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Gastroesophageal Reflux and Hiatal Hernia

  • Michael E. HöllwarthEmail author
  • Erich Sorantin
Living reference work entry
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Abstract

Gastroesophageal reflux, caused by transient relaxation of the lower esophageal sphincter, is the term used to describe the backflow of gastric content into the esophagus. Pathological reflux disease is a situation in which reflux causes major symptoms and complications such as failure to thrive, disturbances of sleep, recurrent aspiration and cough predominantly in young infants and epigastric pain, esophagitis, stenosis, or Barrett’s esophagus in older children. A variety of diagnostic investigations are necessary to evaluate the extent and consequences of pathological reflux. Conservative management with different medications is widely used. However, in children with chronic gastroesophageal disease, surgical therapy by fundoplication is the treatment of choice.

Keywords

Gastroesophageal reflux Esophagitis Barrett’s esophagus Fundoplication Hiatus hernia Eosinophilic esophagitis Sandifer syndrome 

References

  1. Abrams JA, Kapel RC, Lindberg GM, et al. Adherence to biopsy guidelines for Barrett’s esophagus surveillance in the community setting in the United States. Clin Gastroenterol Hepatol. 2009;7:736–42.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Alterio T, Cardile S, Trayers C, et al. Eosinophilic esophagitis in children: current knowledge to open new horizons. Scand J Gastroenterol. 2019;54(7):822–9.PubMedCrossRefPubMedCentralGoogle Scholar
  3. Augood C, MacLennan S, Gilbert RE, et al. Cisapride treatment for gastro-oesophageal reflux in children. Cochrane Database Syst Rev. 2003;4:1–19.Google Scholar
  4. Bell RC, Cardiere GB. Transoral rotational esophagogastric fundoplication: technical, anatomical, and safety considerations. Surg Endosc. 2011;25:2387–99.PubMedCrossRefPubMedCentralGoogle Scholar
  5. Bennett C, Vakil N, Bergman J, et al. Consensus statements for management of Barrett’s dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process. Gastroenterology. 2012;143:336–46.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Berni Canani RB, Terrin G. Gastric acidity inhibitors and the risk of intestinal infections. Curr Opin Gastroenterol. 2010;26:31–5.CrossRefGoogle Scholar
  7. Bianchi A. Total esophagogastric dissociation: an alternative approach. J Pediatr Surg. 1997;32:1291–4.PubMedCrossRefPubMedCentralGoogle Scholar
  8. Binet A, Fourcade L, Amar S, et al. Robot-assisted laparoscopic fundoplications in pediatric surgery: experience review. Eur J Pediatr Surg. 2019;29(2):173–8.PubMedCrossRefPubMedCentralGoogle Scholar
  9. Blondeau K, Mertens V, Dupont L, et al. The relationship between gastroesophageal reflux and cough in children with chronic unexplained cough using combined impedance-pH-manometry recordings. Pediatr Pulmonol. 2011;46:286–94.PubMedCrossRefPubMedCentralGoogle Scholar
  10. Bulsiewicz WJ, Kim HP, Dellon ES, et al. Safety and efficacy of endoscopic mucosal therapy with radiofrequency ablation for patients with neoplastic Barrett’s esophagus. Clin Gastroenterol Hepatol. 2013;11:636–42.PubMedCrossRefPubMedCentralGoogle Scholar
  11. Butterfield DG, Struthers JE, Showalter BS. A test of gastroesophageal sphincter competence. The common cavity test. Am J Dig Dis. 1972;17:415–21.PubMedCrossRefPubMedCentralGoogle Scholar
  12. Campanozzi A, Boccia G, Pensabene L, et al. Prevalence and natural history of gastroesophageal reflux: pediatric prospective study. Pediatrics. 2009;123:779–83.PubMedCrossRefPubMedCentralGoogle Scholar
  13. Carroll A, Garrison MM, Christakis DA. A systematic review of nonpharmacological and nonsurgical therapies for gastroesophageal reflux in infants. Arch Pediatr Adolesc Med. 2002;156:109–13.PubMedCrossRefPubMedCentralGoogle Scholar
  14. Castellani C, Huber-Zeyringer A, Saxena AK, et al. Omeprazole for reflux in infants: effectiveness determined by impedance-pH monitoring. Pediatr Surg Int. 2014;30:381–5.PubMedCrossRefPubMedCentralGoogle Scholar
  15. Chang AB, Lasserson TJ, Gaffney J, et al. Gastro-oesophageal reflux treatment for prolonged nonspecific cough in children and adults. Cochrane Database Syst Rev. 2006;4:1–46.Google Scholar
  16. Chen S, Jarboe MD, Teitelbaum DH. Effectiveness of a transluminal endoscopic fundoplication for the treatment of pediatric gastroesophageal reflux disease. Pediatr Surg Int. 2012;28:229–34.PubMedCrossRefPubMedCentralGoogle Scholar
  17. Corvaglia L, Rotatori R, Ferlini M, et al. The effect of body positioning on gastroesophageal reflux in premature infants: evaluation by combined impedance and pH monitoring. J Pediatr. 2007;151:591–6.PubMedCrossRefPubMedCentralGoogle Scholar
  18. Cossentino MJ, Mann K, Armbruster SP, et al. Randomized clinical trial: the effect of baclofen in patients with gastro-oesophageal reflux – a randomized prospective study. Aliment Pharmacol Ther. 2012;35:1036–44.PubMedPubMedCentralGoogle Scholar
  19. Dellon ES. Diagnosis and management of eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2012;10:1066–78.PubMedPubMedCentralCrossRefGoogle Scholar
  20. Dent J. A new technique for continuous sphincter pressure measurement. Gastroenterology. 1976;71:263–7.PubMedCrossRefPubMedCentralGoogle Scholar
  21. Dent EL, Serag HB, Wallander MA, et al. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2005;54:710–7.PubMedPubMedCentralCrossRefGoogle Scholar
  22. Di Fiore JM, Arko M, Whitehouse M, et al. Apnea is not prolonged by acid gastroesophageal reflux in preterm infants. Pediatrics. 2005;116:1059–63.PubMedCrossRefPubMedCentralGoogle Scholar
  23. Dodds WJ, Stewart ET, Hogan WJ, et al. Effect of esophageal movement on intraluminal esophageal pressure recording. Gastroenterology. 1974;67:592–600.PubMedCrossRefPubMedCentralGoogle Scholar
  24. Donnellan C, Preston C, Moayyedi P, et al. Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease. Cochrane Database Syst Rev. 2004;4:1–58.Google Scholar
  25. Dranove JE, Horn DS, Davis MA, et al. Predictors of response to proton pump inhibitor therapy among children with significant esophageal eosinophilia. J Pediatr. 2009;154:96–100.PubMedCrossRefPubMedCentralGoogle Scholar
  26. Edwards DAW. The anti-reflux mechanism, its disorders and their consequences. Clin Gastroenterol. 1982;11:479–96.PubMedPubMedCentralGoogle Scholar
  27. El-Serag HB, Richardson P, Pilgrim P, et al. Determinants of gastroesophageal reflux disease in adults with a history of childhood gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2007;5:696–701.PubMedCrossRefPubMedCentralGoogle Scholar
  28. Field SK, Gary CM, Gelfand AJ, et al. The effects of antireflux surgery on asthmatics with gastroesophageal reflux. Chest. 1999;116:766–74.PubMedCrossRefPubMedCentralGoogle Scholar
  29. Forsell L, Cnattingius S, Bottai M, et al. Increased risk of Barrett’s esophagus among individuals born preterm or small for gestational age. Clin Gastroenterol Hepatol. 2013;11:790–4.CrossRefGoogle Scholar
  30. Fujiwara Y, Arakawa T, Fass R. Gastroesophageal reflux and sleep. Gastroenterol Clin N Am. 2013;42:57–70.CrossRefGoogle Scholar
  31. Fukahori S, Asagiri K, Ishii S, et al. Pre-and postoperative evaluation of gastroesophageal reflux and esophageal motility in neurologically impaired children using combined pH-multichannel intraluminal impedance measurement. Pediatr Surg Int. 2013;29:545–51.PubMedPubMedCentralCrossRefGoogle Scholar
  32. Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systemic review and consensus recommendation for diagnosis and treatment. Gastroenterology. 2007;133:1342–63.PubMedCrossRefGoogle Scholar
  33. Ganz RA, Peters JH, Horgan S, et al. Esophageal sphincter device for gastroesophageal reflux disease. N Engl J Med. 2013;368:719–27.PubMedCrossRefGoogle Scholar
  34. Genta RM, Spechler SJ, Kielhorn AF. The Los Angeles and Savary-Miller systems for grading esophagitis: utilization and correlation with histology. Dis Esophagus. 2011;24:10–7.PubMedCrossRefGoogle Scholar
  35. Georgeson KE. Gastroesophageal reflux and hiatal hernia. In: Puri P, Höllwarth M, editors. Pediatric surgery, Springer Atlas series. Berlin/Heidelberg/New York: Springer; 2006. p. 49–60.Google Scholar
  36. Goessler A, Huber-Zeyringer A, Hoellwarth ME. Does epilepsy influence the outcome of antireflux procedures in neurologically impaired children. Pediatr Surg Int. 2006;22:485–90.PubMedCrossRefGoogle Scholar
  37. Goessler A, Schalamon J, Huber-Zeyringer A, et al. Gastroesophageal reflux and behaviour in neurologically impaired children. J Pediatr Surg. 2007;42:1486–90.CrossRefGoogle Scholar
  38. Gold BD. Is gastroesophageal reflux disease really a life-long disease: do babies who regurgitate grow up to be adults with GERD complications. Am J Gastroenterol. 2006;101:641–4.PubMedCrossRefGoogle Scholar
  39. Gonsalves AN, Yang GY, Doerfler B, et al. Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology. 2012;142:1451–9.PubMedCrossRefGoogle Scholar
  40. Gupta M, Iyer PG, Lutzke L, et al. Recurrence of esophageal intestinal metaplasia after endoscopic mucosal resection and radiofrequency ablation of Barrett’s esophagus: results from a US Multicenter Consortium. Gastroenterology. 2013;145:79–86.PubMedPubMedCentralCrossRefGoogle Scholar
  41. Hassall E. Barrett’s esophagus: new definitions and approaches in children. J Pediatr Gastroenterol Nutr. 1993;16:345–64.PubMedCrossRefGoogle Scholar
  42. Hassall E. Outcomes of fundoplication: cause for concern, newer options. Arch Dis Child. 2005;90:1047–52.PubMedPubMedCentralCrossRefGoogle Scholar
  43. Hassall E, Kerr W, El-Serag H. Characteristics of children receiving proton pump inhibitors continuously for up to 11 years duration. J Pediatr. 2007;150:262–7.PubMedCrossRefGoogle Scholar
  44. Hirsch DP, Holloway RH, Tytgat GN, et al. Involvement of nitric oxide in human transient lower esophageal sphincter relaxations and esophageal primary peristalsis. Gastroenterology. 1998;115:1374–80.PubMedCrossRefGoogle Scholar
  45. Höllwarth ME. Entwicklung der Speiseröhrenfunktion bei Neugeborenen – eine manometrische Untersuchung. Z Kinderchir. 1979;27:201–15.Google Scholar
  46. Höllwarth M. Gastroösophagealer Reflux und Erkrankungen des Magens. In: von Schweinitz D, Ure B, editors. Kinderchirurgie. 2nd ed. Berlin/Heidelberg: Springer; 2009.Google Scholar
  47. Höllwarth ME, Uray E. Physiology and pathophysiology of the esophagus in childhood. Pediatr Surg Int. 1985;18:1–13.Google Scholar
  48. Höllwarth ME, Uray E, Pesendorfer P. Esophageal manometry. Pediatr Surg Int. 1986;1:177–83.Google Scholar
  49. Horvath A, Dziechciarz P, Szajewska H. The effect of thickened-feed interventions on gastroesophageal reflux in infants: systematic review and meta-analysis of randomized controlled trials. Pediatrics. 2008;112:e1268–77.CrossRefGoogle Scholar
  50. Jodorkovsky D, Price JC, Kim B, et al. Multichannel intraluminal impedance-pH testing is clinically useful in the management of patients with gastroesophageal reflux symptoms. Dig Dis Sci. 2014;23. Epub ahead of print.Google Scholar
  51. Johnson DA, Ganz R, Aisenberg J, et al. Endoscopic implantation of Enteryx for treatment of GERD: 12-month results of a prospective, multicenter trial. Am J Gastroenterol. 2003;98:1921–30.PubMedCrossRefPubMedCentralGoogle Scholar
  52. Kahrilas PJ, Shaheen NJ, Vaezi MF, et al. American Gastroenterological Association medical position statement on the management of gastroesophageal reflux disease. Gastroenterology. 2008;135:1383–91.PubMedCrossRefPubMedCentralGoogle Scholar
  53. Katz PO. Gastroesophageal reflux disease: new treatments (review). Rev Gastroenterol Disord. 2002;2:66–74.PubMedPubMedCentralGoogle Scholar
  54. Khoshoo V, Le T, Haydel RM Jr, et al. Role of GER in older children with persistent asthma. Chest. 2003;123:1008–13.PubMedCrossRefGoogle Scholar
  55. Kurz R, Höllwarth ME, Fasching G, et al. Combined disturbance of respiratory regulation and esophageal function in early infancy. Prog Pediatr Surg. 1985;18:52–61.PubMedCrossRefGoogle Scholar
  56. Landler U, Höllwarth ME, Uray E, et al. Esophageal function in infants with sudden infant death risk. Klin Pädiatr. 1990;202:37–42.PubMedCrossRefGoogle Scholar
  57. Lasser MS, Liao JG, Burd RS. National trends in the use of antireflux procedures for children. Pediatrics. 2006;118:1828–35.PubMedCrossRefGoogle Scholar
  58. Lee WS, Beattie RM, Meadows M, et al. Gastro-oesophageal reflux: clinical profiles and outcome. J Paediatr Child Health. 1999;35:568–71.PubMedCrossRefGoogle Scholar
  59. Lidums I, Lehmann A, Checklin H, et al. Control of transient lower esophageal sphincter relaxations and reflux by the GABAB agonist baclofen in normal subjects. Gastroenterology. 2000;118:7–13.PubMedCrossRefGoogle Scholar
  60. Liebermann-Meffert D, Allgöwer M, Schmid P, et al. Muscular equivalent of the lower esophageal sphincter. Gastroenterology. 1979;76:31–8.PubMedPubMedCentralGoogle Scholar
  61. Liu DC, Somme S, Mavrelis PG, et al. Stretta as the initial antireflux procedure in children. J Pediatr Surg. 2005;40:148–52.PubMedCrossRefPubMedCentralGoogle Scholar
  62. Lo W-K, Chan WW. Proton pump inhibitor use and the risk of small bacterial overgrowth: a meta-analysis. Clin Gastroenterol Hepatol. 2013;11:483–90.PubMedCrossRefPubMedCentralGoogle Scholar
  63. Lundell L, Miettinen P, Myrvold HE, et al. Continued (5 year) followup of a randomized clinical study comparing antireflux surgery and omeprazole in gastroesophageal reflux disease. J Am Coll Surg. 2001;192:172–81.PubMedCrossRefPubMedCentralGoogle Scholar
  64. Martin AJ, Pratt N, Kennedy DJ, et al. Natural history and familial relationship of infants spilling to 9 years of age. Pediatrics. 2002;109:1061–7.PubMedCrossRefPubMedCentralGoogle Scholar
  65. Mathisen B, Worall I, Masel J, et al. Feeding problems in infants with gastro-oesophageal reflux disease: a controlled study. J Paediatr Child Health. 1999;35:163–9.PubMedCrossRefPubMedCentralGoogle Scholar
  66. Mittal RK, Balaban DH. The esophagogastric junction. N Engl J Med. 1997;336:924–32.PubMedCrossRefPubMedCentralGoogle Scholar
  67. Morabito A, Lall A, Piccolo RL, et al. Total esophagogastric dissociation: 10 years’ review. J Pediatr Surg. 2006;41:919–22.PubMedCrossRefPubMedCentralGoogle Scholar
  68. Nakahara Y, Aoyama K, Goto T, et al. Modified Collis-Nissen procedure for pure long-gap esophageal atresia. J Pediatr Surg. 2012;47:262–6.CrossRefGoogle Scholar
  69. Ngerncham M, Barnhart DC, Haricharan RN, et al. Risk factors for recurrent gastroesophageal reflux disease after fundoplication in pediatric patients: a case-control study. J Pediatr Surg. 2007;42:1478–85.PubMedCrossRefPubMedCentralGoogle Scholar
  70. Nissen R. A simple operation for control of reflux esophagitis. Schweiz Med Wochenschr. 1956;81(Suppl 20):590–2.Google Scholar
  71. Ollyo JB, Savary M, Levi F. Esophagitis caused by stenosing reflux: importance of endoscopy for diagnosis and surveillance. Schweiz Rundsch Med Prax. 1986;75:1528–30.PubMedPubMedCentralGoogle Scholar
  72. Omari TI, Barnett CP, Benninga MA, et al. Mechanism of gastroesophageal reflux in preterm and term infants with reflux disease. Gut. 2002;51:475–9.PubMedPubMedCentralCrossRefGoogle Scholar
  73. Omari TI, Benninga MA, Sansom L, et al. Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: a randomized controlled trial. J Pediatr. 2006;149:468–74.PubMedCrossRefPubMedCentralGoogle Scholar
  74. Orenstein SR, Shalaby TM, Kelsey SF, et al. Natural history of infant reflux esophagitis: symptoms and morphometric histology during one year without pharmacotherapy. Am J Gastroenterol. 2006;101:628–40.PubMedCrossRefPubMedCentralGoogle Scholar
  75. Pandolfino JE, Krishnan K. Do endoscopic antireflux procedures fit in the current treatment paradigm of gastroesophageal reflux disease? Clin Gastroenterol Hepatol. 2014;12:544–54.PubMedCrossRefPubMedCentralGoogle Scholar
  76. Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143:1051–187.CrossRefGoogle Scholar
  77. Pesendorfer P, Höllwarth ME, Uray E. Long-term follow-up in infants with pathological gastroesophageal reflux. Klin Pädiatr. 1993;205:363–6.PubMedCrossRefPubMedCentralGoogle Scholar
  78. Raicevic M, Saxena AK. Barrett’s esophagus in children: what is the evidence? World J Pediatr. 2018;14(4):330–4.PubMedCrossRefPubMedCentralGoogle Scholar
  79. Rees JRE, Lao-Sireix P, Wong A, et al. Treatment of Barrett oesophagus. Cochrane Database Syst Rev. 2010;1:1–59.Google Scholar
  80. Richter JE. Gastroesophageal reflux disease treatment: side effects and complications of fundoplication. Clin Gastroenterol Hepatol. 2013;11:465–71.PubMedCrossRefPubMedCentralGoogle Scholar
  81. Rodriguez L, Rodriguez P, Gomez P, et al. Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: final result of open-label prospective trial. Surg Endosc. 2013;27:1038–92.CrossRefGoogle Scholar
  82. Rudolph CD. Are proton pump inhibitors indicated for the treatment of gastroesophageal reflux in infants and children? J Pediatr Gastroenterol Nutr. 2003;37(Suppl):S60–4.PubMedCrossRefPubMedCentralGoogle Scholar
  83. Sampliner RE. Practice guidelines on the diagnosis, surveillance, and therapy of Barrett’s esophagus. The Practice Parameters Committee of the American College of Gastroenterology. Am J Gastroenterol. 1998;93:1028–32.PubMedCrossRefPubMedCentralGoogle Scholar
  84. Semeniuk J, Kaczmarski M. 24-hour esophageal pH-monitoring in children suspected of gastroesophageal reflux disease: analysis of intraesophageal pH monitoring values recorded in distal and proximal channel at diagnosis. World J Gastroenterol. 2007;13:5108–15.PubMedPubMedCentralCrossRefGoogle Scholar
  85. Sherman PM, Hassal E, Fagundes-Neto U, et al. A global, evidence-based consensus on the definition of gastroesophageal reflux disease in the pediatric population. Am J Gastroenterol. 2009;104:1278–95.PubMedCrossRefPubMedCentralGoogle Scholar
  86. Slocum C, Hibbs AM, Martin RJ, et al. Infant apnea and gastroesophageal reflux: a critical review and framework for further investigation. Curr Gastroenterol Rep. 2007;9:219–24.PubMedCrossRefPubMedCentralGoogle Scholar
  87. Solayamani-Dodaran M, Card TR, West J. Cause-specific mortality of people with Barrett’s esophagus compared with the general population: a population based cohort study. Gastroenterology. 2013;144:1375–82.CrossRefGoogle Scholar
  88. Sopo SM, Radzik D, Calvani M. Does treatment with proton pump inhibitors for gastroesophageal reflux disease (GERD) improve asthma symptoms in children with asthma and GERD? A systematic review. J Investig Allergol Clin Immunol. 2009;19:1–5.PubMedPubMedCentralGoogle Scholar
  89. Strate U, Emmermann A, Fibbe C, et al. Laparoscopic fundoplication: Nissen versus Toupet two-year outcome of a prospective randomized study of 200 patients regarding preoperative esophageal motility. Surg Endosc. 2008;22:21–30.PubMedCrossRefPubMedCentralGoogle Scholar
  90. Thal AP, Hatafuku T, Kurtzman R. New operation for distal esophageal stricture. Arch Surg. 1965;90:464–72.PubMedCrossRefPubMedCentralGoogle Scholar
  91. Tolia V, Boyer K. Long-term proton pump inhibitor use in children: a retrospective review of safety. Dig Dis Sci. 2008;53:385–93.PubMedCrossRefPubMedCentralGoogle Scholar
  92. Toupet A. Technique d’esophago-gastroplastie avec phreno-gastropexiedans la cure radicals des hernieshiatales et comme complement de l’operation de Heller dans les cardiospasmes. Mem Acad Chir. 1963;89:394–9.Google Scholar
  93. Tovar JA, Luis AL, Encinas JL, et al. Pediatric surgeons and gastroesophageal reflux. J Pediatr Surg. 2007;42:277–83.PubMedCrossRefPubMedCentralGoogle Scholar
  94. Ummarino D, Miele E, Masi P, et al. Impact of antisecretory treatment on respiratory symptoms of gastroesophageal reflux disease in children. Dis Esophagus. 2012;25:671–7.PubMedCrossRefPubMedCentralGoogle Scholar
  95. Vadlamudi NB, Hitch MC, Dimmitt RA, et al. Baclofen for the treatment of pediatric GERD. JPGN. 2013;57:808–12.PubMedPubMedCentralGoogle Scholar
  96. Vaezi MF. Sore throat and a red hypopharynx: is it reflux? Clin Gastroenterol Hepatol. 2007;5:1379–82.PubMedCrossRefPubMedCentralGoogle Scholar
  97. van der Pol RJ, Loots CM, Peeters L, et al. Outcomes of endoscopy and novel pH-impedance parameters in children: is there a correlation? JPGN. 2013;56:196–200.PubMedPubMedCentralGoogle Scholar
  98. Vandenplas Y, Goyvaerts H, Helven R. Gastroesophageal reflux, as measured by 24-hour pH-monitoring, in 509 healthy infants screened for risk of sudden infant death syndrome. Pediatrics. 1991;88:834–40.PubMedPubMedCentralGoogle Scholar
  99. Vandenplas Y, Salvatore S, Devreker T, et al. Gastro-oesophageal reflux disease: oesophageal impedance versus pH monitoring. Acta Paediatr. 2007;96:956–62.PubMedCrossRefPubMedCentralGoogle Scholar
  100. Vandenplas Y, Rudolph CD, Di Lorenzo C, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. 2009;49:498–547.PubMedCrossRefPubMedCentralGoogle Scholar
  101. Vernon-Roberts A, Sullivan PB. Fundoplication versus post-operative medication for gastro-oesophageal reflux in children with neurological impairment undergoing gastrostomy (review). Cochrane Database Syst Rev. 2007;1:1–13.Google Scholar
  102. Wasilewska A, Semeniuk J, Cudowska P, et al. Respiratory response to proton pump inhibitor treatment in children with obstructive sleep apnea syndrome and gastroesophageal reflux. Sleep Med. 2012;13:824–30.PubMedCrossRefPubMedCentralGoogle Scholar
  103. Weber TR. A prospective analysis of factors influencing outcome after fundoplication. J Pediatr Surg. 1995;30:1061–4.PubMedCrossRefPubMedCentralGoogle Scholar
  104. Wenzel TG, Benninga MA, Loots CM, et al. Indications, methodology, and interpretation of combined esophageal impedance-pH monitoring in children: ESPGHAN EURO-PIG standard protocol. J Pediatr Gastroenterol Nutr. 2012;55:230–4.CrossRefGoogle Scholar
  105. Wenzl TG, Schenke S, Peschgens T, et al. Association of apnea and non-acid gastroesophageal reflux in infants: investigations with intraluminal impedance technique. Pediatr Pulmonol. 2001;31:144–9.PubMedCrossRefPubMedCentralGoogle Scholar
  106. Xu X-H, Yang Z-M, Chen Q, et al. Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough. World J Gastroenterol. 2013;19:4368–92.Google Scholar
  107. Zhang Q, Lehmann A, Rigda R, et al. Control of transient lower oesophageal sphincter relaxations and reflux by the GABAB agonist baclofen in patients with gastro-oesophageal reflux disease. Gut. 2002;50:19–24.PubMedPubMedCentralCrossRefGoogle Scholar

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© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of Paediatric and Adolescent SurgeryMedical University of GrazGrazAustria
  2. 2.Department of Pediatric RadiologyMedical University of GrazGrazAustria

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