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HIV-Infektion/AIDS: Neurologische Aspekte

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Klinische Neurologie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Die HIV-Infektion ist eine durch das humane Immundefizienzvirus (HIV) hervorgerufene Krankheit, die seit Anfang der 80er-Jahre des vorigen Jahrhunderts bekannt ist, seit 1984 durch Antikörpertests diagnostiziert werden kann und seit 1996, als die modernen hochaktiven antiretroviralen Kombinationstherapien (HAART) eingeführt wurden, zu einer behandelbaren chronischen Erkrankung geworden ist. Seit 2005 bezeichnet man die Therapie als cART („combination antiretroviral therapy“). UN-AIDS veröffentlichte 2014 die Zielvorgabe, dass bis 2020 90 % aller HIV-Infektionen weltweit diagnostiziert und 90 % antiretroviral behandelt sein sollen, davon ebenfalls 90 % erfolgreich (Viruslast im Blut unterhalb der Nachweisgrenze), eine Forderung, die in Deutschland nahezu umgesetzt ist.

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Literatur

  • Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69(18):1789–1799

    Article  CAS  Google Scholar 

  • Arendt G, Nolting T, Frisch C, Husstedt IW, Gregor N, Koutsilieri E, Maschke M, Angerer A, Obermann M, Neuen-Jacob E, Adams O, Loeffert S, Riederer P, ter Meulen V, Sopper S (2007) Intrathecal viral replication and cerebral deficits in different stages of human immunodeficiency virus disease. J Neurovirol 13(3):225–232

    Article  Google Scholar 

  • Arendt G, Schlonies S, Orhan E, Stüve O (2019) Simplification of combination antiretroviral therapy (cART) and the brain – a real life experience. J Neurovirol 25(2):174–182

    Article  Google Scholar 

  • Aziz-Donnelly A, Harrison TB (2017) Update of HIV-associated sensory neuropathies. Curr Treat Options Neurol 19(10):36

    Article  Google Scholar 

  • Brew BJ, Crowe SM, Landay A, Cysique LA, Guillemin G (2009) Neurodegeneration and ageing in the HAART era. J Neuroimmune Pharmacol 4(2):163–174

    Article  Google Scholar 

  • Cysique LA, Brew BJ (2019) Vascular cognitive impairment and HIV-associated neurocognitive disorder: a new paradigm. J Neurovirol. https://doi.org/10.1007/s13365-018-0706-5. [Epub vor Druck]

  • Cysique L, Casaletto LB, Heaton RK (2019) Reliably measuring cognitive change in the era of chronic HIV infection and chronic HIV-associated neurocognitive disorders. Curr Top Behav Neurosci. https://doi.org/10.1007/7854_2019_116. [Epub vor Druck]

  • Dore GJ, Li Y, McDonald A, Ree H, Kaldor JM (2003) Impact of highly active antiretroviral therapy on individual AIDS-defining illness incidence and survival in Australia. J Acquir Immune Defic Syndr 29(4):388–395

    Article  Google Scholar 

  • Goudsmit J, de Wolf F, Paul DA, Epstein LG, Lange JM, Krone WJ, Speelman H, Wolters EC, Van der Noordaa J, Oleske JM et al (1986) Expression of human immunodeficiency virus antigen (HIV-Ag) in serum and cerebrospinal fluid during acute and chronic infection. Lancet 2(8500):177–180

    Article  CAS  Google Scholar 

  • Heywood W, Lyons A (2016) HIV and elevated mental health problems: diagnostic, treatment and risk patterns for symptoms of depression, anxiety and stress in a national community-based cohort of gay men living with HIV. AIDS Behav 20:1632–1645

    Article  Google Scholar 

  • Joint United Nations Programme on HIV/AIDS (2014) 90-90-90: an ambitious treatment target to help end the AIDS epidemic. UNAIDS, Geneva

    Google Scholar 

  • Kaida K, Ariga T, Yu RK (2009) Antiganglioside antibodies and their pathophysiological effects on Guillain-Barre syndrome and related disorders – a review. Glycobiology 19(7):676–692

    Article  CAS  Google Scholar 

  • Kaku M, Simpson D (2018) Neuromuscular complications of HIV infection. Handb Clin Neurol 152:201–212

    Article  Google Scholar 

  • Letendre S, Marquie-Beck J, Capparelli E, Best B, Clifford D, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Simpson D, Grant I, Ellis RJ, CHARTER Group (2008) Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol 65(1):65–70

    Article  Google Scholar 

  • Moodley K, Bill PL, Patel VB (2016) A comparative study of CIDP in a cohort of HIV-infected and HIV-uninfected patients. Neurol Neuroimmunol Neuroinflamm 4(2):e315

    Article  Google Scholar 

  • Murdoch DM, Suchard MS, Venter WD, Mhlangu P, Ottinger JS, Feldman C, Van Rie A, Glencross DK, Stevens WS, Weinhold KJ (2009) Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS). AIDS Res Ther 6:16

    Article  Google Scholar 

  • Prior DE, Song N, Cohen JA (2018) Neuromuscular diseases associated with human immunodeficiency virus infection. Neurol Sci 387:27–36

    Article  CAS  Google Scholar 

  • Sereti I, Sheikh V, Shaffler D, Phanupak N, Gabriel E, Warig J, Nason MC, Roby G, Ngeno H, Kirui F, Pau A, Mican JM, Rupert A, Bishop R, Agan B, Chomchey N, Teeratakulpisam N, Tansuphaswadiku S, Langat D, Kosgei J, French M, Ananworanich J, Sawe F, IRIS NIAID/IDCRP team (2019) Prospective international study of incidence and predictors if immune reconstitution inflammatory syndrome and death in people with HIV and severe lymphopenia. Clin Infect Dis. [Epub vor Druck]

    Google Scholar 

  • Shelburne SA 3rd, Hamill RJ (2003) The immune reconstitution inflammatory syndrome. AIDS Rev 5(2):67–79

    PubMed  Google Scholar 

  • Sico JJ, Chang CC, So-Armah K, Justice AC, Hylek E, Skanderson M, McGinnis K, Kuller LH, Kraemer KL, Rimland D, Bidwell Goetz M, Butt AA, Rodriguez-Barradas MC, Gibert C, Leaf D, Brown ST, Samet J, Kazis L, Bryant K, Freiberg MS, Veterans Aging Cohort Study (2015) HIV status and the risk of ischemic stroke among men. Neurology 84:1933–1940

    Article  Google Scholar 

  • Smith DM, Zarate S, Shao H, Pillai SK, Letendre SL, Wong JK, Richman DD, Frost SD, Ellis RJ (2009) Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populations. Virology 385(1):204–208

    Article  CAS  Google Scholar 

  • Verma A (2001) Epidemiology and clinical features of HIV-1 associated neuropathies. J Peripher Nerv Syst 6(1):8–13

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Neurologische Klinik, Heinrich-Heine-Universität, Düsseldorf, Deutschland

    Gabriele Arendt

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  1. Gabriele Arendt
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Correspondence to Gabriele Arendt .

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  1. Essen, Germany

    Peter Berlit

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Arendt, G. (2020). HIV-Infektion/AIDS: Neurologische Aspekte. In: Berlit, P. (eds) Klinische Neurologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44768-0_104-1

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  • DOI: https://doi.org/10.1007/978-3-662-44768-0_104-1

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  • Print ISBN: 978-3-662-44768-0

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