Skip to main content
SpringerLink
Log in

Other Skin Imaging Technologies

  • Living reference work entry
  • First Online:
Braun-Falco´s Dermatology

  • 47 Accesses

Abstract

Despite the simple visual accessibility of the skin, non-invasive diagnostic procedures in dermatology allow the recording in vivo of structural and functional changes of the skin to a great degree of accuracy. These methods can not only be used for diagnostics but also to investigate dynamic processes, quantify them and monitor their time course. In addition to ultrasound, which is dealt with in the chapter “Sonography of Skin and Lymph Nodes”, the methods of morphological imaging include confocal laser microscopy, optical coherence tomography, multiphoton tomography, and profilometry. Skin function parameters – such as barrier function, hydration status, color, pH value, sebum content, scaling, elasticity, oxygen supply, and blood circulation – can also be recorded and quantified non-invasively. In addition to the use of these methods in studies to quantify therapeutic effects, some techniques have found their way into routine diagnosis, for example in the early detection of skin cancer or as part of the assessment of occupational diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Astner S, González S, Gonzalez E (2006) Non-invasive evaluation of allergic and irritant contact dermatitis by in-vivo reflectance confocal microscopy. Dermatitis 17:182–191

    Article  Google Scholar 

  • Berardesca E, Elsner P, Wilhelm KP, Maibach HI (1995) Bioengineering of the skin: methods and instrumentation. CRC Press, Boca Raton

    Google Scholar 

  • Dimitrow E, Ziemer M, Koehler MJ et al (2006) Sensitivity and specificity of multiphoton laser tomography for in vivo and ex vivo diagnosis of malignant melanoma. J Invest Dermatol 129:1752–1758

    Article  Google Scholar 

  • Gerger A, Koller S, Weger W et al (2006) Sensitivity and specificity of confocal laser-scanning microscopy for in vivo diagnosis of malignant skin tumors. Cancer 107:193–200

    Article  Google Scholar 

  • Hanau A, Stücker M, Gambichler T et al (2003) Nichtinvasive Diagnostik von Hautfunktionen. Hautarzt 54:1211–1223

    Article  CAS  Google Scholar 

  • Hartmann D, Ruini C, Mathemeier L et al (2016) Identification of ex-vivo confocal scanning microscopic features and their histological correlates in human skin. J Biophotonics 9(4):376–387

    Article  Google Scholar 

  • Hartmann D, Krammer S, Bachmann MR et al (2018) Simple 3-criteria-based ex vivo confocal diagnosis of basal cell carcinoma. J Biophotonics 11(7):e201800062

    Article  Google Scholar 

  • Humbert P, Fanian F, Maibach HI, Agache A (eds) (2017) Agache’s measuring the skin. Springer, Berlin

    Google Scholar 

  • Köng K, Speicher M, Bückle R et al (2009) Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases. J Biophotonics 2:389–397

    Article  Google Scholar 

  • Longo C, Ragazzi M, Castagnetti F, Gardini S, Palmieri T, Lallas A, Moscarella E, Piana S, Pellacani G, Zalaudek I, Argenziano G (2013) Inserting ex vivo fluorescence confocal microscopy perioperatively in Mohs micrographic surgery expedites bedside assessment of excision margins in recurrent basal cell carcinoma. Dermatology 227:89–92

    Article  Google Scholar 

  • Nori S, Rius-Diaz F, Cuevas J et al (2004) Sensitivity and specificity of reflectance-mode confocal microscopy for in vivo diagnosis of basal cell carcinoma: a multicenter study. J Am Acad Dermatol 51:923–930

    Article  Google Scholar 

  • Pellacani G, Guitera P, Longo C et al (2007) The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J Invest Dermatol 127:2759–2765

    Article  CAS  Google Scholar 

  • Sattler EC, Kästle R, Welzel J (2013) Optical coherence tomography in dermatology. J Biomed Opt 18(6):061224

    Article  Google Scholar 

  • Themstrup L, Welzel J, Ciardo S, Kaestle R, Ulrich M, Holmes J, Whitehead R, Sattler EC, Kindermann N, Pellacani G, Jemec GB (2016) Validation of dynamic optical coherence tomography for non-invasive, in vivo microcirculation imaging of the skin. Microvasc Res 25(107):97–105

    Article  Google Scholar 

  • Ulrich M, Maltusch A, Rius-Diaz F et al (2008) Clinical applicability of in vivo reflectance, confocal microscopy for the diagnosis of actinic keratoses. Dermatol Surg 34:610–619

    CAS  PubMed  Google Scholar 

  • Ulrich M, von Braunmuehl T, Kurzen H et al (2015) The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study. Br J Dermatol 173:428–435

    Article  CAS  Google Scholar 

  • Ulrich M, Themstrup L, de Carvalho N et al (2016) Dynamic optical coherence tomography in dermatology. Dermatology 232:298–311

    Article  Google Scholar 

  • Ulrich M, Themstrup L, de Carvalho N et al (2018) Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines. J Eur Acad Dermatol Venereol 32(1):152–155

    Article  CAS  Google Scholar 

  • von Braunmühl T, Hartmann D, Tietze JK, Cekovic D, Kunte C, Ruzicka T, Berking C, Sattler EC (2016) Morphologic features of basal cell carcinoma using the en-face mode in frequency domain optical coherence tomography. J Eur Acad Dermatol Venereol 30:1919–1925

    Article  Google Scholar 

  • Welzel J, Schuh S (2017) Noninvasive diagnosis in dermatology. J Dtsch Dermatol Ges 15(10):999–1016

    PubMed  Google Scholar 

  • Welzel J, Kästle R, Sattler E (2016) Fluorescence (multiwave) Confocal Microscopy. Dermatol Clin 34(4):527–533

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, University Hospital Augsburg, Augsburg, Germany

    Julia Welzel

  2. Department of Dermatology, University Hospital, Munich, Germany

    Elke Sattler

Authors
  1. Julia Welzel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elke Sattler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Julia Welzel .

Editor information

Editors and Affiliations

  1. Department of Dermatology, University of Munich, Munich, Germany

    Gerd Plewig

  2. Department of Dermatology, University of Munich, Munich, Germany

    Lars French

  3. Department of Dermatology, University of Munich, Munich, Germany

    Thomas Ruzicka

  4. Department of Dermatology, Venerology and Allergology, Frankfurt University Hospital, Frankfurt, Germany

    Roland Kaufmann

  5. Clinic for Dermatology and Allergology, University of Marburg, Marburg, Germany

    Michael Hertl

Section Editor information

  1. Department of Dermatology, University of Munich, Munich, Germany

    Lars French

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer-Verlag GmbH Germany, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Welzel, J., Sattler, E. (2020). Other Skin Imaging Technologies. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_7-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-58713-3_7-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-58713-3

  • Online ISBN: 978-3-662-58713-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation