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Hodgkin and Non-Hodgkin Lymphoma

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Abstract

Multimodal treatment strategies, using chemotherapy combined with radiotherapy within clinical multicenter trials, have improved survival of children and adolescents with lymphoma. The role of surgery in the treatment of children with lymphomas is limited to diagnostic biopsies and to tumor- or treatment-related complications.

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References

  • Akbayram S, Dogan M, Akgün C, et al. Use of rituximab in three children with relapsed/refractory Burkitt lymphoma. Target Oncol. 2010;5(4):291–4.

    Article  Google Scholar 

  • Appel BE, Chen L, Buxton A, et al. Impact of low-dose involved-field radiation therapy on pediatric patients with lymphocyte-predominant Hodgkin lymphoma treated with chemotherapy: a report from the Children’s Oncology Group. Pediatr Blood Cancer. 2012;59(7):1284–9.

    Article  Google Scholar 

  • Bonadonna G, Zucali R, Monfardini S, et al. Combination chemotherapy of Hodgkin’s disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide versus MOPP. Cancer. 1975;36:252–9.

    Article  CAS  Google Scholar 

  • Burkhardt B, Zimmermann M, Oschlies I, et al. The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence. Br J Haematol. 2005;131:39–49.

    Article  Google Scholar 

  • Burkhardt B, Oschlies I, Klapper W, et al. Non-Hodgkin’s lymphoma in adolescents: experiences in 378 adolescent NHL patients treated according to pediatric NHL-BFM protocols. Leukemia. 2011;25:153–60.

    Article  CAS  Google Scholar 

  • Carbone PP, Kaplan HS, Musshoff K, et al. Report of the committee on Hodgkin’s disease staging classification. Cancer Res. 1971;31:1860–1.

    CAS  PubMed  Google Scholar 

  • Castellino SM, Geiger AM, Mertens AC, et al. Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study. Blood. 2011;117(6):1806–16.

    Article  CAS  Google Scholar 

  • Chu Y, Gardenswartz A, Termuhlen AM, et al. Advances in cellular and humoral immunotherapy - implications for the treatment of poor risk childhood, adolescent, and young adult B-cell non-Hodgkin lymphoma. Br J Haematol. 2019;185(6):1055–70.

    Article  Google Scholar 

  • Devita VT Jr, Serpick AA, Carbone PP. Combination chemotherapy in the treatment of advanced Hodgkin’s disease. Ann Intern Med 1970; 73:881–895.

    Google Scholar 

  • Dörffel W, Lüders H, Rühl E, et al. Preliminary results of the multicenter trial GPOH-HD 95 for the treatment of Hodgkin’s disease in children and adolescents: analysis and outlook. Klin Pädiatr. 2003;215:139–45.

    Article  Google Scholar 

  • Dörffel W, Rühl U, Lüders H, et al. Treatment of children and adolescents with Hodgkin lymphoma without radiotherapy for patients in complete remission after chemotherapy: final results of the multinational trial GPOH-HD95. J Clin Oncol. 2013;31(12):1562–8.

    Article  Google Scholar 

  • Galper SL, Yu JB, Mauch PM, et al. Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation. Blood. 2011;117(2):412–8.

    Article  CAS  Google Scholar 

  • Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84:1361–92.

    Article  CAS  Google Scholar 

  • Jaffe ES, Harris NL, Stein H, Vardiman JW. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2001.

    Google Scholar 

  • Jerusalem G, Beguin Y, Fassotte MF, et al. Whole-body positron emission tomography using 18F- fluorodeoxyglucose for posttreatment evaluation in Hodgkin’s disease and non- Hodgkin’s lymphoma has higher diagnostic and prognostic value than classical computed tomography scan imaging. Blood. 1999;94:429–33.

    Article  CAS  Google Scholar 

  • Kluge R, Kurch L, Montravers F, et al. FDG PET/CT in children and adolescents with lymphoma. Pediatr Radiol. 2013;43:406–17.

    Article  Google Scholar 

  • Magrath IT. Lymphocyte differentiation: an essential basis for the comprehension of lymphoid neoplasia. J Natl Cancer Inst. 1981;67:501–14.

    CAS  PubMed  Google Scholar 

  • Mann G, Attarbaschi A, Steiner M, et al. Early and reliable diagnosis of non-Hodgkin lymphoma in childhood and adolescence: contribution of cytomorphology an flow cytometric immunophenotyping. Pediatr Hematol Oncol. 2006;23:167–76.

    Article  Google Scholar 

  • Michot JM, Lazarovici J, Ghez D, et al. Challenges and perspectives in the immunotherapy of Hodgkin lymphoma. Eur J Cancer. 2017;85:67–77.

    Article  CAS  Google Scholar 

  • Murphy SB. Classification, staging and end results of treatment of childhood non Hodgkin’s lymphomas: dissimilarities from lymphomas in adults. Semin Oncol. 1980;7:332–9.

    CAS  PubMed  Google Scholar 

  • Neth O, Seidemann K, Jansen P, et al. Precursor B-cell lymphoblastic lymphoma in childhood and adolescence: clinical features, treatment, and results in trials NHL 86 and 90. Med Pediatr Oncol. 2000;35:20–7.

    Article  CAS  Google Scholar 

  • Omer B, Kadan-Lottick NS, Roberts KB, et al. Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults. Br J Haematol. 2012;158(5):615–25.

    Article  Google Scholar 

  • Patte C, Auperin A, Michon J, et al. The Societe Francaise d’Oncologie Pediatrique LMB 89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia. Blood. 2001;97:3370–9.

    Article  CAS  Google Scholar 

  • Reiter A, Schrappe M, Tiemann M, et al. Improved treatment results in childhood B-cell neoplasm with tailored intensification of therapy: a report of the Berlin-Frankfurt-Münster group trial NHL-BFM 90. Blood. 1999;94:3294–306.

    CAS  PubMed  Google Scholar 

  • Reiter A, Schrappe M, Ludwig W-D, et al. Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: a BFM group report. Blood. 2000;95:416–21.

    CAS  PubMed  Google Scholar 

  • Sandlund JT, Downing JR, Crist WM. Non-Hodgkin’s lymphoma in childhood. N Engl J Med. 1996;334:1238–48.

    Article  CAS  Google Scholar 

  • Schmidt E, Burkhardt B. Lymphoblastic lymphoma in childhood and adolescence. Pediatr Hematol Oncol. 2013;30(6):484–508.

    Google Scholar 

  • Seidemann K, Tiemann M, Schrappe M, et al. Short-pulse B – non – Hodgkin lymphoma-type chemotherapy is efficacious treatment for pediatric anaplastic large cell lymphoma: a report of the Berlin-Frankfurt-Münster group trial NHL-BFM 90. Blood. 2001;97:3699–706.

    Article  CAS  Google Scholar 

  • Seidemann K, Tiemann M, Lauterbach I, et al. Primary mediastinal large B- cell lymphoma with sclerosis in pediatric and adolescent patients: treatment and results from three therapeutic studies of the Berlin-Frankfurt-Münster Group. J Clin Oncol. 2003;21:1782–9.

    Article  CAS  Google Scholar 

  • Song Y, Gao Q, Zhang H, et al. Treatment of relapsed or refractory classical Hodgkin lymphoma with the anti-PD-1, tislelizumab: results of a phase 2, single-arm, multicenter study. Leukemia. 2019; https://doi.org/10.1038/s41375-019-0545-2.

  • Van der Kaaij MAE, Van Echten-Arends J, Simons AHM, et al. Fertility preservation after chemotherapy for Hodgkin lymphoma. Hematol Oncol. 2010;28:168–79.

    Article  Google Scholar 

  • Wieland A, Kerbl R, Berghold A, et al. C-reactive protein (CRP) as tumor marker in pediatric and adolescent patients with Hodgkin disease. Med Pediatr Oncol. 2003;41:21–5.

    Article  Google Scholar 

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Authors and Affiliations

  1. Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria

    Christian Urban & Herwig Lackner

Authors
  1. Christian Urban
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  2. Herwig Lackner
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Corresponding author

Correspondence to Christian Urban .

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Editors and Affiliations

  1. Our Lady’s Children's Hospital, National Children’s Research Centre, Dublin, Ireland

    Prem Puri

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Urban, C., Lackner, H. (2020). Hodgkin and Non-Hodgkin Lymphoma. In: Puri, P. (eds) Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38482-0_152-1

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  • DOI: https://doi.org/10.1007/978-3-642-38482-0_152-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38482-0

  • Online ISBN: 978-3-642-38482-0

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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