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Adnexal Tumors

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Braun-Falco´s Dermatology

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Abstract

The chapter summarizes important clinical and histological findings of cutaneous skin adnexal tumors. Thus, a well-trained clinician is able to diagnose some cutaneous adnexal tumors on the basis of clinical findings or at least is able to give a spectrum of relevant differential diagnosis. Depending on the morphological differentiation, a distinction is made between follicular tumors containing structures of the hair follicle, sweat gland tumors with eccrine or apocrine differentiation, and sebaceous skin tumors. In addition to benign tumors, the morphological criteria for malignant skin adnexal tumors are described. With regard to the different growth patterns and the biological behavior, we give important recommendations for biopsy technique and subsequent surgical treatment.

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References

Hair Follicle Tumors

  • Alomari A, Subtil A, Owen CE et al (2013) Solitary and multiple tumors of follicular infundibulum: a review of 168 cases with emphasis on staining patterns and clinical variants. J Cutan Pathol 40:532–537

    Article  PubMed  Google Scholar 

  • Bumgardner AC, Hsu S, Nunez-Gussman JK et al (2005) Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap. Int J Dermatol 44:415–417

    Article  PubMed  Google Scholar 

  • Costache M, Bresch M, Böer A (2008) Desmoplastic trichoepithelioma versus morphoeic basal cell carcinoma: a critical reappraisal of histomorphological and immunohistochemical criteria for differentiation. Histopathology 52:865–876

    Article  CAS  PubMed  Google Scholar 

  • Cribier B, Grosshans E (1995) Tumor of the follicular infundibulum: a clinicopathologic study. J Am Acad Dermatol 33:979–984

    Article  CAS  PubMed  Google Scholar 

  • Herrmann JL, Allan A, Trapp KM et al (2014) Pilomatrix carcinoma: 13 new cases and review of the literature with emphasis on predictors of metastasis. J Am Acad Dermatol 71:38–43

    Article  PubMed  Google Scholar 

  • Jedrych J, Leffell D, McNiff JM (2012) Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. J Cutan Pathol 39:317–323

    Article  PubMed  Google Scholar 

  • Julian CG, Bowers PW (1998) A clinical review of 209 pilomatricomas. J Am Acad Dermatol 39:191–195

    Article  CAS  PubMed  Google Scholar 

  • Kaddu S, Soyer P, Hödl S et al (1996) Morphological stages of pilomatricoma. Am J Dermatopathol 18:333–338

    Article  CAS  PubMed  Google Scholar 

  • Mamelak AJ, Goldberg LH, Katz TN et al (2010) Desmoplastic trichoepithelioma. J Am Acad Dermatol 62:102–106

    Article  PubMed  Google Scholar 

  • Mentzel T, Kutzner H, Requena L, Hartmann A (2010) Hauttumoren als Markerläsionen hereditärer Tumorsyndrome. Pathologe 31:489–496

    Article  CAS  PubMed  Google Scholar 

  • Misago N, Kimura T, Toda S et al (2010a) A revaluation of trichofolliculoma: the histopathological and immunohistochemical features. Am J Dermatopathol 32:35–43

    Article  PubMed  Google Scholar 

  • Misago N, Kimura T, Toda S et al (2010b) A revaluation of folliculosebaceous cystic hamartoma: the histopathologic and immunohistochemical features. Am J Dermatopathol 32:154–161

    Article  PubMed  Google Scholar 

  • Schulz T, Hartschuh W (1998) Folliculosebaceous cystic hamartoma is a trichofolliculoma at its very late stage. J Cutan Pathol 25:354–364

    Article  CAS  PubMed  Google Scholar 

  • Shimanovich I, Krahl D, Rose C (2010) Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors. J Am Acad Dermatol 62:277–283

    Article  PubMed  Google Scholar 

  • Tanboon J, Manonukul J, Pattanaprichakul P (2014) Melanocytic matricoma: two cases of a rare entity in women. J Cutan Pathol 41:775–782

    Article  PubMed  Google Scholar 

Sweat Gland Tumors

  • Arps DP, Chan MP, Patel RM et al (2015) Primary cutaneous cribriform carcinoma: report of six cases with clinicopathologic data and immunohistochemical profile. J Cutan Pathol 42:379–387

    Article  PubMed  Google Scholar 

  • Battistella M, Long leg L, Peltre B et al (2010) From hidroacanthoma simplex to poroid hidradenoma: clinicopathologic and immunohistochemic study of poroid neoplasms and reappraisal of their histogenesis. Am J Dermatopathol 32:459–468

    Article  PubMed  Google Scholar 

  • Brenn T (2015) Malignant sweat gland tumors: an update. Adv Anat Pathol 22:242–253

    Article  PubMed  Google Scholar 

  • Chang MD, Arthur AK, García JJ et al (2016) ETV6 rearrangement in a case of mammary analogue secretory carcinoma of the skin. J Cutan Pathol 43:1045–1049

    Article  PubMed  Google Scholar 

  • Coburn V, Radfar A, Snook D et al (2007) Cutaneous oncocytoma – a report of three cases and review of the literature. J Cutan Pathol 34:353–359

    Article  Google Scholar 

  • Dai B, Kong YY, Cai X et al (2014) Spiradenocarcinoma, cylindrocarcinoma and spiradenocylindrocarcinoma: a clinicopathological study of nine cases. Histopathology 65:658–666

    Article  PubMed  Google Scholar 

  • Duke WH, Sherrod TT, Lupton GP (2000) Aggressive digital papillary adenocarcinoma (aggressive digital papillary adenoma and adenocarcinoma revisited). Am J Surg Pathol 24:775–784

    Article  CAS  PubMed  Google Scholar 

  • Fox SB, Cotton DW (1992) Tubular apocrine adenoma and papillary eccrine adenoma. Entities or unity? Am J Dermatopathol 14:149–154

    Article  CAS  PubMed  Google Scholar 

  • Gabillot-Carre M, Weill F, Mamelle G et al (2006) Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis. Dermatology 212:221–228

    Article  CAS  PubMed  Google Scholar 

  • Granter SR, Seeger K, Calonje E et al (2000) Malignant eccrine spiradenoma (spiradenocarcinoma): a clinicopathologic study of 12 cases. Am J Dermatopathol 22:97–103

    Article  CAS  PubMed  Google Scholar 

  • Guitart J, Rosenbaum MM, Requena L (2003) “Eruptive syringoma”: a misnomer for a reactive eccrine gland ductal proliferation? J Cutan Pathol 30:202–205

    Article  CAS  PubMed  Google Scholar 

  • Hatta N, Yamada M, Hirano T et al (2008) Extramammary Paget’s disease: treatment, prognostic factors and outcome in 76 patients. Br J Dermatol 158:313–318

    CAS  PubMed  Google Scholar 

  • Held L, Mentzel T, Paredes B, Griewank K, Itzlinger-Monshi B, Rütten A (2019) Digitales papilläres Adenokarzinom. Vier Fallberichte mit kurzer Literaturübersicht. Hautarzt 70:204–209

    Article  CAS  PubMed  Google Scholar 

  • Huang S, Liu Y, Su J et al (2016) “Secretory” carcinoma of the skin mimicking secretory carcinoma of the breast: case report and literature review. Am J Dermatopathol 38:698–703

    Article  PubMed  Google Scholar 

  • Kanitakis J (2007) Mammary and extramammary Paget’s disease. J Eur Acad Dermatol Venereol 21:581–590

    Article  CAS  PubMed  Google Scholar 

  • Kazakov DV, Suster S, LeBoit PE et al (2005) Mucinous carcinoma of the skin, primary, and secondary: clinicopathologic study of 63 cases with emphasis on the morphologic spectrum of primary cutaneous forms: homologies with mucinous lesions in the breast. Am J Surg Pathol 29:764–782

    Article  PubMed  Google Scholar 

  • Kazakov DV, Requena L, Kutzner H et al (2010) Morphologic diversity of syringocystadenocarcinoma papilliferum based on a clinicopathologic study of 6 cases and review of the literature. Am J Dermatopathol 32:340–347

    Article  PubMed  Google Scholar 

  • Lam C, Funaro D (2010) Extramammary Paget’s disease: summary of current knowledge. Dermatol Clin 28:807–826

    Article  CAS  PubMed  Google Scholar 

  • Molina-Ruiz AM, Llamas-Velasco M, Rütten A et al (2016) “Apocrine hidrocystoma and cystadenoma”-like tumor of the digits or toes: a potential diagnostic pitfall of digital papillary adenocarcinoma. Am J Surg Pathol 40:410–418

    Article  PubMed  Google Scholar 

  • Naylor E, Sarkar P, Perlis CS et al (2008) Primary cutaneous adenoid cystic carcinoma. J Am Acad Dermatol 58:636–641

    Article  PubMed  Google Scholar 

  • Nishie W, Sawamura D, Mayuzumi M et al (2004) Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands. J Cutan Pathol 31:561–564

    Article  PubMed  Google Scholar 

  • Ramakrishnan R, Chaudhry IH, Ramdial P et al (2013) Primary cutaneous adenoid cystic carcinoma: a clinicopathologic and immunohistochemical study of 27 cases. Am J Surg Pathol 37:1603–1611

    Article  PubMed  Google Scholar 

  • Requena L, VG Prieto VG, Requena C et al (2011) Primary signet-ring cell/histiocytoid carcinoma of the eyelid: a clinicopathologic study of 5 cases and review of the literature. Am J Surg Pathol 35:378–391

    Article  PubMed  Google Scholar 

  • Robson A, Greene J, Ansari N et al (2001) Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol 25:710–720

    Article  CAS  PubMed  Google Scholar 

  • Rütten A, Kutzner H, Mentzel T et al (2009) Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm. J Am Acad Dermatol 61:644–651

    Article  PubMed  Google Scholar 

  • Rütten A, Mentzel T, Requena L (2014) Endocrine mucin-producing sweat gland carcinoma. Three case reports with a brief review of the literature. Pathologist 35:462–466

    Article  Google Scholar 

  • Suchak R, Wang WL, Prieto VG et al (2009) Cutaneous digital papillary adenocarcinoma: a clinicopathologic study of 31 cases of a rare neoplasm with new observations. Am J Surg Pathol 36:1883–1891

    Article  Google Scholar 

  • Sugiyama A, Sugiura M, Piris A et al (2007) Apocrine cystadenoma and apocrine hidrocystoma: examination of 21 cases with emphasis on nomenclature according to proliferative features. J Cutan Pathol 34:912–917

    Article  PubMed  Google Scholar 

  • Sullica RL, Kao GF, Sullica VI et al (1994) Eccrine angiomatous hamartoma (nevus): immunohistochemical findings and review of the literature. J Cutan Pathol 21:71–75

    Article  Google Scholar 

  • Walker A, Mesinkovska NA, Emanuel PO et al (2016) Polymorphous sweat gland carcinoma: a report of two cases. J Cutan Pathol 43:594–601

    Article  PubMed  Google Scholar 

  • Zelger BG, Stelzmueller I, Dunst KM et al (2008) Solid apocrine carcinoma of the skin: report of a rare adnexal neoplasm mimicking lobular breast carcinoma. J Cutan Pathol 35:332–336

    Article  PubMed  Google Scholar 

Sebaceous Gland Tumors

  • Abbas O, Mahalingam M (2009) Cutaneous sebaceous neoplasms as markers of Muir-Torre syndrome: a diagnostic algorithm. J Cutan Pathol 36:613–619

    Article  PubMed  Google Scholar 

  • Dinneen AM, Mehregan DR (1996) Sebaceous epithelioma: a review of twenty-one cases. J Am Acad Dermatol 34:47–50

    Article  CAS  PubMed  Google Scholar 

  • Kasakov DM, Calonje E, Zelger B et al (2007) Sebaceous carcinoma arising in nevus sebaceous of Jadassohn: a clinicopathological study of five cases. Am J Dermatopathol 29:242–248

    Article  Google Scholar 

  • Kyllo RL, Brady KL, Hurst EA (2015) Sebaceous carcinoma: review of the literature. Dermatol Surg 41:1–15

    Article  CAS  PubMed  Google Scholar 

  • Ostler DA, Prieto JARJA et al (2010) Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. Mod Pathol 23:567–573

    Article  CAS  PubMed  Google Scholar 

  • Rütten A, Burgdorf W, Hügel H et al (1999) Cystic sebaceous tumors as marker lesions for the Muir-Torre syndrome. A histopathological and molecular genetic study. Am J Dermatopathol 21:405–413

    Article  PubMed  Google Scholar 

  • Salim A, Reece SM, Smith AG et al (2006) Sebaceous hyperplasia and skin cancer in patients undergoing renal transplant. J Am Acad Dermatol 55:878–881

    Article  PubMed  Google Scholar 

  • Shalin SC, Calonje E, Lazar AJ (2010) Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications. Histopathology 56:133–147

    Article  PubMed  PubMed Central  Google Scholar 

First Describer

  • Ancell H (1842) History of a remarkable case of tumours, developed on the head and face, accompanied with a similar disease in the abdomen. Med Chir Trans 25:227–246

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Boggio R (1975) Adenoid cystic carcinoma of scalp. Arch Dermatol 111:793–794

    Article  CAS  PubMed  Google Scholar 

  • Brooke HG (1892) Epithelioma adenoides cysticum. Br J Dermatol 4:269–286

    Google Scholar 

  • Brownstein MH, Shapiro L (1977) Desmoplastic trichoepithelioma. Cancer 40:2979–2986

    Article  CAS  PubMed  Google Scholar 

  • Elliot GT (1893) Adeno-cystoma intracanaliculare occurring in a nevus unius lateris. J Cutan Genitourin Dis 11:168–173

    Google Scholar 

  • Forbis RSM, Helwig EB (1961) Pilomatrixoma (calcifying epithelioma). Arch Dermatol 83:606–618

    Article  PubMed  Google Scholar 

  • Goldstein DJ, Barr RJ, Santa Cruz DJ (1982) Microcystic adnexal carcinoma: a distinct clinicopathologic entity. Cancer 50:566–572

    Article  CAS  PubMed  Google Scholar 

  • Gray HR, Helwig EB (1962) Trichofolliculoma. Arch Dermatol 86:619–625

    Article  Google Scholar 

  • Gromiko N (1927) Zur Kenntnis der bösartigen Umwandlung des verkalkten Hautepithelioms. Virchows Arch 205:103–116

    Article  Google Scholar 

  • Headington JT (1976) Tumors of the hair follicle. A review. Am J Pathol 85:479–514

    CAS  PubMed  PubMed Central  Google Scholar 

  • Headington JT, French AJ (1962) Primary neoplasms of the hair follicle. Arch Dermatol 86:430–431

    Article  CAS  PubMed  Google Scholar 

  • Helwig EB (1955) Inverted follicular keratosis. In: Seminar on the skin: neoplasms and dermatoses, American Society of Clinical Pathologists, International Congress on Clinical Pathology, Washington, vol 1954. American Society of Clinical Pathology, Washington, DC, p 38

    Google Scholar 

  • Hirsch P, Helwig EB (1961) Chondroid syringoma. Arch Dermatol 84:835–847

    Article  CAS  PubMed  Google Scholar 

  • Hyman AB, Harris H, Brownstein MH (1968) Eccrine angiomatous hamartoma. NY State J Med 68:2803–2809

    CAS  Google Scholar 

  • Jacquet L, Darier J (1887) Hydradenomes eruptifs. Ann Dermatol Syphiligr 8:317–323

    Google Scholar 

  • Johnson BL Jr, Helwig EB (1969) Eccrine acrospiroma. Cancer 23:641–657

    Article  PubMed  Google Scholar 

  • Jones DB (1955) Florid papillomatous of the nipple ducts. Cancer 8:4315–4319

    Article  Google Scholar 

  • Kao GF, Helwig EB, Graham JH (1987) Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histological, immunpathological, and ultrastructural observations. J Cutan Pathol 14:129–146

    Article  CAS  PubMed  Google Scholar 

  • Keasby LE, Hadley GG (1954) Clear-cell hidradenoma: report of three cases with widespread metastases. Cancer 7:934–952

    Article  Google Scholar 

  • Kersting DW (1963) Clear cell hidradenoma and hidradenocarcinoma. Arch Dermatol 87:323–333

    Article  CAS  PubMed  Google Scholar 

  • Kersting DW, Helwig EB (1956) Eccrine spiradenoma. Arch Dermatol 73:199–227

    Article  CAS  Google Scholar 

  • Kimura T, Miyazawa H, Aoyagi T et al (1991) Folliculosebaceous cystic hamartoma: a distinctive malformation of the skin. Am J Dermatopathol 13:213–220

    Article  CAS  PubMed  Google Scholar 

  • Kuo TT, Chan HL, Hsueh S (1987) Clear cell papulosis of the skin. Am J Surg Pathol 11:827–834

    Article  CAS  PubMed  Google Scholar 

  • Landry M, Winkelmann RK (1972) An unusual tubular apocrine adenoma. Arch Dermatol 105:869–879

    Article  CAS  PubMed  Google Scholar 

  • Lennox B, Pearse AG, Richards HG (1952) Mucin-secreting tumours of the skin with special reference to the so-called mixed-salivary tumour of the skin and its relation to hidradenoma. J Pathol Bacteriol 64:865–880

    Article  CAS  PubMed  Google Scholar 

  • Malherbe A, Chénantais J (1880) Note sur l’épithélioma calcifié des glandes sébacées. Bull Soc Anat Paris 5:169–176

    Google Scholar 

  • Mascaro JM (1963) Considérations on the tumult fibroépithéliales. Le syringofibroadénome eccrine. Ann Dermatol Syphiol 90:146–153

    Google Scholar 

  • Mehregan AH (1964) Apocrine cystadenoma; a clinicopathologic study with special reference to the pigmented variety. Arch Dermatol 90:274–279

    Article  CAS  PubMed  Google Scholar 

  • Mehregan AH, Brownstein MH (1978) Pilar sheath acanthoma. Arch Dermatol 114:1495–1497

    Article  CAS  PubMed  Google Scholar 

  • Mehregan AH, Butler JD (1961) A tumor of follicular infundibulum. Report of a case. Arch Dermatol 83:924–927

    Article  CAS  PubMed  Google Scholar 

  • Moll JA (1857) Bemerkungen über den Bau der Augenlider des Menschen. In: Arlt F, Donders FC, Graefe A (eds) Archiv für Ophthalmologie, vol 3. Peters, Berlin, pp 258–268

    Google Scholar 

  • Nikolowski W (1958) Tricho-Adenom (Organoides Follikel-Hamartoma). Arch Klin Exp Dermatol 207:34–45

    Article  CAS  PubMed  Google Scholar 

  • Paget J (1874) A disease of the mammary areola preceding cancer of the mammary gland. St Bartholomew’s Hosp Rep 10:87–89

    Google Scholar 

  • Pinkus H, Rogin JR, Goldman P (1956) Eccrine poroma. Tumors exhibiting features of the epidermal sweat duct unit. Arch Dermatol 74:511–521

    Article  Google Scholar 

  • Pinkus H, Coskey R, Burgess GH (1974) Trichodiscoma. A benign tumor related to hair disk. J Investig Dermatol 63:212–218

    Article  CAS  PubMed  Google Scholar 

  • Plewig G (1980) Sebaceous trichofolliculoma. J Cutan Pathol 7:394–403

    Article  CAS  PubMed  Google Scholar 

  • Requena L, Kiryu H, Ackerman AB (1998) Cribriform carcinoma. In: Requena L, Kiryu H, Ackerman AB (eds) Neoplasms with apocrine differentiation. Lippincott-Raven/Ardor Scribendi, Philadelphia, pp 879–905

    Google Scholar 

  • Robinson AR (1893) Hidrocystoma. J Cutan Gen Urin Dis 11:293–303

    Google Scholar 

  • Rosen Y, Kim B, Yermakov VA (1975) Eccrine sweat gland tumor of clear cell origin involving the eyelids. Cancer 36:1034–1041

    Article  CAS  PubMed  Google Scholar 

  • Rulon DB, Helwig EB (1977) Papillary eccrine adenoma. Arch Dermatol 113:596–598

    Article  CAS  PubMed  Google Scholar 

  • Smith JLS, Coburn JG (1956) Hidroacanthoma simplex. An assessment of a selected group of intraepidermal basal cell epitheliomas and their malignant homologues. Br J Dermatol 68:400–418

    Article  PubMed  Google Scholar 

  • Spiegler E (1899) Ueber Endotheliome der Haut. Arch Dermatol Syph 50:163–176

    Article  Google Scholar 

  • Swanson SA, Cooper PH, Mills SE et al (1988) Lymphoepithelioma-like carcinoma of the skin. Mod Pathol 1:359–365

    CAS  PubMed  Google Scholar 

  • Szymanski FJ (1957) Warty dyskeratoma; a benign cutaneous tumor resembling Darier’s disease microscopically. Arch Dermatol 75:567–572

    Article  CAS  Google Scholar 

  • Toker C (1970) Clear cells of the nipple epidermis. Cancer 25:601–610

    Article  CAS  PubMed  Google Scholar 

  • Troy JL, Ackerman AB (1984) Sebaceoma. A distinctive benign neoplasm of adnexal epithelium differentiating toward sebaceous cells. Am J Dermatopathol 6:7–13

    Article  CAS  PubMed  Google Scholar 

  • van der Putte SC (1991) Anogenital “sweat” glands. Histology and pathology of a gland that may mimic mammary glands. Am J Dermatopathol 13:557–567

    Article  PubMed  Google Scholar 

  • Werth R (1878) Zur Anatomie der Cysten der Vulva. Zentralbl Gynakol 22:513–516

    Google Scholar 

  • Werther L (1913) Syringadenoma papilliferum (naevus syringadenomatosus papilliferus). Arch Dermatol Syph 116:865–870

    Article  Google Scholar 

  • Winer LH (1954) The dilated pore, a trichoepithelioma. J Investig Dermatol 23:181–188

    Article  CAS  PubMed  Google Scholar 

  • Winkelmann RK, McLeod WA (1966) The dermal duct tumor. Arch Dermatol 94:50–55

    Article  CAS  PubMed  Google Scholar 

  • Zackheim HS, Pinkus H (1960) Perifollicular fibromas. Arch Dermatol 82:913–917

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Dermatopathology Lab, Friedrichshafen, Germany

    Arno Rütten

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  1. Arno Rütten
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Correspondence to Arno Rütten .

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Editors and Affiliations

  1. Department of Dermatology, University of Munich, Munich, Germany

    Gerd Plewig

  2. Department of Dermatology, University of Munich, Munich, Germany

    Lars French

  3. Department of Dermatology, University of Munich, Munich, Germany

    Thomas Ruzicka

  4. Department of Dermatology, Venerology and Allergology, Frankfurt University Hospital, Frankfurt, Germany

    Roland Kaufmann

  5. Clinic for Dermatology and Allergology, University of Marburg, Marburg, Germany

    Michael Hertl

Section Editor information

  1. Head of the Department of Dermatology, Venerology and Allergology, Frankfurt University Hospital, Frankfurt am Main, Germany

    Roland Kaufmann

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Rütten, A. (2020). Adnexal Tumors. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_103-1

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