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Disorders of Melanin Pigmentation

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Braun-Falco´s Dermatology

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Abstract

Melanin is the most important endogenous pigment of the skin. It is generated by special cells, the melanocytes, which originate from the neural crest. It is produced within special organelles, the melanosomes. By means of these organelles, the melanin is transferred to neighboring keratinocytes. This complex process of melanogenesis is genetically determined but also regulated by exogenous stimuli, especially UV radiation. Disturbances in melanin pigmentation have significant consequences for affected individuals. The spectrum of diseases caused by defective function of melanin pigmentation is very broad and ranges from circumscribed, generalized to universal congenital or acquired hypopigmentation and hyperpigmentation of the skin. As skin color by melanin determines the identity of an individual in the given socio-cultural context, disorders of pigmentation can lead to significant psychosocial consequences.

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Authors and Affiliations

  1. Department of Dermatology, University Hospital Münster, Münster, Germany

    Markus Böhm

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  1. Markus Böhm
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Correspondence to Markus Böhm .

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Editors and Affiliations

  1. Department of Dermatology, University of Munich, Munich, Germany

    Gerd Plewig

  2. Department of Dermatology, University of Munich, Munich, Germany

    Lars French

  3. Department of Dermatology, University of Munich, Munich, Germany

    Thomas Ruzicka

  4. Department of Dermatology, Venerology and Allergology, Frankfurt University Hospital, Frankfurt, Germany

    Roland Kaufmann

  5. Clinic for Dermatology and Allergology, University of Marburg, Marburg, Germany

    Michael Hertl

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  1. Department of Dermatology and Allergology, University of Munich, Munich, Germany

    Thomas Ruzicka

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Böhm, M. (2021). Disorders of Melanin Pigmentation. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_69-1

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