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HIV/AIDS

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Braun-Falco´s Dermatology

Abstract

Infection with the human immunodeficiency virus (HIV) causes a progressive reduction of CD4+ lymphocytes and consecutive immunodeficiency; subsequent opportunistic infections and tumors ultimately lead to the acquired immune deficiency syndrome (AIDS). The diagnosis of AIDS was established in 1982 and the causative agent HIV was identified in 1983. In the 1980s and early 1990s, HIV infection led to severe disease courses and to death in the vast majority of the patients within a few months to years after diagnosis. With the development and introduction of new potent and tolerable antiretroviral drugs in the early twenty-first century, HIV infection lost almost all the horrors of the early years: today persons living with HIV (PLHIV) have a similar life expectancy to HIV-negative people, provided that HIV is diagnosed and treated early and the person is able to adhere to the treatment. However, we occasionally still see patients with fully developed AIDS, particularly in those diagnosed too late or in those who are not appropriately treated.

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References

  • Brenchley JM, Price DA, Schacker TW et al (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 12:1365–1371

    Article  CAS  Google Scholar 

  • Chilakaa VN, Konje JC (2021) HIV in pregnancy – an update. Eur J Obstet Gynecol Reprod Biol 256:484–491

    Article  Google Scholar 

  • Cohen MS, Shaw G, McMichael A, Haynes B (2011) Acute HIV-1 infection. N Engl J Med 364(20):1943–1954

    Article  CAS  Google Scholar 

  • Cohen MS, Council OD, Chen JS (2019) Sexually transmitted infections and HIV in the era of antiretroviral treatment and prevention: the biologic basis for epidemiologic synergy. J Int AIDS Soc 22(Suppl 6):e25355

    PubMed  PubMed Central  Google Scholar 

  • Doitsh G, Greene WC (2016) Dissecting how CD4 T cells are lost during HIV infection. Cell Host Microbe 19(3):280–291

    Article  CAS  Google Scholar 

  • Eisinger RW, Dieffenbach CW, Fauci AS (2019) HIV viral load and transmissibility of HIV infection: undetectable equals untransmittable. JAMA 321(5):451–452

    Article  Google Scholar 

  • Hengge UR, Ruzicka T, Tyring SK et al (2002a) Update on Kaposi’s sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapy. Lancet Infect Dis 2:281–292

    Article  Google Scholar 

  • Hengge UR, Ruzicka R, Tyring SK et al (2002b) Update on Kaposi’s sarcoma and other HHV8 associated diseases. Part 2: pathogenesis, Castleman’s disease, and pleural effusion lymphoma. Lancet Infect Dis 2:344–252

    Article  Google Scholar 

  • Jansen K, Steffen G, Potthoff A et al (2020) STI in times of PrEP: high prevalence of chlamydia, gonorrhea, and mycoplasma at different anatomic sites in men who have sex with men in Germany. BMC Infect Dis 20(1):110

    Article  CAS  Google Scholar 

  • Krown SE, Metroka C, Wernz JC (1989) Kaposi’s sarcoma in the acquired immune deficiency syndrome: proposal for uniform evaluation, response, and staging criteria. J Clin Oncol 7:1201–1207

    Google Scholar 

  • Kuo HH, Lichterfeld M (2018) Recent progress in understanding HIV reservoirs. Curr Opin HIV AIDS 13(2):137–142

    Article  CAS  Google Scholar 

  • Lebbe C, Garbe C, Stratigos AJ et al (2019) Diagnosis and treatment of Kaposi’s sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC). Eur J Cancer 114:117–127

    Article  CAS  Google Scholar 

  • Lundgren JD, Babiker AG, Gordin F et al (2015) Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med 373(9):795–807

    Article  CAS  Google Scholar 

  • Mallal SA, John M, Moore CB, James IR, McKinnon EJ (2000) Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection. AIDS 14(10):1309–1316

    Article  CAS  Google Scholar 

  • Marcus JL, Leyden WA, Alexeeff SE et al (2020) Comparison of overall and comorbidity-free life expectancy between insured adults with and without HIV infection, 2000–2016. JAMA Netw Open 3(6):e207954

    Article  Google Scholar 

  • Marzel A, Shilaih M, Yang WL et al (2016) HIV-1 transmission during recent infection and during treatment interruptions as major drivers of new infections in the Swiss HIV cohort study. Clin Infect Dis 62(1):115–122

    Article  Google Scholar 

  • Mollanazar NK, Qiu CC, Aldrich JL et al (2019) Use of dupilumab in HIV-positive patients: report of four cases. Br J Dermatol 181(6):1311–1312

    Article  CAS  Google Scholar 

  • Plachouri KM, Georgiou S (2019) Challenges in the treatment of psoriasis with biologics: vaccination, history of malignancy, human immunodeficiency virus (HIV) infection, and pediatric psoriasis. Int J Dermatol 58(9):1008–1013

    Article  Google Scholar 

  • Robb ML, Ananworanich J (2016) Lessons from acute HIV infection. Curr Opin HIV AIDS 11(6):555–560

    Article  CAS  Google Scholar 

  • Soriano V, Barreiro P, de Mendoza C (2020) Long-acting antiretroviral therapy. Nat Mater 19(8):826–827

    Article  CAS  Google Scholar 

  • The Late Presentation Working Groups in EuroSIDA and COHERE (2020) Estimating the burden of HIV late presentation and its attributable morbidity and mortality across Europe 2010–2016. BMC Infect Dis 20:728

    Article  Google Scholar 

  • Wolbers M, Babiker A, Sabin C et al (2010) Pretreatment CD4 cell slope and progression to AIDS or death in HIV-infected patients initiating antiretroviral therapy – the CASCADE collaboration: a collaboration of 23 cohort studies. PLoS Med 7(2):e1000239

    Article  Google Scholar 

  • Zheng J, Gui X, Cao Q et al (2015) A clinical study of acquired immunodeficiency syndrome associated penicillium Marneffei infection from a non-endemic area in China. PLoS One 10(6):e0130376

    Article  Google Scholar 

First Describer

  • Barre-Sinoussi F, Cherman JC, Rey F et al (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for AIDS. Science 220:868–861

    Article  CAS  Google Scholar 

  • Carr A, Samaras K, Chisholm DJ, Cooper DA (1998) A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. Lancet 351:1881–1883

    Article  CAS  Google Scholar 

  • Centers for Disease Control (1981) Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men – New York City and California. MMWR Morb Mortal Wkly Rep 30:305–308

    Google Scholar 

  • Friedman-Kien AE (1981) Disseminated Kaposi’s sarcoma syndrome in young homosexual men. J Am Acad Dermatol 5:468–471

    Article  CAS  Google Scholar 

  • Gallo RC, Sarin PS, Gelman EP et al (1983) Isolation of human T cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science 220:865–867

    Article  CAS  Google Scholar 

  • Greenspan D, Greenspan JS, Conant M et al (1984) Oral hairy leukoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. Lancet II:831–834

    Article  Google Scholar 

  • Rappersberger K, Gartner S, Schenk P et al (1988) Langerhans’ cells are an actual site of HIV-1 replication. Intervirology 29:185–194

    CAS  PubMed  Google Scholar 

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Correspondence to Armin Rieger .

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Rieger, A., Rappersberger, K. (2021). HIV/AIDS. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_21-1

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  • DOI: https://doi.org/10.1007/978-3-662-58713-3_21-1

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  • Print ISBN: 978-3-662-58713-3

  • Online ISBN: 978-3-662-58713-3

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