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Dermatomyositis and Other Autoimmune Disorders

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Braun-Falco´s Dermatology

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Abstract

Dermatomyositis is an idiopathic inflammatory myopathy characterized by different skin and/or muscle involvement and possible visceral organ manifestation. Dermatomyositis is associated with an increased risk of malignancy; therapeutic options include systemic immunosuppression with high-dose corticosteroids and adjuvant immunosuppressants. In refractory patients, high-dose intravenous immunoglobulins and rituximab are useful. A mixed connective tissue disease is a multi-organ disease with symptoms of other systemic autoimmune diseases, mostly systemic scleroderma and systemic lupus erythematosus with muscle and joint involvement. The detection of anti-U1RNP IgG autoantibodies is a diagnostic clue. In the context of rheumatoid arthritis, polymorphic, inflammatory nodular, vasculitic, and ulcerative skin lesions may appear on the skin. The detection of serum IgG autoantibodies against the transcription factor ΔNp63α is pathognomonic for the diagnosis of chronic ulcerative stomatitis.

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Author information

Authors and Affiliations

  1. Klinik III, Dermatologie und Allergologie, Bundeswehrzentralkrankenhaus, Koblenz, Germany

    Rüdiger Eming

  2. Klinik für Dermatologie und Allergologie, Philipps-Universität, Marburg, Germany

    Rüdiger Eming & Dario Didona

Authors
  1. Rüdiger Eming
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  2. Dario Didona
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Corresponding author

Correspondence to Rüdiger Eming .

Editor information

Editors and Affiliations

  1. Department of Dermatology, University of Munich, Munich, Germany

    Gerd Plewig

  2. Department of Dermatology, University of Munich, Munich, Germany

    Lars French

  3. Department of Dermatology, University of Munich, Munich, Germany

    Thomas Ruzicka

  4. Department of Dermatology, Venerology and Allergology, Frankfurt University Hospital, Frankfurt, Germany

    Roland Kaufmann

  5. Clinic for Dermatology and Allergology, University of Marburg, Marburg, Germany

    Michael Hertl

Section Editor information

  1. Centre for Skin Diseases, Marburg, Germany

    Michael Hertl

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Eming, R., Didona, D. (2021). Dermatomyositis and Other Autoimmune Disorders. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_55-1

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  • DOI: https://doi.org/10.1007/978-3-662-58713-3_55-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-58713-3

  • Online ISBN: 978-3-662-58713-3

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