Definition
The sharing of alleles of certain genes and/or markers among siblings and related individuals
Introduction
The concept of allele sharing is derived from the Mendelian law of segregation of alleles. Two siblings (sibs) can exhibit allele sharing which is identity by descent (IBD) due to inheritance from a common parent. Sharing of allele can also be incidental when the reason for sharing is not known and is known as identity by state (IBS). According to Mendelian segregation rules, the probability that pair of siblings would share both marker alleles = 0.25, one marker allele = 0.5, and zero marker allele = 0.25. This follows the Mendelian expected ratio of 1:2:1.
Allele Sharing Methods
These are popular nonparametric analytical methods used for the study of complex disorders. Affected sib-pair (ASP) analysis is one of the common and simplest of allele sharing methods (Fig. 1). If affected siblings or relatives share...
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References
Callegaro, A., Meulenbelt, I., Kloppenburg, M., Slagboom, P. E., & Houwing-Duistermaat, J. J. (2010). Allele-sharing statistics using information on family history. Annals of Human Genetics, 74, 547–554.
DeVisser, M. C. H., Minkelen, R. V., Heijer, M. D., Eikenboom, J., Vos, H. L., Slagboom, P. E., et al. (2013). Genome-wide linkage scan in affected sibling pairs identifies novel susceptibility region for venous thromboembolism: Genetics in familial thrombosis study. Journal of Thrombosis and Haemostasis, 11, 1472–1484.
Fingerlin, T. E., Boehnke, M., & Abecasis, G. R. (2004). Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. American Journal of Human Genetics, 74, 432–443.
Kong, A., & Cox, N. J. (1997). Allele-sharing models: LOD scores and accurate linkage tests. American Journal of Human Genetics, 61, 1179–1188.
Kruglyak, L., Daly, M. J., Reeve-Daly, M. P., & Lander, E. S. (1996). Parametric and nonparametric linkage analysis: A unified multipoint approach. American Journal of Human Genetics, 58, 1347–1363.
Lander, E. S., & Schork, N. J. (1994). Genetic dissection of complex traits. Science, 267, 2037–2048.
Prahalad, S., Ryan, M. H., Shear, E. S., Thompson, S. D., Giannini, E. H., & Glass, D. N. (2000). Linkage to HLA demonstrated by allele sharing in affected sibpairs. Arthritis and Rheumatism, 43(10), 2335–2338.
Risch, N. (1990). Linkage strategies for genetically complex traits. II. The power of affected relative pairs. American Journal of Human Genetics, 46, 229–241.
Whittemore, A. S., & Halpern, J. (1994). A class of tests for linkage using affected pedigree members. Biometrics, 50, 118–127.
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Sharma, A. (2018). Allele Sharing. In: Vonk, J., Shackelford, T. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. https://doi.org/10.1007/978-3-319-47829-6_46-1
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DOI: https://doi.org/10.1007/978-3-319-47829-6_46-1
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