Tumor-Like Lesions, Pathology of the Ovary

Daaboul, Fayez

doi:10.1007/978-3-319-28845-1_5670-1

Fayez Daaboul³

Part of the book series: Encyclopedia of Pathology ((EP))

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Corpus Luteum Cyst

Definition

Corpus luteum cyst is a nonneoplastic lesion arising from physiological process; its enlargement of cystic corpus luteum is over 3 cm.

Clinical Features

Incidence
Corpus luteum cyst is common diagnosis.
Age and Sex
The frequency of the corpus luteum cysts is more common in reproductive age women. They are rare in the neonatal age and would usually follow sporadic ovulation in a postmenopausal women.
Site
Corpus luteum cyst is an ovarian lesion.
Treatment
Corpus luteum cysts are usually treated by monitoring as most of them will regress spontaneously within 2 months. Resection is recommended if the patient has symptoms of ovarian torsion or rupture (Lee et al. 2017).
Outcome
Most cases will regress spontaneously (Minelli 1996).

Macroscopy

Corpus luteum cysts are usually solitary, ranging in size from 3 to 8 cm in diameter and characterized by yellow, convoluted wall. The cyst is filled with hemorrhagic fluid.

Microscopy

Corpus luteum cysts are characterized...

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References and Further Reading

Asotra, S., & Gupta, N. (2014). Fibromatosis of the ovary. Indian Journal of Cancer, 51(4), 505. https://doi.org/10.4103/0019-509X.175335. PMID: 26842178.
Article CAS PubMed Google Scholar
Barbieri, R. L., & Hornstein, M. D. (1988). Hyperinsulinemia and ovarian hyperandrogenism. Cause and effect. Endocrinology and Metabolism Clinics of North America, 17(4), 685–703. PMID: 3058472.
Article CAS PubMed Google Scholar
Barclay, D. L., Leverich, E. B., & Kemmerly, J. R. (1969). Hyperreactio luteinalis: postpartum persistence. American Journal of Obstetrics and Gynecology, 105(4), 642–644. PMID: 4310018.
CAS PubMed Google Scholar
Bechtel, M., & Schneider, G. T. (1956). Ovarian cortical stromal hyperplasia. Obstetrics and Gynecology, 8(6), 713–719. PMID: 13378757.
CAS PubMed Google Scholar
Brown, D. L., Henrichsen, T. L., Clayton, A. C., Hudson, S. B., Coddington, C. C., 3rd, & Vella, A. (2009). Ovarian stromal hyperthecosis: Sonographic features and histologic associations. Journal of Ultrasound in Medicine, 28(5), 587–593. https://doi.org/10.7863/jum.2009.28.5.587. PMID: 19389897.
Article PubMed Google Scholar
Burandt, E., & Young, R. H. (2014). Pregnancy luteoma: A study of 20 cases on the occasion of the 50th anniversary of its description by Dr. William H. Sternberg, with an emphasis on the common presence of follicle-like spaces and their diagnostic implications. The American Journal of Surgical Pathology, 38(2), 239–244. https://doi.org/10.1097/PAS.0000000000000100. PMID: 24335664.
Article PubMed Google Scholar
Clement, P. B. (1993). Tumor-like lesions of the ovary associated with pregnancy. International Journal of Gynecological Pathology, 12(2), 108–115. https://doi.org/10.1097/00004347-199304000-00004. PMID: 8463033.
Article CAS PubMed Google Scholar
Clement, P. B., & Scully, R. E. (1980). Large solitary luteinized follicle cyst of pregnancy and puerperium: A clinicopathological analysis of eight cases. The American Journal of Surgical Pathology, 4(5), 431–438. https://doi.org/10.1097/00000478-198010000-00003. PMID: 7435772.
Article CAS PubMed Google Scholar
Colecchia, M., Nistal, M., Gonzalez-Peramato, P., Carmignani, L., Salvioni, R., Nicolai, N., & Regadera, J. (2007). Leydig cell tumor and hyperplasia: A review. Analytical and Quantitative Cytology and Histology, 29(3), 139–147. PMID: 17672373.
PubMed Google Scholar
Damodaran, S., Mahmood, T., Nawroz, I., & Swaminathan, K. (2011). Ovarian stromal hyperplasia and hyperthecosis: An unusual case of post-menopausal hirsutism. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 158(1), 114–115. https://doi.org/10.1016/j.ejogrb.2011.04.014. Epub 2011 May 23. PMID: 21601981.
Article PubMed Google Scholar
Delibasi, T., Erdogan, M. F., Serinsöz, E., Kaygusuz, G., Erdogan, G., & Sertçelik, A. (2007). Ovarian hilus-cell hyperplasia and high serum testosterone in a patient with postmenopausal virilization. Endocrine Practice, 13(5), 472–475. https://doi.org/10.4158/EP.13.5.472. PMID: 17872348.
Article PubMed Google Scholar
Edell, H., Shearkhani, O., Rahmani, M. R., & Kung, R. C. (2018). Incidentally found hyperreactio luteinalis in pregnancy. Radiol Case Reports, 13(6), 1220–1223. https://doi.org/10.1016/j.radcr.2018.08.022. PMID: 30258510; PMCID: PMC6148833.
Article Google Scholar
Fukunishi, H., Murata, K., Takeuchi, S., & Kitazawa, S. (1996). Ovarian fibromatosis with minor sex cord elements. Archives of Gynecology and Obstetrics, 258(4), 207–211. https://doi.org/10.1007/s004040050125. PMID: 8844138.
Article CAS PubMed Google Scholar
Garcia-Bunuel, R., Berek, J. S., & Woodruff, J. D. (1975). Luteomas of pregnancy. Obstetrics and Gynecology, 45(4), 407–414. PMID: 164641.
CAS PubMed Google Scholar
Haddad, A., Mulvany, N., Billson, V., & Arnstein, M. (2000). Solitary luteinized follicle cyst of pregnancy. Report of a case with cytologic findings. Acta Cytologica, 44(3), 454–458. https://doi.org/10.1159/000328498. PMID: 10834011.
Article CAS PubMed Google Scholar
He, H., Luthringer, D. J., Hui, P., Lau, S. K., Weiss, L. M., & Chu, P. G. (2008). Expression of CD56 and WT1 in ovarian stroma and ovarian stromal tumors. The American Journal of Surgical Pathology, 32(6), 884–890. https://doi.org/10.1097/PAS.0b013e3181609d59. PMID: 18425046.
Article PubMed Google Scholar
Hensleigh, P. A., & Woodruff, J. D. (1978). Differential maternal-fetal response to androgenizing luteoma or hyperreactio luteinalis. Obstetrical & Gynecological Survey, 33(4), 262–271. https://doi.org/10.1097/00006254-197804000-00016. PMID: 205819.
Article CAS Google Scholar
Honoré, L. H., & O’Hara, K. E. (1979). Ovarian hilus cell heterotopia. Obstetrics and Gynecology, 53(4), 461–464. PMID: 440648.
PubMed Google Scholar
Judd, H. L., Scully, R. E., Atkins, L., Neer, R. M., & Kliman, B. (1970). Pure gonadal dysgenesis with progressive hirsutism. The New England Journal of Medicine, 282(16), 881–885. https://doi.org/10.1056/NEJM197004162821601. PMID: 4314043.
Article CAS PubMed Google Scholar
Judd, H. L., Benirschke, K., De Vane, G., Reuter, S. R., & Yen, S. S. (1973). Maternal virilization developing during a twin pregnancy demonstration of excess ovarian androgen production associated with theca lutein cysts. The New England Journal of Medicine, 288(3), 118–122. https://doi.org/10.1056/NEJM197301182880302. PMID: 4344443.
Article CAS PubMed Google Scholar
Khalbuss, W. E., & Dipasquale, B. (2006). Massive ovarian edema associated with ovarian serous cystadenoma: A case report and review of the literature. International Journal of Gynecological Cancer, 16(Suppl 1), 326–330. https://doi.org/10.1111/j.1525-1438.2006.00368.x. PMID: 16515615.
Article PubMed Google Scholar
Kommoss, F., Oliva, E., Bhan, A. K., Young, R. H., & Scully, R. E. (1998). Inhibin expression in ovarian tumors and tumor-like lesions: An immunohistochemical study. Modern Pathology, 11(7), 656–664. PMID: 9688187.
CAS PubMed Google Scholar
Lee, M. S., Moon, M. H., Woo, H., Sung, C. K., Jeon, H. W., & Lee, T. S. (2017). Ruptured corpus luteal cyst: Prediction of clinical outcomes with CT. Korean Journal of Radiology, 18(4), 607–614. https://doi.org/10.3348/kjr.2017.18.4.607. Epub 2017 May 19. PMID: 28670155; PMCID: PMC5447636.
Article PubMed PubMed Central Google Scholar
Lermer, A., Villanueva, C., & Tannhauser, S. (1958). Bilateral theca lutein cysts of the ovary in a case of erythroblastosis; presentation of a case. American Journal of Obstetrics and Gynecology, 75(1), 203–206. https://doi.org/10.1016/0002-9378(58)90573-8. PMID: 13487704.
Article CAS PubMed Google Scholar
Liapi, C., & Evain-Brion, D. (1987). Diagnosis of ovarian follicular cysts from birth to puberty: A report of twenty cases. Acta Paediatrica Scandinavica, 76(1), 91–96. https://doi.org/10.1111/j.1651-2227.1987.tb10421.x. PMID: 3565008.
Article CAS PubMed Google Scholar
Lomme, M., Kostadinov, S., & Zhang, C. (2011). Large solitary luteinized follicle cyst of pregnancy and puerperium: Report of two cases. Diagnostic Pathology, 6, 3. https://doi.org/10.1186/1746-1596-6-3. PMID: 21219622; PMCID: PMC3022785.
Article PubMed PubMed Central Google Scholar
Lozoya Araque, T., Monfort Ortiz, I. R., Martín González, J. E., Jiménez García, A., Navarro Hidalgo, I., Andrade Gamarra, V., Parrell Soler, C., & Gil Raga, F. (2020). Ovarian stromal hyperplasia: A rare cause of postmenopausal hyperandrogenism. Journal of Korean Society of Menopause, 26(1), 39–43. https://doi.org/10.6118/jmm.19012. PMID: 32307950; PMCID: PMC7160587.
Article Google Scholar
Madiedo, G., Tieu, T. M., & Aiman, J. (1985). Atypical ovarian hyperthecosis in a virilized postmenopausal woman. American Journal of Clinical Pathology, 83(1), 101–107. https://doi.org/10.1093/ajcp/83.1.101. PMID: 3966429.
Article CAS PubMed Google Scholar
Minelli, L. (1996). Ovarian cysts. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 65(1), 81–89. https://doi.org/10.1016/0028-2243(95)02309-g. PMID: 8706964.
Article CAS PubMed Google Scholar
Montz, F. J., Schlaerth, J. B., & Morrow, C. P. (1988). The natural history of theca lutein cysts. Obstetrics and Gynecology, 72(2), 247–251. PMID: 2455880.
CAS PubMed Google Scholar
Nogales, F. F., Martin-Sances, L., Mendoza-Garcia, E., Salamanca, A., González-Nuñez, M. A., & Pardo Mindán, F. J. (1996). Massive ovarian oedema. Histopathology, 28(3), 229–234. https://doi.org/10.1046/j.1365-2559.1996.d01-420.x. PMID: 8729041.
Norris, H. J., & Taylor, H. B. (1967). Nodular theca-lutein hyperplasia of pregnancy (so-called “pregnancy luteoma”). A clinical and pathologic study of 15 cases. American Journal of Clinical Pathology, 47(5), 557–566. https://doi.org/10.1093/ajcp/47.5.557. PMID: 4290238.
Article CAS PubMed Google Scholar
Onderoglu, L. S., Gültekin, M., Dursun, P., Karcaaltincaba, M., Usubutun, A., Akata, D., & Ayhan, A. (2004). Bilateral ovarian fibromatosis presenting with ascites and hirsutism. Gynecologic Oncology, 94(1), 223–225. https://doi.org/10.1016/j.ygyno.2004.03.042. PMID: 15262147.
Article PubMed Google Scholar
Reijnen, C., Küsters-Vandevelde, H. V. N., Abbink, K., Zusterzeel, P. L. M., van Herwaarden, A. E., van der Laak, J. A. W. M., Massuger, L. F. A. G., Snijders, M. P. L. M., Pijnenborg, J. M. A., & Bulten, J. (2019). Quantification of Leydig cells and stromal hyperplasia in the postmenopausal ovary of women with endometrial carcinoma. Human Pathology, 85, 119–127. https://doi.org/10.1016/j.humpath.2018.10.022. Epub 2018 Nov 11. PMID: 30428390.
Article CAS PubMed Google Scholar
Roberts, C. L., & Weston, M. J. (1998). Bilateral massive ovarian edema: a case report. Ultrasound in Obstetrics & Gynecology, 11(1), 65–67. https://doi.org/10.1046/j.1469-0705.1998.11010065.x. PMID: 9511200.
Article CAS Google Scholar
Roth, L. M., Deaton, R. L., Sternberg, W. H., & Massive ovarian edema. (1979). A clinicopathologic study of five cases including ultrastructural observations and review of the literature. The American Journal of Surgical Pathology, 3(1), 11–21. https://doi.org/10.1097/00000478-197902000-00002. PMID: 534380.
Article CAS PubMed Google Scholar
Sailer, V., Huss, S., Wardelmann, E., & Müller, A. M. (2013). Massives Ovarialödem bei einem 13-jährigen Mädchen [Massive ovarian edema in a 13-year-old girl]. Pathologe, 34(6), 563–565. https://doi.org/10.1007/s00292-013-1762-5. PMID: 23649810. German.
Article CAS PubMed Google Scholar
Sasano, H., Fukunaga, M., Rojas, M., & Silverberg, S. G. (1989). Hyperthecosis of the ovary. Clinicopathologic study of 19 cases with immunohistochemical analysis of steroidogenic enzymes. International Journal of Gynecological Pathology, 8(4), 311–320. PMID: 2807712.
Article CAS PubMed Google Scholar
Schonberg, L. A. (1979). Combined pregnancy and ruptured corpus luteum cyst. American Journal of Obstetrics and Gynecology, 133(1), 106–107. https://doi.org/10.1016/0002-9378(79)90419-8. PMID: 760526.
Article CAS PubMed Google Scholar
Scurry, J., Allen, D., & Dobson, P. (1996). Ovarian fibromatosis, ascites and omental fibrosis. Histopathology, 28(1), 81–84. https://doi.org/10.1046/j.1365-2559.1996.258289.x. PMID: 8838126.
Article CAS PubMed Google Scholar
Sherer, D. M., Dalloul, M., Khoury-Collado, F., Hellman, M., Osho, J. A., Gupta, R. S., & Abulafia, O. (2006). Hyperreactio luteinalis presenting with marked hyperglycemia and bilateral multicystic adnexal masses at 21 weeks gestation. American Journal of Perinatology, 23(2), 85–88. https://doi.org/10.1055/s-2006-931910. PMID: 16506113.
Article PubMed Google Scholar
Steingold, K. A., Judd, H. L., Nieberg, R. K., Lu, J. K., & Chang, R. J. (1986). Treatment of severe androgen excess due to ovarian hyperthecosis with a long-acting gonadotropin-releasing hormone agonist. American Journal of Obstetrics and Gynecology, 154(6), 1241–1248. https://doi.org/10.1016/0002-9378(86)90706-4. PMID: 3087210.
Article CAS PubMed Google Scholar
Sternberg, W. H., & Barclay, D. L. (1966). Luteoma of pregnancy. American Journal of Obstetrics and Gynecology, 95(2), 165–184. https://doi.org/10.1016/0002-9378(66)90167-0. PMID: 4286956.
Article CAS PubMed Google Scholar
Strickler, R. C., Kelly, R. W., & Askin, F. B. (1984). Postmenopausal ovarian follicle cyst: An unusual cause of estrogen excess. International Journal of Gynecological Pathology, 3(3), 318–322. https://doi.org/10.1097/00004347-198403000-00007. PMID: 6500803.
Article CAS PubMed Google Scholar
Tazion, S., Hafeez, M., & Manzoor, R. (2020). Massive ovarian edema mimicking malignancy. Journal of the College of Physicians and Surgeons–Pakistan, 30(10), 1111–1112. https://doi.org/10.29271/jcpsp.2020.10.1111. PMID: 33143842.
Article PubMed Google Scholar
Van den Brûle, F., Bourque, J., Gaspard, U. J., & Hustin, J. F. (1994). Massive ovarian edema with androgen secretion. A pathological and endocrine study with review of the literature. Hormone Research, 41(5–6), 209–214. https://doi.org/10.1159/000183925. PMID: 7959622.
Article PubMed Google Scholar
Wajda, K. J., Lucas, J. G., & Marsh, W. L., Jr. (1989). Hyperreactio luteinalis. Benign disorder masquerading as an ovarian neoplasm. Archives of Pathology & Laboratory Medicine, 113(8), 921–925. PMID: 2667498.
CAS Google Scholar
Watkins, J. C., Lebok, P., & Young, R. H. (2020). Hyperreactio luteinalis (multiple luteinized follicle cysts): A report of 10 cases. International Journal of Gynecological Pathology, 40, 427–434. https://doi.org/10.1097/PGP.0000000000000746. Epub ahead of print. PMID: 33323862.
Article CAS Google Scholar
Young, R. H., & Scully, R. E. (1984). Fibromatosis and massive edema of the ovary, possibly related entities: A report of 14 cases of fibromatosis and 11 cases of massive edema. International Journal of Gynecological Pathology, 3(2), 153–178. https://doi.org/10.1097/00004347-198402000-00005. PMID: 6490313.
Article CAS PubMed Google Scholar
Zhang, J., Young, R. H., Arseneau, J., & Scully, R. E. (1982). Ovarian stromal tumors containing lutein or Leydig cells (luteinized thecomas and stromal Leydig cell tumors)–a clinicopathological analysis of fifty cases. International Journal of Gynecological Pathology, 1(3), 270–285. https://doi.org/10.1097/00004347-198203000-00004. PMID: 6309683.
Article CAS PubMed Google Scholar

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Wayne State University/Detroit Medical Centers, Detroit, MI, USA
Fayez Daaboul

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NIJMEGEN, The Netherlands
J.H.J.M. van Krieken

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Daaboul, F. (2022). Tumor-Like Lesions, Pathology of the Ovary. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5670-1

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DOI: https://doi.org/10.1007/978-3-319-28845-1_5670-1
Received: 06 April 2021
Accepted: 28 September 2021
Published: 21 June 2023
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-28845-1
Online ISBN: 978-3-319-28845-1
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