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Adverse Drug Reactions, Intoxications and Interactions of Neuropsychotropic Medications

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NeuroPsychopharmacotherapy

Abstract

Any medication has desirable effects (e.g., alleviation of depressive symptoms) and may produce undesirable, unintended effects (e.g., headache or vomiting) which are called ‘adverse reactions’ or ‘adverse drug reactions’ (ADRs). ADRs can be ‘severe’ / ‘serious’ and have to be differentiated from ‘side effects’ and ‘adverse events.’ Definitions for these terms are given in this chapter. Many ADRs can be explained by the pharmacologic target(s) of the prescribed medication. This chapter gives a comprehensive review of these molecular target-based ADRs. To emphasize, some ADRs cannot be explained yet in sufficient detail by the pharmacologic target profile of the prescribed drug. Fortunately, we live in a great era with respect to wealth of and ease of access to information (i.e., the Internet). As no single individual can hold all the ADR information currently available and as it is not advisable to rely on a single database only, this chapter also contains a comprehensive description of available databases on ADRs, pharmacogenetic profiles of drug metabolism, drug interactions – including pharmacogenetic ones – and toxicologic information on medications.

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Conflicts of Interest

Christoph Hiemke is one of the editors of the commercially available database www.psiac.de. Sabine Bischinger and Gerald Zernig declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Psychiatry 1, Medical University of Innsbruck, Innsbruck, Austria

    Gerald Zernig

  2. Hospital Pharmacy, University Hospital of Innsbruck, Innsbruck, Austria

    Sabine Bischinger

  3. Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany

    Christoph Hiemke

Authors
  1. Gerald Zernig
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  2. Sabine Bischinger
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  3. Christoph Hiemke
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Corresponding author

Correspondence to Gerald Zernig .

Editor information

Editors and Affiliations

  1. Dept Psychiatry , Psychosomatics & Psychotherapy, University of Würzburg, Medical School Clinical Neurochemistry, Würzburg, Germany

    Peter Riederer

  2. Inst für Psychologische Medizin, Haag, Bayern, Germany

    Gerd Laux

  3. Fujita Health University School Medicine, Toyoake, Aichi, Japan

    Toshiharu Nagatsu

  4. Center Translational Res Neurol Diseases, Dalian Med Uni Shanghai Inst Health Sc Center Translational Res Neurol Diseases, Dalian, China

    Weidong Le

  5. Würzburg, Bayern, Germany

    Christian Riederer

Section Editor information

  1. Center of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany

    Peter Riederer

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Zernig, G., Bischinger, S., Hiemke, C. (2020). Adverse Drug Reactions, Intoxications and Interactions of Neuropsychotropic Medications. In: Riederer, P., Laux, G., Nagatsu, T., Le, W., Riederer, C. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-56015-1_8-1

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  • DOI: https://doi.org/10.1007/978-3-319-56015-1_8-1

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