Skip to main content

Renal Calculus Disease

  • Living reference work entry
  • First Online:
Pediatric Surgery

Abstract

Once considered a rare and benign disease, pediatric urolithiasis has recently shown an increased incidence. The sex distribution may also be different in children, with a female preponderance in the second decade of life. The characteristic feature of pediatric stone disease is the frequency of an underlying metabolic etiology, with 50% of children under 10 years of age with stone disease, having an underlying metabolic disorder. In this chapter, we will address the differences between stone disease in children and adults and recently observed trends/shifts in pediatric nephrolithiasis, as well as advances in pathophysiology and treatment strategies, and future directions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Assael BM, Castellani C, Ocampo MB, Iansa P, Callegaro A, Valsecchi MG. Epidemiology and survival analysis of cystic fibrosis in an area of intense neonatal screening over 30 years. Am J Epidemiol. 2002;156(5):397–401.

    Article  PubMed  Google Scholar 

  • Bagga HS, Chi T, Miller J, Stoller ML. New insights into the pathogenesis of renal calculi. Urol Clin North Am. 2013;40(1):1–12.

    Article  PubMed  Google Scholar 

  • Bergsland KJ, Coe FL, White MD, Erhard MJ, DeFoor WR, Mahan JD, Schwaderer AL, Asplin JR. Urine risk factors in children with calcium kidney stones and their siblings. Kidney Int. 2012;81(11):1140–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bowman RM, McLone DG, Grant JA, Tomita T, Ito JA. Spina bifida outcome: a 25-year prospective. Pediatr Neurosurg. 2001;34(3):114–20.

    Article  CAS  PubMed  Google Scholar 

  • Bush NC, Xu L, Brown BJ, Holzer MS, Gingrich A, Schuler B, Tong L, Baker LA. Hospitalizations for pediatric stone disease in United States, 2002–2007. J Urol. 2010;183:1151–6.

    Article  PubMed  Google Scholar 

  • Cameron MA, Sakhaee K, Moe OW. Nephrolithiasis in children. Pediatr Nephrol. 2005;20(11):1587–92.

    Article  PubMed  Google Scholar 

  • Copelovitch L. Urolithiasis in children: medical approach. Pediatr Clin N Am. 2012;59(4):881–96.

    Article  Google Scholar 

  • D'Addessi A, Bongiovanni L, Sasso F, Gulino G, Falabella R, Bassi P. Extracorporeal shockwave lithotripsy in pediatrics. J Endourol. 2008;22(1):1–12.

    Article  PubMed  Google Scholar 

  • Dogan HS, Tekgul S. Management of pediatric stone disease. Curr Urol Rep. 2007;8(2):163–73.

    Article  PubMed  Google Scholar 

  • Dursun I, Poyrazoglu HM, Dusunsel R, Gunduz Z, Gurgoze MK, Demirci D, Kucukaydin M. Pedriatric urolithiasis: an 8-year experience of single centre. Int Urol Nephrol. 2008;40(1):3–9.

    Article  PubMed  Google Scholar 

  • Edvardsson V, Elidottir H, Indridasson OS, Palsson R. High incidence of kidney stones in Icelandic children. Pediatr Nephrol. 2005;20(7):940–4.

    PubMed  Google Scholar 

  • Evan AP, Lingeman JE, Coe FL, Parks JH, Bledsoe SB, Shao Y, Sommer AJ, Paterson RF, Kuo RL, Grynpas M. Randall’s plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. J Clin Invest. 2003;111(5):607–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Finlayson B, Reid F. The expectation of free and fixed particles in urinary stone disease. Investig Urol. 1978;15(6):442–8.

    CAS  Google Scholar 

  • Ghani KR, Trinh QD, Jeong W, Friedman A, Lakshmanan Y, Menon M, Elder JS. Robotic nephrolithotomy and pyelolithotomy with utilization of the robotic ultrasound probe. Int Braz J Urol. 2014;40(1):125–6.

    Article  PubMed  Google Scholar 

  • Gurgoze MK, Sari MY. Results of medical treatment and metabolic risk factors in children with urolithiasis. Pediatr Nephrol. 2011;26(6):933–7.

    Article  PubMed  Google Scholar 

  • Karunakaran P, Pathak A, Shandilya G, Puneeth Kumar KM, Anand M, Yadav P, Srivastava A, Ansari MS. Safety and efficacy of retrograde intrarenal surgery in primary and residual renalcalculi in children. J Pediatr Urol. 2022;18(3):312.e1–5.

    Article  Google Scholar 

  • Kok DJ, Khan SR. Calcium oxalate nephrolithiasis, a free or fixed particle disease. Kidney Int. 1994;46(3):847–54.

    Article  CAS  PubMed  Google Scholar 

  • Kovacevic L, Wolfe-Christensen C, Edwards L, Sadaps M, Lakshmanan Y. From hypercalciuria to hypocitraturia - An evolving trend in pediatric urolithiasis? J Urol. 2012;188(4 suppl):1623–7.

    Article  CAS  PubMed  Google Scholar 

  • Kovacevic L, Lu H, Caruso JA, Kovacevic N, Lakshmanan Y. Urinary proteomics reveals association between pediatric nephrolithiasis and cardiovascular disease. Int Urol Nephrol. 2018;50(11):1949–54.

    Article  CAS  PubMed  Google Scholar 

  • Kovacevic L, Caruso JA, Lu H, Kovacevic N, Lakshmanan Y, Carruthers NJ, Goldfarb DS. Urine proteomic profiling in patients with nephrolithiasis and cystinuria. Int Urol Nephrol. 2019;51(4):593–9.

    Article  CAS  PubMed  Google Scholar 

  • Kwon MS, Lim SW, Kwon HM. Hypertonic stress in the kidney: a necessary evil. Physiology (Bethesda). 2009;24:186–91.

    CAS  Google Scholar 

  • McKay CP. Renal stone disease. Pediatr Rev. 2010;31(5):179–88.

    Article  PubMed  Google Scholar 

  • Milliner DS. Calcium oxalate in biological systems: Epidemiology of calcium oxalate urolithiasis in man. Boca Raton: CRC Press; 1995.

    Google Scholar 

  • Milliner DS, Murphy MF. Urolithiasis in pediatric patients. Mayo Clin Proc. 1993;68(3):241–8.

    Article  CAS  PubMed  Google Scholar 

  • Miyake O, Kakimoto K, Tsujihata M, Yoshimura K, Takahara S, Okuyama A. Strong inhibition of crystal-cell attachment by pediatric urinary macromolecules: a close relationship with high urinary citrate secretion. Urology. 2001;58(3):493–7.

    Article  CAS  PubMed  Google Scholar 

  • Novak TE, Lakshmanan Y, Trock BJ, Gearhart JP, Matlaga BR. Sex Prevalence of pediatric kidney stone disease in the United States: an epidemiologic investigation. Urology. 2009;74(1):104–7.

    Article  PubMed  Google Scholar 

  • O’Connor PM. Renal oxygen delivery: matching delivery to metabolic demand. Clin Exp Pharmacol Physiol. 2006;33(10):961–7.

    Article  PubMed  Google Scholar 

  • Perrone HC, dos Santos DR, Santos MV, Pinheiro ME, Toporovski J, Ramos OL, Schor N. Urolithiasis in childhood: metabolic evaluation. Pediatr Nephrol. 1992;6(1):54–6.

    Article  CAS  PubMed  Google Scholar 

  • Pickard R, Starr K, MacLennan G, Lam T, Thomas R, Burr J, McPherson G, McDonald A, Anson K, N'Dow J, Burgess N, Clark T, Kilonzo M, Gillies K, Shearer K, Boachie C, Cameron S, Norrie J, McClinton S. Medical expulsive therapy in adults with ureteric colic: a multicentre, randomized, placebo-controlled trial. Lancet. 2015;386(9991):341–9.

    Article  PubMed  Google Scholar 

  • Pietrow PK, Pope JC IV, Adams MC, Shyr Y, Brock JW 3rd. Clinical outcome of pediatric stone disease. J Urol. 2002;167(2 Pt 1):670–3.

    Article  PubMed  Google Scholar 

  • Randall A. The origin and growth of renal calculi. Ann Surg. 1937;105(6):1009–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Routh JC, Graham DA, Nelson CP. Epidemiological trends in pediatric urolithiasis at United States freestanding pediatric hospitals. J Urol. 2010;184(3):1100–4.

    Article  PubMed  Google Scholar 

  • Sarkissian A, Babloyan A, Arikyants N, Hesse A, Blau N, Leumann E. Pediatric urolithiasis in Armenia: a study of 198 patients observed from 1991 to 1999. Pediatr Nephrol. 2001;16(9):728–32.

    Article  CAS  PubMed  Google Scholar 

  • Sas DJ. An update on the changing epidemiology and metabolic risk factors in pediatric kidney stone disease. Clin J Am Soc Nephrol. 2011;6(8):2062–8.

    Article  PubMed  Google Scholar 

  • Sas DJ. Dietary risk factors for urinary stones in children. Curr Opin Pediatr. 2020;32(2):284–7.

    Article  PubMed  Google Scholar 

  • Sas DJ, Hulsey TC, Shatat IF, Orak JK. Increasing incidence of kidney stones in children evaluated in the emergency department. J Pediatr. 2010;157(1):132–7.

    Article  PubMed  Google Scholar 

  • Schissel BL, Johnson BK. Renal stones: evolving epidemiology and management. Pediatr Emerg Care. 2011;27(7):676–81.

    Article  PubMed  Google Scholar 

  • Schlomer BJ. Urologic treatment of nephrolithiasis. Curr Opin Pediatr. 2020;32(2):288–94.

    Article  PubMed  Google Scholar 

  • Seitz C, Liatsikos E, Porpiglia F, Tiselius HG, Zwergel U. Medical therapy to facilitate the passage of stones: what is the evidence? Eur Urol. 2009;56(3):455–71.

    Article  PubMed  Google Scholar 

  • Shekarriz B, Lu HF, Stoller ML. Correlation of unilateral urolithiasis with sleep posture. J Urol. 2001;165:1085–7.

    Article  CAS  PubMed  Google Scholar 

  • Singh P, Harris PC, Sas DJ, Lieske JC. The genetics of kidney stone disease and nephrocalcinosis. Nat Rev Nephrol. 2022 Apr;18(4):224–40.

    Article  PubMed  Google Scholar 

  • Smaldone MC, Docimo SG, Ost MC. Contemporary surgical management of pediatric urolithiasis. Urol Clin North Am. 2010;37(2):253–67.

    Article  PubMed  Google Scholar 

  • Smith SL, Somers JM, Broderick N, Halliday K. The role of the plain radiograph and renal tract ultrasound in the management of children with renal tract calculi. Clin Radiol. 2000;55(99):708–10.

    Article  CAS  PubMed  Google Scholar 

  • Spivacow FR, Del Valle EE, Boailchuk JA, Sandoval Díaz G, Rodríguez Ugarte V, Arreaga ÁZ. Metabolic risk factors in children with kidney stone disease: an update. Pediatr Nephrol. 2020 Nov;35(11):2107–12.

    Article  PubMed  Google Scholar 

  • Stapleton FB. Clinical approach to children with urolithiasis. Semin Nephrol. 1996;16(5):389–97.

    CAS  PubMed  Google Scholar 

  • Tasian GE, Copelovitch L. Evaluation and medical management of kidney stones in children. J Urol. 2014;192(5):1329–36.

    Article  PubMed  Google Scholar 

  • Velázquez N, Zapata D, Wang HH, Wiener JS, Lipkin ME, Routh JC. Medical expulsive therapy for pediatric urolithiasis: systematic review and meta-analysis. J Pediatr Urol. 2015;11(6):321–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vrtiska TJ, Hattery RR, King BF, Charboneau JW, Smith LH, Williamson B Jr, Brakke DM. Role of ultrasound in medical management of patients with renal stone disease. Urol Radiol. 1992;14(3):131–8.

    Article  CAS  PubMed  Google Scholar 

  • Yasui T, Iguchi M, Suzuki S, Kohri K. Prevalence and epidemiological characteristics of urolithiasis in Japan: National trends between 1965 and 2005. Urology. 2008;71(2):209–13.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yegappan Lakshmanan .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer-Verlag GmbH Germany, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Kovacevic, L.G., Lakshmanan, Y. (2022). Renal Calculus Disease. In: Puri, P. (eds) Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38482-0_174-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-38482-0_174-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38482-0

  • Online ISBN: 978-3-642-38482-0

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics