Congenital Hyperinsulinism

  • Augusto ZaniEmail author
  • Agostino Pierro
Living reference work entry


Congenital hyperinsulinism (CHI) comprises a group of disorders characterized by excessive insulin secretion from pancreatic β-cells, resulting in severe hypoglycemia. In neonates and infants, CHI is considered the most frequent cause of persistent hypoglycemia. Prompt diagnosis and treatment are crucial as a delay may cause severe brain damage and long-term neurodevelopmental disability. Therapeutic strategies for CHI can be medical, surgical, or combined.


Congenital hyperinsulinism Transient hyperinsulinism Persistent hyperinsulinism Hypoglycemia Pancreatectomy 


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Division of General and Thoracic SurgeryThe Hospital for Sick Children, University of TorontoTorontoCanada

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