-risk factor for tubal pregnancy. Obstetrics and Gynecology, 62, 73–78.
Mc Comb, P. F., & Rowe, T. C. (1989). Salpingitis isthmica nodosa: Evidence it is a progressive disease. Fertility and Sterility, 51, 542–545.
Medeiros, F., & Bell, D. A. (2010). Pseudoneoplastic lesions of the female genital tract. Archives of Pathology & Laboratory Medicine, 134, 393–403.
Muolokwu, E., Sanchez, J., Bercaw, J. L., et al. (2011). The incidence and surgical management of paratubal cysts in a pediatric and adolescent population. Journal of Pediatric Surgery, 46, 2161–2163.
Pang, L. C. (1999). Hydrosalpinx due to asymptomatic bilateral tubal pregnancies associated with metaplastic papillary tumor of the fallopian tube. Southern Medical Journal, 92, 725–727.
Saffos, R. O., Rhatigan, R. M., & Scully, R. E. (1980). Metaplastic papillary tumor of the fallopian tube: A distinctive lesion of pregnancy. American Journal of Clinical Pathology, 74, 232–236.
Samaha, M., & Woodruff, J. D. (1985). Paratubal cysts: Frequency, histogenesis, and associated clinical features. Obstetrics and Gynecology, 65, 691–694.
Scully, R. E., Young, R. H., & Clement, P. B. (1998a). Tumors of the broad ligament and other uterine ligaments (pp. 499–511). Washington, DC: Armed Forces Institute of Pathology.
Scully, R. E., Young, R. H., & Clement, P. B. (1998b). Atlas of tumor pathology. Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament (3rd ed.). Washington, DC: AFIP.
Yanai, Y. I., Siriaunkgul, S., & Silverberg, S. G. (1995). Mucosal epithelial proliferation of the fallopian tube: A particular association with ovarian serous tumor of low malignant potential? International Journal of Gynecological Pathology, 14, 107–113.
Solomon, A. C., Chen, P. J., & LiVolsi, V. A. (2003). Pathologic quiz case: An incidental finding in the fallopian tube. Fallopian tube, left, tubal ligation: Metaplastic papillary tumor of fallopian tube. Archives of Pathology & Laboratory Medicine, 127, e363364.
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Alvarado-Cabrero, I. (2022). Tumor-Like Lesions and Cysts, Pathology of the Fallopian Tube. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5642-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5642-1
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