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Gerinnungsstörungen in der Neurologie

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Book cover Klinische Neurologie

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Zusammenfassung

Das menschliche Hämostasesystem befindet sich physiologischerweise in einem natürlichen Gleichgewicht zwischen pro- und antithrombotischen Prozessen, um einerseits im Falle einer Verletzung durch eine schnelle Gerinnselbildung ein Verbluten zu verhindern, andererseits aber auch den Blutfluss aufrechtzuerhalten. Dies wird mit genau gesteuerten Regelkreisen, die die hämostasefördernden und die gegenläufigen hämostasehemmenden Prozesse in einem fein austarierten Gleichgewicht halten, erreicht. Ein Ungleichgewicht in diesem komplexen System führt auf der einen Seite zu hämorrhagischen Diathesen mit dem Risiko von Blutungen und auf der anderen Seite zu thrombophilen Diathesen mit dem Risiko von Thrombosen und Embolien. Beide Situationen können hereditär, genetisch determiniert, oder sekundär, erworben, auftreten. Die korrekte Diagnosestellung ist aufgrund der hohen klinischen Varianz der Krankheitsbilder komplex. Die klinische Forschung identifiziert zudem immer mehr Ursachen von hämostaseologischen Störungen. Demgegenüber stehen aber auch stetige Neuentwicklungen von medikamentösen Therapien für alle Bereiche der Hämostaseologie, insbesondere auf dem Gebiet der Antikoagulanzien und Orphan Drugs.

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Literatur

  • Balduini CL, Savoia A (2012) Genetics of familial forms of thrombocytopenia. Hum Genet 131(12):1821–1832. https://doi.org/10.1007/s00439-012-1215-x. Epub 2012 Aug 11

    Article  CAS  PubMed  Google Scholar 

  • Brinjikji W, Iyer VN, Wood CP, Lanzino G (2017) Prevalence and characteristics of brain arteriovenous malformations in hereditary hemorrhagic telangiectasia: a systematic review and meta-analysis. J Neurosurg 127(2)

    Article  Google Scholar 

  • Cohen YC, Djulbegovic B, Shamai-Lubovitz I et al (1998) The natural history of severe idiopathic thrombocytopenic purpura. Blood 92(Suppl 1):177a

    Google Scholar 

  • Connolly SJ, Ezekowitz MD, Yusuf S et al (2009) Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361:1139–1151

    Article  CAS  Google Scholar 

  • Cottin V, Chinet T, Lavolé A et al (2007) Pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia: a series of 126 patients. Medicine (Baltimore) 86:1–17

    Article  Google Scholar 

  • Dlott JS, Roubey RA (2012) Drug-induced lupus anticoagulants and antiphospholipid antibodies. Curr Rheumatol Rep 14(1):71–78

    Article  CAS  Google Scholar 

  • Douketis JD, Gu C, Piccioli A, Ghirarduzzi A, Pengo V, Prandoni P (2009) The long-term risk of cancer in patients with a first episode of venous thromboembolism. J Thromb Haemost 7(4):546–551. https://doi.org/10.1111/j.1538-7836.2008.03268.x. Epub 2008 Dec 22

    Article  CAS  PubMed  Google Scholar 

  • Frontera JA, Lewin JJ, Rabinstein AA, Aisiku IP, Alexandrov AW, Cook AM, del Zoppo GJ, Kumar MA, Peerschke EI, Stiefel MF, Teitelbaum JS, Wartenberg KE, Zerfoss CL (2016) Guideline for reversal of antithrombotics in intracranial hemorrhage: a statement for healthcare professionals from the Neurocritical Care Society and Society of Critical Care Medicine. Neurocrit Care 24(1):6–46

    Article  CAS  Google Scholar 

  • Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, Creager MA, Culebras A, Eckel RH, Hart RG, Hinchey JA, Howard VJ, Jauch EC, Levine SR, Meschia JF, Moore WS, Nixon JV, Pearson TA, American Heart Association Stroke Council, Council on Cardiovascular Nursing, Council on Epidemiology and Prevention, Council for High Blood Pressure Research, Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research (2011) Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 42(2):517–584. https://doi.org/10.1161/STR.0b013e3181fcb238. Epub 2010 Dec 2

    Article  PubMed  Google Scholar 

  • Granger CB et al (2011) Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 365(11):981–982.5

    Article  CAS  Google Scholar 

  • Herold G (1999) Innere Medizin. Eigenverlag, Köln

    Google Scholar 

  • Jiang B, Ryan KA, Hamedani A, Cheng Y, Sparks MJ, Koontz D, Bean CJ, Gallagher M, Hooper WC, McArdle PF, O’Connell JR, Stine OC, Wozniak MA, Stern BJ, Mitchell BD, Kittner SJ, Cole JW (2014) Prothrombin G20210A mutation is associated with young-onset stroke: the genetics of early-onset stroke study and meta-analysis. Stroke 45(4):961–967. https://doi.org/10.1161/STROKEAHA.113.004063. Epub 2014 Mar 11

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kase CS, Mohr JP, Caplan LR (2004) Intracerebral hemorrhage. In: Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PA (Hrsg) Stroke–pathophysiology, diagnosis, and management, 4. Aufl. ChurchillLivingstone, Philadelphia, S 327–376

    Google Scholar 

  • Kim H et al (2004) Analysis of fatal intracranial hemorrhage in 792 acute leukemia patients. Haematologica 89:622–624

    PubMed  Google Scholar 

  • Kosik KS, Furie B (1980) Thrombotic stroke associated with elevated plasma factor VIII. Ann Neurol 8(4):435–437

    Article  CAS  Google Scholar 

  • Lalouschek W, Schillinger M, Hsieh K, Endler G, Tentschert S, Lang W, Cheng S, Mannhalter C (2005) Matched case-control study on factor V Leiden and the prothrombin G20210A mutation in patients with ischemic stroke/transient ischemic attack up to the age of 60 years. Stroke 36(7):1405–1409. Epub 2005 Jun 9

    Article  Google Scholar 

  • Lau LM de, Leebeek FW, de Maat MP, Koudstaal PJ, Dippel DW (2010) A review of hereditary and acquired coagulation disorders in the aetiology of ischaemic stroke. Int J Stroke 5(5):385–394. https://doi.org/10.1111/j.1747-4949.2010.00468

  • Loirat C, Frémeaux-Bacchi V (2011) Atypical hemolytic uremic syndrome. Orphanet J Rare Dis 6:60. https://doi.org/10.1186/1750-1172-6-60

    Article  PubMed  PubMed Central  Google Scholar 

  • Martinez HR, Rangel-Guerra RA, Marfil LJ (1993) Ischemic stroke due to deficiency of coagulation inhibitors. Report of 10 young adults. Stroke 24:19–25

    Article  CAS  Google Scholar 

  • Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, Brinkmann V, Lorenz M, Bidzhekov K, Khandagale AB, Konrad I, Kennerknecht E, Reges K, Holdenrieder S, Braun S, Reinhardt C, Spannagl M, Preissner KT, Engelmann B (2010) Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med 16:887–896

    Article  CAS  Google Scholar 

  • Miyakis S, Lockshin MD, Atsumi D, Ranch DW, Brey RL, Cervera R (2006) International consensus statement on an updade of the preliminary classification criteria for antiphospholipid syndrome (APS). J Thromb Haemost 4:295–306

    Article  CAS  Google Scholar 

  • Othman M (2011) Platelet type von Willebrand disease: a rare, often misdiagnosed and underdiagnosed bleeding disorder. Semin Thromb Hemost 37(5):464–469. https://doi.org/10.1055/s-0031-1281030. Epub 2011 Nov 18

    Article  CAS  PubMed  Google Scholar 

  • Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, Breithardt G, Halperin JL, Hankey GJ, Piccini JP, Becker RC, Nessel CC, Paolini JF, Berkowitz SD, Fox KA, Califf RM, Investigators ROCKETAF (2011) Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 365(10):883–891. https://doi.org/10.1056/NEJMoa1009638. Epub 2011 Aug 10

    Article  CAS  PubMed  Google Scholar 

  • Portielje JEA, Westendorp RGJ, Kluin-Nelemans HC et al (2001) Morbidity and mortality in adults with idiopathic thrombocytopenic purpura. Blood 97:2549–2554

    Article  CAS  Google Scholar 

  • Riede UN, Schaefer HE (1995) Allgemeine und spezielle Pathologie, 4. Aufl. Georg Thieme Verlag, Stuttgart/New York

    Google Scholar 

  • Robert P et al (2013) Edoxaban versus Warfarin in patients with atrial fibrillation. N Engl J Med 369:2093–2104

    Article  Google Scholar 

  • Schiller H, Bartscht T, Arlt A, Zahn MO, Seifert A, Bruhn T, Bruhn HD, Gieseler F (2002) Thrombin as a survival factor for cancer cells: thrombin activation in malignant effusions in vivo and inhibition of idarubicin-induced cell death in vitro. Int J Clin Pharmacol Ther 40(8):329–335

    Article  CAS  Google Scholar 

  • Shah H, Jan MU, Altaf A, Salahudin M (2018) Correlation of hyper-homocysteinemia with coronary artery disease in absence of conventional risk factors among young adults. J Saudi Heart Assoc 30(4):305–310. https://doi.org/10.1016/j.jsha.2018.04.002. Epub 2018 May 9

    Article  PubMed  PubMed Central  Google Scholar 

  • Steiner T, Dichgans M, Forsting M et al (2012) Intrazerebrale Blutun-gen. In: Diener HC, Weimar C, Berlit P et al (Hrsg) Leitlinien fürDiagnostik und Therapie in der Neurologie, 5. Aufl. Thieme, Stuttgart, S 380–397

    Google Scholar 

  • Steiner T, Bohm M, Dichgans M et al (2013) Recommendations for theemergency management of complications associated with new directoral anticoagulants (DOAC) apixaban, dabigatran, and rivaroxaban. Clin Res Cardiol 102:399–412

    Article  CAS  Google Scholar 

  • Szymańska M, Alhenc-Gelas M, Undas A (2013) Recurrent ischemic cerebrovascular events in a patient with type I antithrombin deficiency caused by 9788 G>A splice site mutation: a case report. Blood Coagul Fibrinolysis 24(2):213–215. https://doi.org/10.1097/MBC.0b013e32835b2467

    Article  PubMed  Google Scholar 

  • Van Den Berg YW, Reitsma PH (2011) Not exclusively tissue factor: neutrophil extracellular traps provide another link between chemotherapy and thrombosis. J Thromb Haemost 9(11):2311–2312. https://doi.org/10.1111/j.1538-7836.2011.04502.x

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Klinik für Neurologie, Krankenhaus Martha-Maria Halle-Dölau, Halle (Saale), Deutschland

    Andrea Kraft

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  1. Andrea Kraft
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Correspondence to Andrea Kraft .

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  1. Essen, Germany

    Peter Berlit

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Kraft, A. (2019). Gerinnungsstörungen in der Neurologie. In: Berlit, P. (eds) Klinische Neurologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44768-0_173-1

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  • DOI: https://doi.org/10.1007/978-3-662-44768-0_173-1

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  • Print ISBN: 978-3-662-44768-0

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