Abstract
Antenatal hydronephrosis (AHN), also called urinary tract dilation, has been increasingly recognized with the widespread use of fetal ultrasound. Pediatricians, neonatologists, pediatric surgeons, and/or pediatric urologists are often faced with newborns and/or infants with asymptomatic hydronephrosis (HN) detected in utero and are expected to make management decisions regarding their ultrasonographic findings. In most instances, mild to moderate HN carries no clinical relevance as it resolves spontaneously after birth. However, there is a group of infants with urinary tract dilation who merit investigation and should be managed accordingly in order to avoid complications such as urinary tract infections and/or loss of renal function.
In this chapter, we will discuss the main urological malformations associated with AHN, as well as their postnatal evaluation and management.
Abbreviations
- AHN:
-
Antenatal hydronephrosis
- AP:
-
Antibiotic prophylaxis
- APD:
-
Anteroposterior diameter
- DMSA:
-
TcDimercaptosuccinic acid
- fUTI:
-
Febrile urinary tract infection
- GA:
-
Gestational age
- HN:
-
Hydronephrosis
- MAG3:
-
TcMercaptoacetyltriglycine
- MCDK:
-
Multicystic dysplastic kidney
- MRU:
-
Magnetic resonance urography
- SFU:
-
Society for fetal urology
- UPJO-like:
-
Ureteropelvic junction obstruction-like
- UTD:
-
Urinary tract dilation
- UTI:
-
Urinary tract infection
- VCUG:
-
Voiding cystourethrogram
- VUR :
-
Vesicoureteral reflux
References
Andrioli V, Guerra L, Keays M, et al. Active surveillance for antenatally detected ureteroceles: predictors of success. J Pediatr Urol. 2018;14(3):243.e1–6.
Braga LH, Mijovic H, Farrokhyar F, et al. Antibiotic prophylaxis for urinary tract infections in antenatal hydronephrosis. Pediatrics. 2013;131(1):e251–61.
Braga LH, Farrokhyar F, D’Cruz J, Pemberton J, Lorenzo AJ. Risk factors for febrile urinary tract infection in children with prenatal hydronephrosis: a prospective study. J Urol. 2015;193(5):1766–71.
Braga LH, D’Cruz J, Rickard M, et al. The fate of primary nonrefluxing megaureter: a prospective outcome analysis of the rate of urinary tract infections, surgical indications and time to resolution. J Urol. 2016;195(4 Pt 2):1300–5.
Braga LH, McGrath M, Farrokhyar F, et al. Associations of Initial Society for Fetal Urology Grades and Urinary Tract Dilatation Risk Groups with clinical outcomes in patients with isolated prenatal hydronephrosis. J Urol. 2017;197(3 Pt 2):831–7.
Braga LH, McGrath M, Farrokhyar F, et al. Society for Fetal Urology Classification vs urinary tract dilation grading system for prognostication in prenatal hydronephrosis: a time to resolution analysis. J Urol. 2018;199(6):1615–21.
Calaway AC, Whittam B, Szymanski KM, et al. Multicystic dysplastic kidney: is an initial voiding cystourethrogram necessary? Can J Urol. 2014;21(5):7510–4.
Capolicchio JP, Braga LH, Szymanski KM. Canadian Urological Association/Pediatric Urologists of Canada guideline on the investigation and management of antenatally detected hydronephrosis. Can Urol Assoc J. 2018;12(2):18–28.
Chamberlin JD, Braga LH, Davis-Dao CA, et al. Continuous antibiotic prophylaxis in isolated prenatal hydronephrosis. J Pediatr Urol. 2022;18(3):363.e1–7.
Clayton DB, Brock JW. Current state of fetal intervention for lower urinary tract obstruction. Curr Urol Rep. 2018;19(1):12.
Coelho GM, Bouzada MC, Lemos GS, et al. Risk factors for urinary tract infection in children with prenatal renal pelvic dilatation. J Urol. 2008;179(1):284–9.
Conway JJ, Maizels M. The well tempere diuretic renogram: a standard method to examine the asymptomatic neonate with hydronephrosis or hydroureteronephrosis. A report from combined meetings of The Society for Fetal Urology and members of The Pediatric Nuclear Medicine Council – The Society of Nuclear Medicine. J Nucl Med. 1992;33(11):2047–51.
Coplen DE, Austin PF, Yan Y, et al. The magnitude of fetal renal pelvic dilatation can identify obstructive postnatal hydronephrosis, and direct postnatal evaluation and management. J Urol. 2006;176(2):724–7; discussion 727
De Caluwe D, Chertin B, Puri P. Fate of the retained ureteral stump after upper pole heminephrectomy in duplex kidneys. J Urol. 2002;168(2):679–80.
Dhillon HK. Prenatally diagnosed hydronephrosis: the Great Ormond Street experience. Br J Urol. 1998;81(Suppl 2):39–44.
Easterbrook B, Capolicchio JP, Braga LH. Antibiotic prophylaxis for prevention of urinary tract infections in prenatal hydronephrosis: an updated systematic review. Can Urol Assoc J. 2017;11(1–2Suppl1):S3–S11.
Echeverria P, Reed LF, Gatti JM, et al. Latitudes and attitudes: a multinational study of laparoscopic pyeloplasty in children. J Ped Urol. 2023;19(1):86.e186.e6.
Farrugia M-K. Fetal bladder outlet obstruction: embryopathology, in utero intervention and outcome. J Pediatr Urol. 2016;12(5):296–303.
Farrugia M-K, Hitchcock R, Radford A, et al. British Association of Paediatric Urologists consensus statement on the management of the primary obstructive megaureter. J Pediatr Urol. 2014;10(1):26–33.
Fernbach SK, Maizels M, Conway JJ. Ultrasound grading of hydronephrosis: introduction to the system used by the Society for Fetal Urology. Pediatr Radiol. 1993;23(6):478–80.
Frimberger D, Mercado-Deane MG, SECTION ON UROLOGY, SECTION ON RADIOLOGY. Establishing a standard protocol for the voiding cystourethrography. Pediatrics. 2016;138(5):e20162590.
Herndon CDA, McKenna PH, Kolon TF, et al. A multicenter outcomes analysis of patients with neonatal reflux presenting with prenatal hydronephrosis. J Urol. 1999;162(3 II):1203.
Holzman SA, Braga LH, Zee RS, et al. Risk of urinary tract infection in patients with hydroureter: an analysis from the Society of Fetal Urology Prenatal Hydronephrosis Registry. J Pediatr Urol. 2021;17(6):775–81.
Husmann DA, Ewalt DH, Glenski WJ, Bernier PA. Ureterocele associated with ureteral duplication and a nonfunctioning upper pole segment: management by partial nephroureterectomy alone. J Urol. 1995;154(2 Pt 2):723–6.
Jackson JN, Zee RS, Martin AN, Corbett ST, Herndon CDA. A practice pattern assessment of members of the Society of Pediatric Urology for evaluation and treatment of urinary tract dilation. J Pediatr Urol. 2017;13(6):602–7.
Jesus LE, Farhat WA, Amarante AC, et al. Clinical evolution of vesicoureteral reflux following endoscopic puncture in children with duplex system ureteroceles. J Urol. 2011;186(4):1455–8.
Lee RS, Cendron M, Kinnamon DD, et al. Antenatal hydronephrosis as a predictor of postnatal outcome: a meta-analysis. Pediatrics. 2006;118(2):586–93.
Lee JH, Choi HS, Kim JK, et al. Nonrefluxing neonatal hydronephrosis and the risk of urinary tract infection. J Urol. 2008;179(4):1524–8.
Liu DB, Palmer B, Herndon CD, et al. Teaching of the Society for Fetal Urology grading system for pediatric hydronephrosis is improved by e-Learning using Computer Enhanced Visual Learning (CEVL): a multi-institutional trial. J Pediatr Urol. 2015;11(4):184.e1–8.
McLellan DL, Retik AB, Bauer SB, et al. Rate and predictors of spontaneous resolution of prenatally diagnosed primary nonrefluxing megaureter. J Urol. 2002;168(5):2177–80. discussion 2180
McLorie G, Farhat W, Khoury A, et al. Outcome analysis of vesicoamniotic shunting in a comprehensive population. J Urol. 2001;166(3):1036–40.
Morris RK, Quinlan-Jones E, Kilby MD, et al. Systematic review of accuracy of fetal urine analysis to predict poor postnatal renal function in cases of congenital urinary tract obstruction. Prenat Diagn. 2007;27(10):900–11.
Morris RK, Malin GL, Quinlan-Jones E, et al. Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial. Lancet. 2013;382(9903):1496–506.
Narchi H. Risk of Wilms’ tumour with multicystic kidney disease: a systematic review. Arch Dis Child. 2005;90(2):147–9.
Nguyen HT, Herndon CDA, Cooper C, et al. The Society for Fetal Urology consensus statement on the evaluation and management of antenatal hydronephrosis. J Pediatr Urol. 2010;6(3):212–31.
Nguyen HT, Benson CB, Bromley B, et al. Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system). J Pediatr Urol. 2014;10(6):992–8.
Peters CA, Carr MC, Lais A, et al. The response of the fetal kidney to obstruction. J Urol. 1992;148(2 Pt 2):503–9.
Rickard M, Easterbrook B, Kim S, et al. Six of one, half a dozen of the other: a measure of multidisciplinary inter/intra-rater reliability of the society for fetal urology and urinary tract dilation grading systems for hydronephrosis. J Pediatr Urol. 2017;13(1):80.e1–5.
Ross SS, Kardos S, Krill A, et al. Observation of infants with SFU grades 3–4 hydronephrosis: worsening drainage with serial diuresis renography indicates surgical intervention and helps prevent loss of renal function. J Pediatr Urol. 2011;7(3):266–71.
Ruano R, Sananes N. Sangi-Haghpeykar et al. Fetal intervention for severe lower urinary tract obstruction: a multicenter case-control study comparing fetal cystoscopy with vesicoamniotic shunting. Ultrasound Obstet Gynecol. 2015;45(4):452–8.
Ruano R, Sananes N, Wilson C, et al. Fetal lower urinary tract obstruction: proposal for standardized multidisciplinary prenatal management based on disease severity. Ultrasound Obstet Gynecol. 2016;48(4):476–82.
Shamshirsaz AA, Ravangard SF, Egan JF, et al. Fetal hydronephrosis as a predictor of neonatal urologic outcomes. Ultrasound Med. 2012;31(6):947–54.
Song SH, Lee SB, Park YS, Kim KS. Is antibiotic prophylaxis necessary in infants with obstructive hydronephrosis? J Urol. 2007;177(3):1098–101. discussion 1101
Zanetta VC, Rosman BM, Bromley B, et al. Variations in management of mild prenatal hydronephrosis among maternal-fetal medicine obstetricians, and pediatric urologists and radiologists. J Urol. 2012;188(5):1935–9.
Zee RS, Herbst KW, Kim C, et al. Urinary tract infections in children with prenatal hydronephrosis: a risk assessment from the Society for Fetal Urology Hydronephrosis Registry. J Pediatr Urol. 2016;12(4):261.e1–7.
Zee RS, Herndon CDA, Cooper CS, et al. Time to resolution: a prospective evaluation from the Society for Fetal Urology hydronephrosis registry. J Pediatr Urol. 2017;12(17):316.e1–316.e5.
Zhang L, Li Y, Liu C, et al. Diagnostic value of anteroposterior diameter of renal pelvis for predicting postnatal surgery: a systematic review and meta-analysis. J Urol. 2018;200(6):1346–53.
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Braga, L.H., Herndon, C.A. (2023). Antenatal Hydronephrosis. In: Puri, P. (eds) Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38482-0_164-1
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DOI: https://doi.org/10.1007/978-3-642-38482-0_164-1
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