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Pediatric Surgery pp 1–11Cite as

Heart Transplantation

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Abstract

Improvements in the care of infants and children with congenital heart disease and cardiomyopathy have led to an increased number of children surviving with advanced heart failure. The advent of modern mechanical circulating support options in children has changed the outcome of many patients who otherwise would have succumbed while waiting for heart transplantation. As a result, more children with end-stage heart failure are being referred for heart transplantation. Outcomes after pediatric heart transplantation have improved over the past decades. The most common indications for pediatric heart transplantation include congenital heart disease and cardiomyopathy. Current median graft survival ranges from 13 to 22 years. Common morbidities include infection, rejection, renal dysfunction, coronary allograft vasculopathy, and posttransplant lymphoproliferative disease.

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References

  • Backer CL, Zales VR, Idriss FS, et al. Heart transplantation in neonates and in children. J Heart Lung Transplant. 1992;11:311–9.

    CAS  PubMed  Google Scholar 

  • Bailey LL, Razzouk AJ, Wang N, et al. Bless the babies: one hundred fifteen late survivors of heart transplantation during the first year of life. J Thorac Cardiovasc Surg. 1993;105:805–15.

    Article  CAS  Google Scholar 

  • Bearl DW. Ethical issues in access, listing and regulation of pediatric heart transplantation. Transl Pediatr. 2019;8(4):278–83.

    Article  Google Scholar 

  • Bove EL. Transplantation after first-stage reconstruction for hypoplastic left heart syndrome. Ann Thorac Surg. 1991;52:701–7.

    Article  CAS  Google Scholar 

  • Cooper DKC, Taniguchi S. Heterotopic heart transplantation – indications, surgical techniques and special considerations. In: The Transplantation and replacement of thoracic organs. Dordrecht: Springer; 1996. p. 353–65.

    Chapter  Google Scholar 

  • D’Addese L, Joong A, Burch M, et al. Pediatric heart transplantation in the current era. Curr Opin Pediatr. 2019;31(5):583–91.

    Article  Google Scholar 

  • Del Nido PJ, Bailey LL, Kirklin JK. Surgical techniques in pediatric heart transplantation. ISHLT Monogr Ser. 2007;2:83–102.

    Google Scholar 

  • Dipchand AI, Kirk R, Edwards LB, et al. The registry of the International Society for Heart and Lung Transplantation: sixteenth official pediatric heart transplantation report – 2013; focus theme: age. J Heart Lung Transplant. 2013;32:979–88.

    Article  Google Scholar 

  • Foreman C, Gruenwald C, West L. ABO-incompatible heart transplantation: a perfusion strategy. Perfusion. 2004;19:69–72.

    Article  CAS  Google Scholar 

  • Fraser CD 3rd, Grimm JC, Zhou X, et al. Children’s heart assessment tool for transplantation (CHAT) score: a novel risk score predicts survival after pediatric heart transplantation. World J Pediatr Congenit Heart Surg. 2019;10(3):296–303.

    Article  Google Scholar 

  • Iyer A, Gao L, Doyle A, Kumarasinghe G, Jabbour A, Hicks M, Jansz P, Dhital K, Macdonald P. Cardiac transplantation using hearts from donation after circulatory death (DCD) donors – a viable source of organs? J Heart Lung Transplant. 2013;32:S247–8.

    Article  Google Scholar 

  • John MM, Razzouk AJ, Chinnock RE, et al. Primary transplantation for congenital heart disease in the neonatal period: long-term outcomes. Ann Thorac Surg. 2019;108(6):1857–64.

    Article  Google Scholar 

  • Lund LH, Rahmel AO, Stehlik J. The registry of the International Society of Heart and Lung Transplantation: thirtieth adult lung and heart-lung transplant report. J Heart Lung Transplant. 2013;32:965–78.

    Article  Google Scholar 

  • Magnetta DA, Godown J, West S, et al. Impact of the 2016 revision of US pediatric heart allocation policy on waitlist characteristics and outcomes. Am J Transplant. 2019;19(12):3276–83.

    Article  Google Scholar 

  • Mao CY, Mahle WT. A new era in pediatric heart allocation: keeping our house in order. Am J Transplant. 2019;19(12):3219–20.

    Article  Google Scholar 

  • Mehra MR, Kobashigawa J, Starling R, Russell S, Uber PA, Parameshwar J, Mohacsi P, Augustine S, Aaronson K, Barr M. Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates. J Heart Lung Transplant. 2006;25:1024–42.

    Article  Google Scholar 

  • Michielon G, Parisi F, Di Carlo D, et al. Orthotopic heart transplantation for failing Fontan circulation. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2004;7:56–64.

    Article  Google Scholar 

  • Minami K, von Knyphausen E, Niino T, Blanz U, Tenderich G, Wlost S, Meyer H, Korfer R. Long-term results of pediatric heart transplantation. Ann Thorac Surg. 2005;11:386–90.

    Google Scholar 

  • Murtuza B, Dedieu N, Vazquez A, Fenton M, Burch M, Hsia TY, Tsang VT, Kostolny M. Results of orthotopic heart transplantation for failed palliation of hypoplastic left heart. Eur J Cardiothorac Surg. 2012;1:1–7.

    Google Scholar 

  • Raisky O, Tamisier D, Vouhe PR. Orthotopic heart transplantation for congenital heart defects: anomalies of the systemic venous return. Multimedia Man Cardiothorac Surg. 2006. https://doi.org/10.1510/mmcts.2005.001578.

  • Raissadati A, Pihkala J, Jahnukainen T, et al. Late outcome after paediatric heart transplantation in Finland. Interact Cardiovasc Thorac Surg. 2016;23(1):18–25.

    Article  Google Scholar 

  • Rohde S, Antonides CFJ, Dalinghaus M, et al. Clinical outcomes of paediatric patients supported by the Berlin Heart EXCOR: a systematic review. Eur J Cardiothorac Surg. 2019;56(5):830–9.

    Article  Google Scholar 

  • Tjan TDT, Scheld HH, Schmid C. Heart transplantation after Fontan’s procedure with bilateral cavopulmonary connections. Thorac Cardiovasc Surg. 2006;54:210–2.

    Article  CAS  Google Scholar 

  • West LJ, Pollock-Barziv SM, Dipchand AI, Lee KJ, Cardella CJ, Benson LN, Rebeyka IM, Coles JG. ABO-incompatible heart transplantation in infants. N Engl J Med. 2001;15:793–800.

    Article  Google Scholar 

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Authors and Affiliations

  1. Departments of Cardiothoracic Surgery, Great Ormond Street Hospital for Sick Children, London, UK

    Nagarajan Muthialu & Tain-Yen Hsia

  2. Departments of Cardiology, Great Ormond Street Hospital for Sick Children, London, UK

    Michael Burch

Authors
  1. Nagarajan Muthialu
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  2. Michael Burch
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  3. Tain-Yen Hsia
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Corresponding author

Correspondence to Nagarajan Muthialu .

Editor information

Editors and Affiliations

  1. Our Lady’s Children's Hospital, National Children’s Research Centre, Dublin, Ireland

    Prem Puri

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Muthialu, N., Burch, M., Hsia, TY. (2020). Heart Transplantation. In: Puri, P. (eds) Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38482-0_119-1

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  • DOI: https://doi.org/10.1007/978-3-642-38482-0_119-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38482-0

  • Online ISBN: 978-3-642-38482-0

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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