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Diseases of Fat

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Braun-Falco´s Dermatology

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Abstract

Fatty tissue is part of the connective tissue and is found almost everywhere in the body. Essentially, it serves as an energy store, offers protection against heat loss and performs mechanical tasks. Panniculitides are a broad group of inflammatory diseases of the subcutaneous fat with heterogeneous etiology. Patients often have uncharacteristically indurated erythematous nodules that may or may not be related to generalized symptoms. A diagnosis can often be achieved by histological analysis of a deep biopsy. By far the most common form of panniculitis is erythema nodosum, which is more common than all other forms of panniculitis taken together. Other panniculitides may develop consequent to infections, after physical injuries such as exposure to cold temperature, as part of different autoimmune diseases such as lupus erythematosus and rheumatoid arthritis, or as reactions to various drugs. Some other rare forms of panniculitides develop particularly in young children. This chapter also discusses the various forms and diseases accompanied by lipoatrophy and lipodystrophy.

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References

Overviews

  • Avram MM, Avram AS, James WD (2005a) Subcutaneous fat in normal and diseased states: 1. Introduction. J Am Acad Dermatol 53:663–670

    Article  PubMed  Google Scholar 

  • Avram AS, Avram MM, James WD (2005b) Subcutaneous fat in normal and diseased states: 2. Anatomy and physiology of white and brown adipose tissue. J Am Acad Dermatol 53:671–683

    Article  PubMed  Google Scholar 

  • Avram MM, Avram AS, James WD (2007) Subcutaneous fat in normal and diseased states: 3. Adipogenesis: from stem cell to fat cell. J Am Acad Dermatol 56:472–492

    Article  PubMed  Google Scholar 

  • Bastard JP, Maachi M, Lagathu C et al (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17:4–12

    CAS  PubMed  Google Scholar 

  • Requena L (2007) Normal subcutaneous fat, necrosis of adipocytes and classification of the panniculitides. Semin Cutan Med Surg 26:66–70

    Article  CAS  PubMed  Google Scholar 

  • Schäffler A, Müller-Ladner U, Schölmerich J, Büchler C (2006) Role of adipose tissue as an inflammatory organ in human disease. Endocr Rev 27:49–467

    Article  CAS  Google Scholar 

Panniculitis

  • Choy B, Chou S, Anforth R et al (2014) Panniculitis in patients treated with BRAF inhibitors: a case series. Am J Dermatopathol 36:493–497

    Article  PubMed  Google Scholar 

  • Cribier B, Caille A, Heid E et al (1998) Erythema nodosum and associated diseases. A study of 129 cases. Int J Dermatol 37:667–672

    Article  CAS  PubMed  Google Scholar 

  • De Fonclare AL, Khosrotehrani K, Aractingi S et al (2007) Erythema nodosum-like eruption as a manifestation of azathioprine hypersensitivity in patients with inflammatory bowel disease. Arch Dermatol 143:744–748

    Article  PubMed  Google Scholar 

  • Hasenöhrl K, Stein A, Wozel G, Meurer M (2006) Pankreopathische Pannikulitis bei neuroendokrinen Karzinom des Pankreas. Hautarzt 57:237–241

    Article  PubMed  Google Scholar 

  • Mahe E, Girszyn N, Hadj-Rabia S et al (2007) Subcutaneous fat necrosis of the newborn: a systematic evaluation of risk factors, clinical manifestations, complications and outcome of 16 children. Br J Dermatol 156:709–715

    Article  CAS  PubMed  Google Scholar 

  • Ortiz PG, Skov BG, Benfeldt E (2005) Alpha-1-antitrypsin deficiency-associated panniculitis: case report and review of treatment options. J Eur Acad Dermatol Venereol 19:487–490

    Article  CAS  PubMed  Google Scholar 

  • Pavicic T, Borelli C, Korting HC (2006) Cellulite – das größte Hautproblem des Gesunden? Eine Annäherung. J Dtsch Dermatol Ges 4:861–870

    Article  PubMed  Google Scholar 

  • Requena L, Sanchez Yus E (2001a) Panniculitis. I. Mostly septal panniculitis. J Am Acad Dermatol 45:163–183

    Article  CAS  PubMed  Google Scholar 

  • Requena L, Sanchez Yus E (2001b) Panniculitis. II. Mostly lobular panniculitis. J Am Acad Dermatol 45:325–361

    Article  CAS  PubMed  Google Scholar 

  • Requena L, Sanchez Yus E (2007) Erythema nodosum. Semin Cutan Med Surg 26:114–125

    Article  CAS  PubMed  Google Scholar 

  • Segura S, Pujol RM, Trindade F, Requena L (2008) Vasculitis in erythema induratum of Bazin: a histopathologic study of 101 biopsy specimens from 86 patients. J Am Acad Dermatol 59:839–851

    Article  PubMed  Google Scholar 

  • Sutra-Loubet C, Carlotti A, Guillemette J et al (2004) Neutrophilic panniculitis. J Am Acad Dermatol 50:280–285

    Article  PubMed  Google Scholar 

  • Torrelo A, Noguera-Morel L, Hernández-Martín A et al (2017) Recurrent lipoatrophic panniculitis of children. J Eur Acad Dermatol Venereol 31:536–543

    Article  CAS  PubMed  Google Scholar 

  • Tran TA, DuPree M, Carlson JA (1999) Neutrophilic lobular (pustular) panniculitis associated with rheumatoid arthritis: a case report and review of the literature. Am J Dermatopathol 21:247–252

    Article  CAS  PubMed  Google Scholar 

  • Walsh SN, Santa Cruz DJ (2010) Lipodermatosclerosis: a clinicopathological study of 25 cases. J Am Acad Dermatol 62:1005–1012

    Article  PubMed  Google Scholar 

  • White JW Jr, Winkelmann RK (1998) Weber-Christian panniculitis: a review of 30 cases with this diagnosis. J Am Acad Dermatol 39:56–62

    Article  PubMed  Google Scholar 

  • White WL, Wieselthier JS, Hitchcock MG (1996) Panniculitis: recent developments and observations. Semin Cutan Med Surg 15:278–299

    Article  CAS  PubMed  Google Scholar 

Lipoatrophy, Lipodystrophy, Lipomatosis, and Other Fatty Tissue Diseases

  • Eberting CL, Javor E, Gorden P et al (2005) Insulin resistance, acanthosis nigricans, and hypertriglyceridemia. J Am Acad Dermatol 52:341–344

    Article  PubMed  Google Scholar 

  • Garg A (2004) Acquired and inherited lipodystrophies. N Engl J Med 350:1220–1234

    Article  CAS  PubMed  Google Scholar 

  • Garg A, Misra A (2004) Lipodystrophies: rare disorders causing metabolic syndrome. Endocrinol Metab Clin N Am 33:305–331

    Article  CAS  Google Scholar 

  • Herane MI, Urbina F, Sudy E (2007) Lipoatrophia semicircularis: a compressive lipoatrophy consecutive to persistent mechanical pressure. J Dermatol 34:390–393

    Article  PubMed  Google Scholar 

  • Kosseifi S, Anaya E, Dronovalli G, Leicht S (2010) Dercum’s disease. Pain Med 11:1430–1434

    Article  PubMed  Google Scholar 

  • Langendoen SI, Habbema L, Nijsten TEC, Neumann HAM (2009) Lipoedema: from clinical presentation to therapy. A review of the literature. Br J Dermatol 161:980–986

    Article  CAS  PubMed  Google Scholar 

  • Warren AG, Janz BA, Borud LJ et al (2007) Evaluation and management of the fat leg syndrome. Plast Reconstr Surg 119:9e–15e

    Article  PubMed  CAS  Google Scholar 

First Describer

  • Allen EV, Hines EA (1940) Lipedema of the legs. Proc Mayo Clin 15:184–187

    Google Scholar 

  • Barraquer Roviralta L (1906) Histoire clinique d’un cas d’atrophie du tissue cellulo-adipeux. Barcelona

    Google Scholar 

  • Barroso I, Gurnell M, Crowley VE et al (1999) Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402:880–883

    Article  CAS  PubMed  Google Scholar 

  • Bazin E (1861) Leçons théoriques et cliniques sur la scrofule: considérée en elles-méme et dans ses rapports avec la syphilis, la dartre et l’arthritis, 2nd edn. Delahaye, Paris, pp 136–204

    Google Scholar 

  • Beacham BE, Cooper PH, Buchanan CS et al (1980) Equestrian cold panniculitis in women. Arch Dermatol 116:1025–1027

    Article  CAS  PubMed  Google Scholar 

  • Berardinelli W (1954) An undiagnosed endocrinometabolic syndrome: report of two cases. J Clin Endocrinol Metab 14:193–204

    Article  CAS  PubMed  Google Scholar 

  • Cause P (1875) Ein Fall von Sclerodermie (sogenannt Sclerodermia adultorum) bei einem Säugling. St Petersb Med Z 5:306–309

    Google Scholar 

  • Chiari H (1883) Über die sogenannte Fettnekrose. Prag Med Wochenschr 8:285–286

    Google Scholar 

  • Christian HA (1928) Relapsing febrile nodular nonsuppurative panniculitis. Arch Intern Med 42:338–351

    Article  Google Scholar 

  • Dercum FX (1888) A subcutaneous connective tissue dystrophy of the arm and the neck, associated with symptoms resembling myxedema. Univ Med Gaz Phila 1:140–150

    Google Scholar 

  • Dunnigan MG, Cochrane MA, Kelly A et al (1974) Familial lipoatrophic disease with dominant transmission. A new syndrome. Q J Med 43:33–48

    CAS  PubMed  Google Scholar 

  • Ferreira-Marques J (1953) Lipoatrophia anularis. Ein Fall einer bisher nicht beschriebenen Krankheit der Haut (des Panniculus adiposus). Arch Dermatol Syph 195:479–491

    Article  CAS  PubMed  Google Scholar 

  • Gschwandtner WR, Münzberger H (1974) Lipoatrophia semicircularis. Hautarzt 25:222–227

    Google Scholar 

  • Haxthausen H (1941) Adiponecrosis e frigore. Br J Dermatol 53:83–89

    Article  Google Scholar 

  • Holländer E (1909) Über einen Fall von fortschreitendem Schwund des Fettgewebes und seinen kosmetischen Ersatz durch Menschenfett. Münch Med Wochenschr 57:1794–1795

    Google Scholar 

  • Imamura S, Yamada M, Yamamoto K et al (1979) Lipodystrophia centrifugalis abdominalis infantilis. Dermatologist 30:360–364

    Google Scholar 

  • Köbberling J, Wilms B, Kattermann R et al (1975) Lipodystrophy of the extremities. A dominantly inherited syndrome associated with lipatrophic diabetes. Hum Genet 29:111–120

    Article  Google Scholar 

  • Launois PE, Bensaude R (1898) De l’adéno-lipomatose symétrique. Bull Soc Med Hop Paris 1:298–318

    Google Scholar 

  • Lawrence RD (1946) Lipodystrophy and hepatomegaly with diabetes, lipemia, and other metabolic disturbances. Lancet 1:724–731

    Article  PubMed  Google Scholar 

  • Madelung O (1888) Über den Fetthals (diffuses Lipom des Halses). Langenbecks Arch Klin Chir 37:106–130

    Google Scholar 

  • Makai E (1928) Über Lipogranulomatosis subcutanea. Klin Wochenschr 7:2343–2344

    Article  Google Scholar 

  • Mitchell SW (1885) Singular case of absence of adipose matter in upper half of the body. Am J Med Sci 90:105

    Article  Google Scholar 

  • Newton J, Wojnarowska FT (1988) Pustular panniculitis in rheumatoid arthritis. Br J Dermatol 119:97–98

    Article  Google Scholar 

  • Pfeiffer V (1892) Über einen Fall von herdweiser Atrophie des subkutanen Fettgewebes. Dtsch Arch Klin Med 50:438–449

    Google Scholar 

  • Rothmann M (1894) Über Entzündung und Atrophie des subkutanen Fettgewebes. Virchows Arch Pathol Anat 136:159–169

    Google Scholar 

  • Seip M (1959) Lipodystrophy and gigantism with associated endocrine manifestations: a new diencephalic syndrome? Acta Paediatr 48:555–574

    CAS  PubMed  Google Scholar 

  • Simons A (1911) Eine seltene Trophoneurose (“Lipodystrophia progressiva”). Z Gesamte Neurol Psychiatr 5:29–38

    Google Scholar 

  • Soltmann O (1899) Sclerema neonatorum. Zentralblatt KV, quoted as Sclerodem Soltmann (1901). Arch Dermatol Syph 56:295–296

    Google Scholar 

  • Underwood M (1784) A treatise on diseases of children. Mathews, London, p 76

    Google Scholar 

  • Von Hebra F (1860) Acute Exantheme und Hautkrankheiten. In: Virchow R (ed) Handbuch der speciellen Pathologie und Therapie, Bd3/Abteilung 1. Enke, Erlangen

    Google Scholar 

  • Warter J, Storck D, Grosshans E et al (1972) Syndrome de Weber-Christian associé à un déficit en alpha-1-antitrypsine; enquête familiale. Ann Med Internal (Paris) 123:877–882

    CAS  Google Scholar 

  • Weber FP (1925) A case of relapsing non-suppurative nodular panniculitis, showing phagocytosis of subcutaneous fat-cells by macrophages. Br J Dermatol 37:301–311

    Article  Google Scholar 

  • Young LW, Radebaugh JF, Rubin P et al (1971) New syndrome manifested by mandibular hypoplasia, acroosteolysis, stiff joints and cutaneous atrophy (mandibuloacral dysplasia) in two unrelated boys. Birth Defects Orig Artic Ser 7:291–297

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Dermatohistological Laboratory, Lübeck, Germany

    Christian Rose

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  1. Christian Rose
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Correspondence to Christian Rose .

Editor information

Editors and Affiliations

  1. Department of Dermatology, University of Munich, Munich, Germany

    Gerd Plewig

  2. Department of Dermatology, University of Munich, Munich, Germany

    Lars French

  3. Department of Dermatology, University of Munich, Munich, Germany

    Thomas Ruzicka

  4. Department of Dermatology, Venerology and Allergology, Frankfurt University Hospital, Frankfurt, Germany

    Roland Kaufmann

  5. Clinic for Dermatology and Allergology, University of Marburg, Marburg, Germany

    Michael Hertl

Section Editor information

  1. Department of Dermatology, University of Munich, Munich, Germany

    Lars French

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Rose, C. (2021). Diseases of Fat. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_77-1

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  • DOI: https://doi.org/10.1007/978-3-662-58713-3_77-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-58713-3

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