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Immunology and Immunodeficiencies in Children

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Abstract

The immune system in neonates is different to that of adults and evolves in the first few years of life to achieve adult-like responses. This chapter highlights the response of the immune system to sepsis both in pediatric and neonatal age groups and the intricate balance between pro-inflammatory and anti-inflammatory responses to limit the damage secondary to infections. Immunodeficiencies primary or acquired are described in detail including their common presentations, common pathogens involved, the cell type involved, mechanism of deficiency, treatment, and prognosis including specific considerations for these patients prior to surgery. Immunomodulation of immune system either by alteration in ligand receptor binding or intracellular signal can help to modulate the disease process and may alter the prognosis for children with sepsis in the future.

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Authors and Affiliations

  1. Discipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland

    Saima Aslam, Fiona O’Hare, Hassan Eliwan & Eleanor J. Molloy

  2. Tallaght Hospital & Coombe Women’s and Infants University Hospital, Dublin, Ireland

    Saima Aslam, Fiona O’Hare, Hassan Eliwan & Eleanor J. Molloy

Authors
  1. Saima Aslam
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  2. Fiona O’Hare
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  3. Hassan Eliwan
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  4. Eleanor J. Molloy
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Correspondence to Saima Aslam .

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Editors and Affiliations

  1. Our Lady’s Children's Hospital, National Children’s Research Centre, Dublin, Ireland

    Prem Puri

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Aslam, S., O’Hare, F., Eliwan, H., Molloy, E.J. (2019). Immunology and Immunodeficiencies in Children. In: Puri, P. (eds) Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38482-0_29-2

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  • DOI: https://doi.org/10.1007/978-3-642-38482-0_29-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38482-0

  • Online ISBN: 978-3-642-38482-0

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Chapter history

  1. Latest

    Immunology and Immunodeficiencies in Children
    Published:
    24 December 2018

    DOI: https://doi.org/10.1007/978-3-642-38482-0_29-2

  2. Original

    Immunology and Immunodeficiencies in Children
    Published:
    03 March 2017

    DOI: https://doi.org/10.1007/978-3-642-38482-0_29-1

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