Abstract
Once considered a rare and benign disease, pediatric urolithiasis has recently shown an increased incidence. The sex distribution may also be different in children, with a female preponderance in the second decade of life. The characteristic feature of pediatric stone disease is the frequency of an underlying metabolic etiology, with 50% of children under 10 years of age with stone disease, having an underlying metabolic disorder. In this chapter, we will address the differences between stone disease in children and adults and recently observed trends/shifts in pediatric nephrolithiasis, as well as advances in pathophysiology and treatment strategies, and future directions.
References
Assael BM, Castellani C, Ocampo MB, Iansa P, Callegaro A, Valsecchi MG. Epidemiology and survival analysis of cystic fibrosis in an area of intense neonatal screening over 30 years. Am J Epidemiol. 2002;156(5):397–401.
Bagga HS, Chi T, Miller J, Stoller ML. New insights into the pathogenesis of renal calculi. Urol Clin North Am. 2013;40(1):1–12.
Bergsland KJ, Coe FL, White MD, Erhard MJ, DeFoor WR, Mahan JD, Schwaderer AL, Asplin JR. Urine risk factors in children with calcium kidney stones and their siblings. Kidney Int. 2012;81(11):1140–8.
Bowman RM, McLone DG, Grant JA, Tomita T, Ito JA. Spina bifida outcome: a 25-year prospective. Pediatr Neurosurg. 2001;34(3):114–20.
Bush NC, Xu L, Brown BJ, Holzer MS, Gingrich A, Schuler B, Tong L, Baker LA. Hospitalizations for pediatric stone disease in United States, 2002–2007. J Urol. 2010;183:1151–6.
Cameron MA, Sakhaee K, Moe OW. Nephrolithiasis in children. Pediatr Nephrol. 2005;20(11):1587–92.
Copelovitch L. Urolithiasis in children: medical approach. Pediatr Clin N Am. 2012;59(4):881–96.
D'Addessi A, Bongiovanni L, Sasso F, Gulino G, Falabella R, Bassi P. Extracorporeal shockwave lithotripsy in pediatrics. J Endourol. 2008;22(1):1–12.
Dogan HS, Tekgul S. Management of pediatric stone disease. Curr Urol Rep. 2007;8(2):163–73.
Dursun I, Poyrazoglu HM, Dusunsel R, Gunduz Z, Gurgoze MK, Demirci D, Kucukaydin M. Pedriatric urolithiasis: an 8-year experience of single centre. Int Urol Nephrol. 2008;40(1):3–9.
Edvardsson V, Elidottir H, Indridasson OS, Palsson R. High incidence of kidney stones in Icelandic children. Pediatr Nephrol. 2005;20(7):940–4.
Evan AP, Lingeman JE, Coe FL, Parks JH, Bledsoe SB, Shao Y, Sommer AJ, Paterson RF, Kuo RL, Grynpas M. Randall’s plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. J Clin Invest. 2003;111(5):607–16.
Finlayson B, Reid F. The expectation of free and fixed particles in urinary stone disease. Investig Urol. 1978;15(6):442–8.
Ghani KR, Trinh QD, Jeong W, Friedman A, Lakshmanan Y, Menon M, Elder JS. Robotic nephrolithotomy and pyelolithotomy with utilization of the robotic ultrasound probe. Int Braz J Urol. 2014;40(1):125–6.
Gurgoze MK, Sari MY. Results of medical treatment and metabolic risk factors in children with urolithiasis. Pediatr Nephrol. 2011;26(6):933–7.
Karunakaran P, Pathak A, Shandilya G, Puneeth Kumar KM, Anand M, Yadav P, Srivastava A, Ansari MS. Safety and efficacy of retrograde intrarenal surgery in primary and residual renalcalculi in children. J Pediatr Urol. 2022;18(3):312.e1–5.
Kok DJ, Khan SR. Calcium oxalate nephrolithiasis, a free or fixed particle disease. Kidney Int. 1994;46(3):847–54.
Kovacevic L, Wolfe-Christensen C, Edwards L, Sadaps M, Lakshmanan Y. From hypercalciuria to hypocitraturia - An evolving trend in pediatric urolithiasis? J Urol. 2012;188(4 suppl):1623–7.
Kovacevic L, Lu H, Caruso JA, Kovacevic N, Lakshmanan Y. Urinary proteomics reveals association between pediatric nephrolithiasis and cardiovascular disease. Int Urol Nephrol. 2018;50(11):1949–54.
Kovacevic L, Caruso JA, Lu H, Kovacevic N, Lakshmanan Y, Carruthers NJ, Goldfarb DS. Urine proteomic profiling in patients with nephrolithiasis and cystinuria. Int Urol Nephrol. 2019;51(4):593–9.
Kwon MS, Lim SW, Kwon HM. Hypertonic stress in the kidney: a necessary evil. Physiology (Bethesda). 2009;24:186–91.
McKay CP. Renal stone disease. Pediatr Rev. 2010;31(5):179–88.
Milliner DS. Calcium oxalate in biological systems: Epidemiology of calcium oxalate urolithiasis in man. Boca Raton: CRC Press; 1995.
Milliner DS, Murphy MF. Urolithiasis in pediatric patients. Mayo Clin Proc. 1993;68(3):241–8.
Miyake O, Kakimoto K, Tsujihata M, Yoshimura K, Takahara S, Okuyama A. Strong inhibition of crystal-cell attachment by pediatric urinary macromolecules: a close relationship with high urinary citrate secretion. Urology. 2001;58(3):493–7.
Novak TE, Lakshmanan Y, Trock BJ, Gearhart JP, Matlaga BR. Sex Prevalence of pediatric kidney stone disease in the United States: an epidemiologic investigation. Urology. 2009;74(1):104–7.
O’Connor PM. Renal oxygen delivery: matching delivery to metabolic demand. Clin Exp Pharmacol Physiol. 2006;33(10):961–7.
Perrone HC, dos Santos DR, Santos MV, Pinheiro ME, Toporovski J, Ramos OL, Schor N. Urolithiasis in childhood: metabolic evaluation. Pediatr Nephrol. 1992;6(1):54–6.
Pickard R, Starr K, MacLennan G, Lam T, Thomas R, Burr J, McPherson G, McDonald A, Anson K, N'Dow J, Burgess N, Clark T, Kilonzo M, Gillies K, Shearer K, Boachie C, Cameron S, Norrie J, McClinton S. Medical expulsive therapy in adults with ureteric colic: a multicentre, randomized, placebo-controlled trial. Lancet. 2015;386(9991):341–9.
Pietrow PK, Pope JC IV, Adams MC, Shyr Y, Brock JW 3rd. Clinical outcome of pediatric stone disease. J Urol. 2002;167(2 Pt 1):670–3.
Randall A. The origin and growth of renal calculi. Ann Surg. 1937;105(6):1009–27.
Routh JC, Graham DA, Nelson CP. Epidemiological trends in pediatric urolithiasis at United States freestanding pediatric hospitals. J Urol. 2010;184(3):1100–4.
Sarkissian A, Babloyan A, Arikyants N, Hesse A, Blau N, Leumann E. Pediatric urolithiasis in Armenia: a study of 198 patients observed from 1991 to 1999. Pediatr Nephrol. 2001;16(9):728–32.
Sas DJ. An update on the changing epidemiology and metabolic risk factors in pediatric kidney stone disease. Clin J Am Soc Nephrol. 2011;6(8):2062–8.
Sas DJ. Dietary risk factors for urinary stones in children. Curr Opin Pediatr. 2020;32(2):284–7.
Sas DJ, Hulsey TC, Shatat IF, Orak JK. Increasing incidence of kidney stones in children evaluated in the emergency department. J Pediatr. 2010;157(1):132–7.
Schissel BL, Johnson BK. Renal stones: evolving epidemiology and management. Pediatr Emerg Care. 2011;27(7):676–81.
Schlomer BJ. Urologic treatment of nephrolithiasis. Curr Opin Pediatr. 2020;32(2):288–94.
Seitz C, Liatsikos E, Porpiglia F, Tiselius HG, Zwergel U. Medical therapy to facilitate the passage of stones: what is the evidence? Eur Urol. 2009;56(3):455–71.
Shekarriz B, Lu HF, Stoller ML. Correlation of unilateral urolithiasis with sleep posture. J Urol. 2001;165:1085–7.
Singh P, Harris PC, Sas DJ, Lieske JC. The genetics of kidney stone disease and nephrocalcinosis. Nat Rev Nephrol. 2022 Apr;18(4):224–40.
Smaldone MC, Docimo SG, Ost MC. Contemporary surgical management of pediatric urolithiasis. Urol Clin North Am. 2010;37(2):253–67.
Smith SL, Somers JM, Broderick N, Halliday K. The role of the plain radiograph and renal tract ultrasound in the management of children with renal tract calculi. Clin Radiol. 2000;55(99):708–10.
Spivacow FR, Del Valle EE, Boailchuk JA, Sandoval Díaz G, Rodríguez Ugarte V, Arreaga ÁZ. Metabolic risk factors in children with kidney stone disease: an update. Pediatr Nephrol. 2020 Nov;35(11):2107–12.
Stapleton FB. Clinical approach to children with urolithiasis. Semin Nephrol. 1996;16(5):389–97.
Tasian GE, Copelovitch L. Evaluation and medical management of kidney stones in children. J Urol. 2014;192(5):1329–36.
Velázquez N, Zapata D, Wang HH, Wiener JS, Lipkin ME, Routh JC. Medical expulsive therapy for pediatric urolithiasis: systematic review and meta-analysis. J Pediatr Urol. 2015;11(6):321–7.
Vrtiska TJ, Hattery RR, King BF, Charboneau JW, Smith LH, Williamson B Jr, Brakke DM. Role of ultrasound in medical management of patients with renal stone disease. Urol Radiol. 1992;14(3):131–8.
Yasui T, Iguchi M, Suzuki S, Kohri K. Prevalence and epidemiological characteristics of urolithiasis in Japan: National trends between 1965 and 2005. Urology. 2008;71(2):209–13.
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Kovacevic, L.G., Lakshmanan, Y. (2022). Renal Calculus Disease. In: Puri, P. (eds) Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38482-0_174-1
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DOI: https://doi.org/10.1007/978-3-642-38482-0_174-1
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