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Andrology

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Braun-Falco´s Dermatology

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Abstract

Andrology is an interdisciplinary medical specialty that primarily deals with the reproductive health of men. In addition to diagnosis and therapy in cases of an unfulfilled desire to have children (infertility), endocrine dysfunction of the testis (hypogonadism), including age-related aspects (puberty, senescence), sexual disorders (erectile dysfunction), and diseases of the male breast (gynecomastia) are important issues in andrology. Basic knowledge of andrological diseases and their sequelae should be available in every field of medicine. This becomes particularly evident when possible adverse effects of drugs, other exogenous noxae, or surgical procedures on male fertility have to be considered and options for the cryopreservation of germ cells (fertility protection) should be provided. Moreover, impairment of testicular and/or sexual functions can be a harbinger of systemic diseases or aggravated by comorbidities.

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References

  • Agarwal A, Mulgund A, Hamada A, Chyatte MR (2015) A unique view on male infertility around the globe. Reprod Biol Endocrinol 13:37

    Article  Google Scholar 

  • Auger J, Sermondade N, Eustache F (2016) Semen quality of 4480 young cancer and systemic disease patients: baseline data and clinical considerations. Basic Clin Androl 26:3

    Article  Google Scholar 

  • Barbonetti A, Martorella A, Minaldi E, D’Andrea S, Bardhi D, Castellini C, Francavilla F, Francavilla S (2019) Testicular Cancer in Infertile Men With and Without Testicular Microlithiasis: A Systematic Review and Meta-Analysis of Case-Control Studies. Front Endocrinol 10:164. https://doi.org/10.3389/fendo.2019.00164. PMID: 30949131

  • Barratt CLR, Björndahl L, De Jonge CJ, Lamb DJ, Osorio Martini F, McLachlan R, Oates RD, van der Poel S, St John B, Sigman M, Sokol R, Tournaye H (2017) The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities. Hum Reprod Update 23(6):660–680

    Article  Google Scholar 

  • Behre HM, Nieschlag E, Partsch J, Wieacker P, Simoni M (2010) Diseases of the hypothalamus and the pituitary gland. In: Nieschlag E, Behre HM, Nieschlag S (eds) Andrology – male reproductive health and dysfunction, 3rd edn. Springer, Berlin/Heidelberg/New York, pp 169–192

    Google Scholar 

  • Behre HM, Zitzmann M, Anderson RA, Handelsman DJ, Lestari SW, McLachlan RI, Meriggiola MC, Misro MM, Noe G, Wu FC, Festin MP, Habib NA, Vogelsong KM, Callahan MM, Linton KA, Colvard DS (2016) Efficacy and safety of an injectable combination hormonal contraceptive for men. J Clin Endocrinol Metab 101:4779–4788

    Google Scholar 

  • Bergmann M, Kliesch S (2010) Testicular biopsy and histology. In: Nieschlag E, Behre HM, Nieschlag S (eds) Andrology – male reproductive health and dysfunction, 3rd edn. Springer, Berlin/Heidelberg/New York, pp 155–167

    Google Scholar 

  • Bezold G, Politch JA, Kiviat NB et al (2007) Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertil Steril 87:1087–1097

    Article  Google Scholar 

  • Bhasin S, Brito JP, Cunningham GR et al (2018) Testosterone therapy in men with hypogonadism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 103:1715–1744

    Article  Google Scholar 

  • Björndahl L, Mortimer D, Barratt CLR, Castilla JA, Menkveld R, Kvist U, Alvarez JG, Haugen TB (2010) A practical guide to basic laboratory andrology. Cambridge University Press, Cambridge

    Book  Google Scholar 

  • Boehm U, Bouloux PM, Dattani MT, de Roux N, Dodé C, Dunkel L, Dwyer AA, Giacobini P, Hardelin JP, Juul A, Maghnie M, Pitteloud N, Prevot V, Raivio T, Tena-Sempere M, Quinton R, Young J (2015) European consensus statement on congenital hypogonadotropic hypogonadism – pathogenesis, diagnosis and treatment. Nat Rev Endocrinol 11(9):547–564

    Article  Google Scholar 

  • Boeri L, Capogrosso P, Ventimiglia E, Pederzoli F, Cazzaniga W, Chierigo F, Pozzi E, Clementi M, Viganò P, Montanari E, Montorsi F, Salonia A (2019) High-risk human papillomavirus in semen is associated with poor sperm progressive motility and a high sperm DNA fragmentation index in infertile men. Hum Reprod 34(2):209–217

    Article  Google Scholar 

  • Bonde JP (2006) Effects of lifestyle and toxicants. In: Schill W-B, Comhaire F, Hargreave TB (eds) Andrology for the clinician. Springer, Heidelberg, pp 348–357

    Chapter  Google Scholar 

  • Bonde JP, Flachs EM, Rimborg S, Glazer CH, Giwercman A, Ramlau-Hansen CH, Hougaard KS, Høyer BB, Hærvig KK, Petersen SB, Rylander L, Specht IO, Toft G, Bräuner EV (2016) The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis. Hum Reprod Update 23(1):104–125

    Article  Google Scholar 

  • Bonkat G, Pickard R, Bartoletti R, Cai T, Bruyere F, Geerlings SE, Köves B, Wagenlehner F (2019) EAU guidelines on urological infections. EAU Guidelines Office, Arnhem

    Google Scholar 

  • Bonomi M, Vezzoli V, Krausz C, Guizzardi F, Vezzani S, Simoni M, Bassi I, Duminuco P, Di Iorgi N, Giavoli C, Pizzocaro A, Russo G, Moro M, Fatti L, Ferlin A, Mazzanti L, Zatelli MC, Cannavò S, Isidori AM, Pincelli AI, Prodam F, Mancini A, Limone P, Tanda ML, Gaudino R, Salerno M, Francesca P, Maghnie M, Maggi M, Persani L, Italian Network on Central Hypogonadism (2018) Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH). Eur J Endocrinol 178(1):23–32

    Article  Google Scholar 

  • Brauner R, Neve M, Allali S, Trivin C, Lottmann H, Bashamboo A, McElreavey K (2011) Clinical, biological and genetic analysis of anorchia in 26 boys. PLoS One 6:e23292

    Article  Google Scholar 

  • Braunstein GD (2007) Clinical practice. Gynecomastia. N Engl J Med 357:1229–1237

    Article  Google Scholar 

  • Büchter D, Behre HM, Kliesch S, Nieschlag E (1998) Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. Eur J Endocrinol 139:298–303

    Article  Google Scholar 

  • Bundesärztekammer (2018) Richtlinie zur Entnahme und Übertragung von menschlichen Keimzellen im Rahmen der assistierten Reproduktion. Dtsch Ärztebl [11.05.2018]. https://doi.org/10.3238/arztebl.2018.Rili_assReproduktion_2018

  • Chansel-Debordeaux L, Dandieu S, Bechoua S, Jimenez C (2015) Reproductive outcome in globozoospermic men: update and prospects. Andrology 3(6):1022–1034

    Article  Google Scholar 

  • Chemes HE, Rawe VY (2003) Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile emn. Hum Reprod Update 9: 405–428

    Google Scholar 

  • Choy JT, Brannigan RE (2013) The determination of reproductive safety in men during and after cancer treatment. Fertil Steril 100(5):1187–1191

    Article  Google Scholar 

  • Cissen M, Wely MV, Scholten I, Mansell S, Bruin JP, Mol BW, Braat D, Repping S, Hamer G (2016) Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: a systematic review and meta-analysis. PLoS One 11(11):e0165125. https://doi.org/10.1371/journal.pone.0165125

    Article  Google Scholar 

  • Colpi GM, Francavilla S, Haidl G, Link K, Behre HM, Goulis DG, Krausz C, Giwercman A (2018) European academy of andrology guideline management of oligo-astheno-teratozoospermia. Andrology 6(4):513–524

    Article  Google Scholar 

  • Comhaire FH, Dhooge W, Zalata A, Depuydt C, Mahmoud A, Schoonjans F (1998) Östrogenartig wirkende Umweltnoxen. Fertilität 13:S6–S8

    Google Scholar 

  • Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, Haugen TB, Kruger T, Wang C, Mbizvo MT, Vogelsong KM (2010) World Health Organization reference values for human semen characteristics. Hum Reprod Update 16:231–245

    Article  Google Scholar 

  • Corona G, Pizzocaro A, Lanfranco F, Garolla A, Pelliccione F, Vignozzi L, Ferlin A, Foresta C, Jannini EA, Maggi M, Lenzi A, Pasquali D, Francavilla S; Klinefelter ItaliaN Group (KING) (2017) Sperm recovery and ICSI outcomes in Klinefelter syndrome: a systematic review and meta-analysis. Hum Reprod Update 23(3):265–275. https://doi.org/10.1093/humupd/dmx008

  • Corona G, Minhas S, Giwercman A, Bettocchi C, Dinkelman-Smit M, Dohle G, Fusco F, Kadioglou A, Kliesch S, Kopa Z, Krausz C, Pelliccione F, Pizzocaro A, Rassweiler J, Verze P, Vignozzi L, Weidner W, Maggi M, Sofikitis N (2019) Sperm recovery and ICSI outcomes in men with non-obstructive azoospermia: a systematic review and meta-analysis. Hum Reprod Update 25(6):733–757

    Article  Google Scholar 

  • Corona G, Goulis DG, Huhtaniemi I, Zitzmann M, Toppari J, Forti G, Vanderschueren D, Wu FC (2020) European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: endorsing organization: European Society of Endocrinology. Andrology 8(5):970–987. https://doi.org/10.1111/andr.12770. Epub 2020 Mar 20. PMID: 32026626

    Article  Google Scholar 

  • Coutton C, Escoffier J, Martinez G et al (2015) Teratozoospermia: spotlight on the main genetic actors in the human. Hum Reprod Update 21(4):455–485

    Article  Google Scholar 

  • Dabaja AA, Schlegel PN (2013) Microdissection testicular sperm extraction: an update. Asian J Androl 15:35–39

    Article  Google Scholar 

  • Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Blomberg Jensen M, Matulevicius V, Zilaitiene B, Olesen IA, Perheentupa A, Punab M, Salzbrunn A, Toppari J, Virtanen HE, Juul A, Skakkebæk NE, Jørgensen N (2016) Varicocele is associated with impaired semen quality and reproductive hormone levels: a study of 7035 healthy Young men from six European countries. Eur Urol 70(6):1019–1029

    Article  Google Scholar 

  • De Geyter C, De Geyter M, Behre HM (2010) Assisted reproduction. In: Nieschlag E, Behre HM, Nieschlag S (eds) Andrology – male reproductive health and dysfunction, 3rd edn. Springer, Berlin/Heidelberg/New York, pp 469–504

    Google Scholar 

  • De Kretser DM (1997) Male infertility. Lancet 349:787–790

    Article  Google Scholar 

  • Deutsches IVF-Register (2019) DIR-Annual 2018. J Reproduktionsmed Endokrinol 16(6):272–311

    Google Scholar 

  • Dohle GR, Arver S, Bettocchi C, Jones TH, Kliesch S (2019) EAU guidelines on male hypogonadism. EAU Guidelines Office, Arnhem

    Google Scholar 

  • Du Plessis SS, Kashou AH, Benjamin DJ, Yadav SP, Agarwal A (2011) Proteomics: a subcellular look at spermatozoa. Reprod Biol Endocrinol 9:36

    Article  Google Scholar 

  • Eisenberg ML, Li S, Cullen MR, Baker LC (2016) Increased risk of incident chronic medical conditions in infertile men: analysis of United States claims data. Fertil Steril 105:629–636

    Article  Google Scholar 

  • Epelboin S, Dulioust E, Epelboin L, Benachi A, Merlet F, Patrat C (2017) Zika virus and reproduction: facts, questions and current management. Hum Reprod Update 23(6):629–645

    Article  Google Scholar 

  • FDA Drug Safety Communication (2018) FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. https://www.fda.gov/Drugs/DrugSafety/ucm511530.htm

  • Fentiman IS, Fourquet A, Hortobagyi GN (2006) Male breast cancer. Lancet 367:595–604

    Article  Google Scholar 

  • Fijak M, Pilatz A, Hedger MP, Nicolas N, Bhushan S, Michel V, Tung KSK, Schuppe HC, Meinhardt A (2018) Infectious, inflammatory and ‘autoimmune’ male factor infertility: how do rodent models inform clinical practice? Hum Reprod Update 24(4):416–441

    Article  Google Scholar 

  • Foresta C, Noventa M, De Toni L, Gizzo S, Garolla A (2015) HPV-DNA sperm infection and infertility: from a systematic literature review to a possible clinical management proposal. Andrology 3(2):163–173

    Article  Google Scholar 

  • Francavilla F, Barbonetti A (2017) Male autoimmune infertility. In: Krause W, Naz RK (eds) Immune infertility. Impact of immune reactions on human fertility. Springer, Cham (Switzerland) pp 187–196

    Google Scholar 

  • Fretz PC, Sandlow JI (2002) Varicocele: current concepts in pathophysiology, diagnosis, and treatment. Urol Clin North Am 29:921–937

    Article  Google Scholar 

  • Garolla A, Pizzol D, Bertoldo A, De Toni L, Barzon L, Foresta C (2013a) Association, prevalence, and clearance of human papillomavirus and antisperm antibodies in infected semen samples from infertile patients. Fertil Steril 99(1):125–131

    Article  Google Scholar 

  • Garolla A, Torino M, Sartini B, Cosci I, Patassini C, Carraro U, Foresta C (2013b) Seminal and molecular evidence that sauna exposure affects human spermatogenesis. Hum Reprod 28:877–885

    Article  Google Scholar 

  • Gillam MP, Molitch ME, Lombardi G, Colao A (2006) Advances in the treatment of prolactinomas. Endocr Rev 27:485–534

    Article  Google Scholar 

  • Gravholt CH, Chang S, Wallentin M, Fedder J, Moore P, Skakkebæk A (2018) Klinefelter syndrome: integrating genetics, neuropsychology, and endocrinology. Endocr Rev 39(4):389–423. https://doi.org/10.1210/er.2017-00212. PMID: 29438472

    Article  Google Scholar 

  • Grunewald S, Jank A (2015) New systemic agents in dermatology with respect to fertility, pregnancy, and lactation. J Dtsch Dermatol Ges 13(4):277–289

    Google Scholar 

  • Grunewald S, Reinhardt M, Blumenauer V, Said TM, Agarwal A, Abu Hmeidan F, Glander HJ, Paasch U (2009) Increased sperm chromatin decondensation in selected nonapoptotic spermatozoa of patients with male infertility. Fertil Steril 92:572–577

    Article  Google Scholar 

  • Hadziselimovic F (2017) On the descent of the epididymo-testicular unit, cryptorchidism, and prevention of infertility. Basic Clin Androl 27:21. https://doi.org/10.1186/s12610-017-0065-8

    Article  Google Scholar 

  • Haidl G (2002) Management strategies for male factor infertility. Drugs 62:1741–1753

    Article  Google Scholar 

  • Haidl G, Schuppe H-C (2006) Cytomorphological semen analysis. In: Schill W-B, Comhaire F, Hargreave TB (eds) Andrology for the clinician. Springer, Heidelberg, pp 555–560

    Google Scholar 

  • Haidl G, Haidl F, Allam JP, Schuppe HC (2019) Therapeutic options in male genital tract inflammation. Andrologia 51(3):e13207. https://doi.org/10.1111/and.13207. Epub 2018 Nov 26. PMID: 30474250

    Article  Google Scholar 

  • Hamilton JA, Cissen M, Brandes M, Smeenk JM, de Bruin JP, Kremer JA, Nelen WL, Hamilton CJ (2015) Total motile sperm count: a better indicator for the severity of male factor infertility than the WHO sperm classification system. Hum Reprod 30(5):1110–1121

    Article  Google Scholar 

  • Hanson BM, Eisenberg ML, Hotaling JM (2018) Male infertility: a biomarker of individual and familial cancer risk. Fertil Steril 109(1):6–19

    Article  Google Scholar 

  • Hassan MAM, Killick SR (2004) Negative lifestyle is associated with a significant reduction in fecundity. Fertil Steril 81:384–392

    Article  Google Scholar 

  • Heksch R, Kamboj M, Anglin K, Obrynba K (2017) Review of Prader-Willi syndrome: the endocrine approach. Transl Pediatr 6(4):274–285

    Article  Google Scholar 

  • Jakab A, Sakkas D, Delpiano E, Cayli S, Kovanci E, Ward D, Revelli A, Huszar G (2005) Intracytoplasmic sperm injection: a novel selection method for sperm with normal frequency of chromosomal aneuploidies. Fertil Steril 84:1665–1673

    Article  Google Scholar 

  • Jones TH, Channer KS (2012) Testosterone, obesity, diabetes and the metabolic syndrome. In: Nieschlag E, Behre HM (eds) Testosterone – action, deficiency, substitution, 4th edn, Cambridge University Press, Cambridge/New York, pp 235–250

    Google Scholar 

  • Jung A, Schuppe HC (2007) Influence of genital heat stress on semen quality in humans. Andrologia 39:203–215

    Article  Google Scholar 

  • Jungwirth A, Diemer T, Kopa Z, Krausz C, Mihas S, Tournaye H (2019) EAU guidelines on male infertility. EAU Guidelines Office, Arnhem

    Google Scholar 

  • Jurewicz M, Gilbert BR (2016) Imaging and angiography in male factor infertility. Fertil Steril 105(6):1432–1442

    Article  Google Scholar 

  • Kamischke A, Nieschlag E (2002) Update on medical treatment of ejaculatory disorders. Int J Androl 25:333–344

    Article  Google Scholar 

  • Kanakasabapathy MK, Sadasivam M, Singh A, Preston C, Thirumalaraju P, Venkataraman M, Bormann CL, Draz MS, Petrozza JC, Shafiee H (2017) An automated smartphone-based diagnostic assay for point-of-care semen analysis. Sci Transl Med 9(382):pii: eaai7863

    Article  Google Scholar 

  • Kanakis GA, Nieschlag E (2018) Klinefelter syndrome: more than hypogonadism. Metabolism 86:135–144

    Article  Google Scholar 

  • Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N (2019) EAA clinical practice guidelines-gynecomastia evaluation and management. Andrology 7(6):778–793

    Article  Google Scholar 

  • Kesari KK, Agarwal A, Henkel R (2018) Radiations and male fertility. Reprod Biol Endocrinol 16(1):118. https://doi.org/10.1186/s12958-018-0431-1. Published 2018 Dec 9

    Article  Google Scholar 

  • Khan HN, Blamey RW (2003) Endocrine treatment of physiological gynaecomastia. BMJ 327:301–302

    Article  Google Scholar 

  • Köhn FM (2004) Diagnostik und Therapie des Hypogonadismus bei erwachsenen Männern. Hautarzt 55:877–897

    Google Scholar 

  • Köhn FM, Beier KM (2015) Sexualmedizin in der klinischen Praxis. MMW Fortschr Med 157(1):38–41

    Article  Google Scholar 

  • Köhn F-M, Schuppe HC (2017) Fertilitätserhalt beim Mann. In: Fehm T et al (eds) Fertilitätserhalt in der Gynäko-Onkologie. De Gruyter, Berlin, pp 47–56

    Google Scholar 

  • Kopeika J, Thornhill A, Khalaf Y (2015) The effect of cryopreservation on the genome of gametes and embryos: principles of cryobiology and critical appraisal of the evidence. Hum Reprod Update 21:209–227

    Article  Google Scholar 

  • Krause WKH (2008) Drugs compromising male sexual health. Springer, Berlin/Heidelberg/New York/Tokyo

    Google Scholar 

  • Krausz C, Riera-Escamilla A (2018) Genetics of male infertility. Nat Rev Urol 15(6):369–384. https://doi.org/10.1038/s41585-018-0003-3

    Article  Google Scholar 

  • Krausz C, Hoefsloot L, Simoni M, Tüttelmann F, European Academy of Andrology; European Molecular Genetics Quality Network (2014) EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: state-of-the-art 2013. Andrology 2(1):5–19

    Article  Google Scholar 

  • Kroese AC, de Lange NM, Collins J et al (2014) Surgery or embolization for varicoceles in subfertile men: summary of a Cochrane review. Fertil Steril 102:1553–1555

    Article  Google Scholar 

  • Lanfranco F, Kamischke A, Zitzmann M et al (2004) Klinefelter‘s syndrome. Lancet 364:273–283

    Article  Google Scholar 

  • Latif T, Kold Jensen T, Mehlsen J, Holmboe SA, Brinth L, Pors K, Skouby SO, Jørgensen N, Lindahl-Jacobsen R (2017) Semen quality as a predictor of subsequent morbidity: a Danish cohort study of 4,712 men with long-term follow-up. Am J Epidemiol 186(8):910–917

    Article  Google Scholar 

  • Laurentino S, Borgmann J, Gromoll J (2016) On the origin of sperm epigenetic heterogeneity. Reproduction 151(5):R71–R78

    Article  Google Scholar 

  • Le Tortorec A, Matusali G, Mahé D, Aubry F, Mazaud-Guittot S, Houzet L, Dejucq-Rainsford N (2020) From Ancient to Emerging Infections: The Odyssey of Viruses in the Male Genital Tract. Physiol Rev 100(3):1349–1414. https://doi.org/10.1152/physrev.00021.2019

  • Lotti F, Maggi M (2015) Ultrasound of the male genital tract in relation to male reproductive health. Hum Reprod Update 21(1):56–83

    Article  Google Scholar 

  • Luttmer R, Dijkstra MG, Snijders PJ, Hompes PG, Pronk DT, Hubeek I, Berkhof J, Heideman DA, Meijer CJ (2016) Presence of human papillomavirus in semen in relation to semen quality. Hum Reprod 31(2):280–286

    Google Scholar 

  • Mallidis C, Cooper TG, Hellenkemper B et al (2012) Ten years‘ experience with an external quality control program for semen analysis. Fertil Steril 98:611–616

    Article  Google Scholar 

  • Mascarenhas MN, Flaxman SR, Boerma T et al (2012) National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med 9:e1001356

    Article  Google Scholar 

  • McLachlan RI, Rajpert-De Meyts EK et al (2007) Histological evaluation of the human testis – approaches to optimizing the clinical value of the assessment: mini review. Hum Reprod 22:2–16

    Article  Google Scholar 

  • Mehta A, Sigman M (2015) Management of the dry ejaculate: a systematic review of aspermia and retrograde ejaculation. Fertil Steril 104(5):1074–1081

    Article  Google Scholar 

  • Molitch ME (2017) Diagnosis and treatment of pituitary adenomas: a review. JAMA 317(5):516–524

    Article  Google Scholar 

  • Muratori M, Tamburrino L, Marchiani S, Cambi M, Olivito B, Azzari C, Forti G, Baldi E (2015) Investigation on the origin of sperm DNA fragmentation: role of apoptosis, immaturity and oxidative stress. Mol Med 21:109–122

    Article  Google Scholar 

  • Ni K, Spiess AN, Schuppe HC, Steger K (2016) The impact of sperm protamine deficiency and sperm DNA damage on human male fertility: a systematic review and meta-analysis. Andrology 4(5):789–799. https://doi.org/10.1111/andr.12216

    Article  Google Scholar 

  • Nieschlag E (2010) Scope and goals of andrology. In: Nieschlag E, Behre HM, Nieschlag S (eds) Andrology – male reproductive health and dysfunction, 3rd edn. Springer, Berlin/Heidelberg/New York, pp 1–9

    Google Scholar 

  • Nieschlag E (2015) Current topics in testosterone replacement of hypogonadal men. Best Pract Res Clin Endocrinol Metab 29(1):77–90. https://doi.org/10.1016/j.beem.2014.09.008. Epub 2014 Oct 2. PMID: 25617174

    Article  Google Scholar 

  • Nieschlag E, Behre HM (eds) (2012) Testosterone – action, deficiency, substitution, 4th edn. Cambridge University Press, Cambridge/New York

    Google Scholar 

  • Nieschlag E, Vorona E (2015) Mechanisms in endocrinology: medical consequences of doping with anabolic androgenic steroids: effects on reproductive functions. Eur J Endocrinol 173:R47–58

    Google Scholar 

  • Nieschlag E, Pock T, Hellenkemper B (2017) External quality control of semen analysis reveals low compliance with WHO guidelines. J Reproduktionsmed Endokrinol 14(6):306–310

    Google Scholar 

  • Nordhoff V (2015) How to select immotile but viable spermatozoa on the day of intracytoplasmic sperm injection? An embryologist’s view. Andrology 3(2):156–162

    Article  Google Scholar 

  • Olesen IA, Andersson AM, Aksglaede L, Skakkebaek NE, Rajpert-de Meyts E, Joergensen N, Juul A (2017) Clinical, genetic, biochemical, and testicular biopsy findings among 1,213 men evaluated for infertility. Fertil Steril 107(1):74–82.e7

    Article  Google Scholar 

  • Patat O, Pagin A, Siegfried A, Mitchell V, Chassaing N, Faguer S, Monteil L, Gaston V, Bujan L, Courtade-Saïdi M, Marcelli F, Lalau G, Rigot JM, Mieusset R, Bieth E (2016) Truncating mutations in the adhesion G protein-coupled receptor G2 gene ADGRG2 cause an X-linked congenital bilateral absence of vas deferens. Am J Hum Genet 99(2):437–442

    Article  Google Scholar 

  • Patel B, Parets S, Akana M, Kellogg G, Jansen M, Chang C, Cai Y, Fox R, Niknazar M, Shraga R, Hunter C, Pollock A, Wisotzkey R, Jaremko M, Bisignano A, Puig O (2018) Comprehensive genetic testing for female and male infertility using next-generation sequencing. J Assist Reprod Genet 35(8):1489–1496

    Article  Google Scholar 

  • Picton HM, Wyns C, Anderson RA et al (2015) ESHRE task force on fertility preservation in severe diseases a European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys. Hum Reprod 30:2463–2475

    Article  Google Scholar 

  • Practice Committee of the American Society for Reproductive Medicine (2018) Smoking and infertility: a committee opinion. Fertil Steril 110(4):611–618

    Article  Google Scholar 

  • Raivio T, Falardeau J, Dwyer A, Quinton R, Hayes FJ, Hughes VA, Cole LW, Pearce SH, Lee H, Boepple P, Crowley WF Jr, Pitteloud N (2007) Reversal of idiopathic hypogonadotropic hypogonadism. N Engl J Med 357(9):863–873. https://doi.org/10.1056/NEJMoa066494. PMID: 17761590

    Article  Google Scholar 

  • Rajpert-De Meyts E, McGlynn KA, Okamoto K, Jewett MA, Bokemeyer C (2016) Testicular germ cell tumours. Lancet 387(10029):1762–1774

    Article  Google Scholar 

  • Reifsnyder JE, Ramasamy R, Husseini J, Schlegel PN (2012) Role of optimizing testosterone before microdissection testicular sperm extraction in men with nonobstructive azoospermia. J Urol 188(2):532–536

    Article  Google Scholar 

  • Rohayem J, Fricke R, Czeloth K, Mallidis C, Wistuba J, Krallmann C, Zitzmann M, Kliesch S (2015a) Age and markers of Leydig cell function, but not of Sertoli cell function predict the success of sperm retrieval in adolescents and adults with Klinefelter’s syndrome. Andrology 3(5):868–875

    Article  Google Scholar 

  • Rohayem J, Nieschlag E, Kliesch S, Zitzmann M (2015b) Inhibin B, AMH, but not INSL3, IGF1 or DHEAS support differentiation between constitutional delay of growth and puberty and hypogonadotropic hypogonadism. Andrology 3(5):882–887

    Article  Google Scholar 

  • Rohayem J, Nieschlag E, Zitzmann M, Kliesch S (2016a) Testicular function during puberty and young adulthood in patients with Klinefelter's syndrome with and without spermatozoa in seminal fluid. Andrology 4(6):1178–1186

    Article  Google Scholar 

  • Rohayem J, Sinthofen N, Nieschlag E, Kliesch S, Zitzmann M (2016b) Causes of hypogonadotropic hypogonadism predict response to gonadotropin substitution in adults. Andrology 4(1):87–94

    Article  Google Scholar 

  • Rohayem J et al (2017) Delayed treatment of undescended testes may promote hypogonadism and infertility. Endocrine 55(3):914–924

    Article  Google Scholar 

  • Rowe PJ, Comhaire FH, Hargreave TB et al (2000) WHO manual for the standardized investigation, diagnosis and management of the infertile male. Cambridge University Press, Cambridge

    Google Scholar 

  • Rusz A, Pilatz A, Wagenlehner F, Linn T, Diemer T, Schuppe HC, Lohmeyer J, Hossain H, Weidner W (2012) Influence of urogenital infections and inflammation on semen quality and male fertility. World J Urol 30:23–30

    Article  Google Scholar 

  • Said TM, Land JA (2011) Effects of advanced selection methods on sperm quality and ART outcome: a systematic review. Hum Reprod Update 17:719–733

    Article  Google Scholar 

  • Sakkas D, Ramalingam M, Garrido N, Barratt CL (2015) Sperm selection in natural conception: what can we learn from mother nature to improve assisted reproduction outcomes? Hum Reprod Update 21:711–726

    Article  Google Scholar 

  • Salas-Huetos A, Bulló M, Salas-Salvadó J (2017) Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update 23:371–389

    Article  Google Scholar 

  • Salonia A et al (2020) European Association of Urology (EAU) guidelines on male sexual and reproductive health. http://uroweb.org/guidelines. Accessed 2020.

  • Salzbrunn A, Benson DM, Holstein AF et al (1996) A new concept for the extraction of testicular spermatozoa as a tool for assisted fertilization (ICSI). Hum Reprod 11:752–755

    Article  Google Scholar 

  • Samplaski MK, Lo K, Grober E, Jarvi K (2013) Finasteride use in the male infertility population: effects on semen and hormone parameters. Fertil Steril 100(6):1542–6

    Google Scholar 

  • Santi D, Spaggiari G, Simoni M (2018) Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management – meta-analyses. Reprod Biomed Online 37(3):315–326

    Article  Google Scholar 

  • Sartorius GA, Handelsman D (2010) Testicular dysfunction in systemic diseases. In: Nieschlag E, Behre HM, Nieschlag S (eds) Andrology – male reproductive health and dysfunction, 3rd edn. Springer, Berlin/Heidelberg/New York, pp 339–364

    Google Scholar 

  • Schagdarsurengin U, Steger K (2016) Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health. Nat Rev Urol 13(10):584–595

    Article  Google Scholar 

  • Schanz S, Schreiber G, Zitzmann M et al (2017) S1-Leitlinie: Gynäkomastie im Erwachsenenalter. J Dtsch Dermatol Ges 15:465–472

    Google Scholar 

  • Schuppe H-C, Köhn F-M (2018) Einfluss von Lebensstil und Umweltfaktoren auf die reproduktive Gesundheit des Mannes. Hautarzt 69(12):996–1005

    Article  Google Scholar 

  • Schuppe H-C et al (2016a) Endokrine Krankheitsbilder. In: Michel MS, Janetschek G, Wirth M, Sulser T (Hrsg) Die Urologie. Springer, Berlin, S 1603–1612

    Google Scholar 

  • Schuppe H-C, Köhn F-M, Pilatz A, Diemer T, Bergmann M, Weidner W (2016b) Andrologische Diagnostik bei Fertilitätsstörungen. In: Michel MS, Janetschek G, Wirth M, Sulser T (eds) Die Urologie. Springer, Berlin/Heidelberg, pp 1565–1575

    Chapter  Google Scholar 

  • Schuppe H-C, Pilatz A, Hossain H, Diemer T, Wagenlehner F, Weidner W (2017) Urogenital infection as a risk factor for male infertility. Dtsch Ärztebl Int 114:339–346

    Google Scholar 

  • Schwarzer JU, Schwarz M (2012) Significance of CFTR gene mutations in patients with congenital aplasia of vas deferens with special regard to renal aplasia. Andrologia 44(5):305–307

    Article  Google Scholar 

  • Semans JH (1956) Premature ejaculation: a new approach. South Med J 49:353–358

    Article  Google Scholar 

  • Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, Perrin J (2017) The impact of drugs on male fertility: a review. Andrology 5(4):640–663

    Article  Google Scholar 

  • Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, Van Wely M, Cao J, Martini AC, Eskandar M, Chavarro JE, Koloszar S, Twigt JM, Ramlau-Hansen CH, Borges E Jr, Lotti F, Steegers-Theunissen RP, Zorn B, Polotsky AJ, La Vignera S, Eskenazi B, Tremellen K, Magnusdottir EV, Fejes I, Hercberg S, Lévy R, Czernichow S (2013) BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update 19:221–231

    Article  Google Scholar 

  • Showell MG, Mackenzie-Proctor R, Brown J et al (2014) Antioxidants for male subfertility. Cochrane Database Syst Rev 12:CD007411

    Google Scholar 

  • Sijstermans K, Hack WW, Meijer RW et al (2008) The frequency of undescended testis from birth to adulthood: a review. Int J Androl 31:1–11

    Google Scholar 

  • Simon L, Zini A, Dyachenko A, Ciampi A, Carrell DT (2017) A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome. Asian J Androl 19(1):80–90

    Article  Google Scholar 

  • Simoni M, Tüttelmann F, Gromoll J, Nieschlag E (2008) Clinical consequences of microdeletions of the Y chromosome: the extended Münster experience. Reprod Biomed Online 16:289–303

    Article  Google Scholar 

  • Skakkebaek NE, Rajpert-De Meyts E, Main KM (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16(5):972–978. https://doi.org/10.1093/humrep/16.5.972. PMID: 11331648

    Article  Google Scholar 

  • Stukenborg JB, Alves-Lopes JP, Kurek M, Albalushi H, Reda A, Keros V, Töhönen V, Bjarnason R, Romerius P, Sundin M, Norén Nyström U, Langenskiöld C, Vogt H, Henningsohn L, Mitchell RT, Söder O, Petersen C, Jahnukainen K (2018) Spermatogonial quantity in human prepubertal testicular tissue collected for fertility preservation prior to potentially sterilizing therapy. Hum Reprod 33(9):1677–1683

    Article  Google Scholar 

  • Tian Y, Zhou LQ (2021) Evaluating the impact of COVID-19 on male reproduction. Reproduction 161(2):R37–R44. https://doi.org/10.1530/REP-20-0523

  • Tosti E, Ménézo Y (2016) Gamete activation: basic knowledge and clinical applications. Hum Reprod Update 22(4):420–439

    Article  Google Scholar 

  • Toth B et al (2019) Diagnostik und Therapie vor einer assistierten reproduktionsmedizinischen Behandlung (ART). S2k-Leitlinie, AWMF-Register Nr. 015/ 085, 02/2019. https://www.awmf.org/leitlinien/detail/ll/015-085.html

  • Tournaye H, Dohle GR, Barratt CL (2014) Fertility preservation in men with cancer. Lancet 384(9950):1295–1301

    Article  Google Scholar 

  • Tournaye H, Krausz C, Oates RD (2017a) Novel concepts in the aetiology of male reproductive impairment. Lancet Diabetes Endocrinol 5:544–553

    Article  Google Scholar 

  • Tournaye H, Krausz C, Oates RD (2017b) Concepts in diagnosis and therapy for male reproductive impairment. Lancet Diabetes Endocrinol 5:554–564

    Article  Google Scholar 

  • Trottmann M, Becker AJ, Stadler T et al (2007) Semen quality in men with malignant diseases before and after therapy and the role of cryopreservation. Eur Urol 52:355–367

    Article  Google Scholar 

  • Tüttelmann F, Gromoll J (2010) Novel genetic aspects of Klinefelter’s syndrome. Mol Hum Reprod 16(6):386–395

    Article  Google Scholar 

  • Tüttelmann F, Nieschlag E (2010) Classification of andrological disorders. In: Nieschlag E, Behre HM, Nieschlag S (eds) Andrology – male reproductive health and dysfunction, 3rd edn. Springer, Berlin/Heidelberg/New York, pp 87–92

    Google Scholar 

  • Tüttelmann F, Werny F, Cooper TG, Kliesch S, Simoni M, Nieschlag E (2011) Clinical experience with azoospermia: aetiology and chances for spermatozoa detection upon biopsy. Int J Androl 34:291–298

    Article  Google Scholar 

  • Tüttelmann F, Ruckert C, Röpke A (2018) Disorders of spermatogenesis. Medizinische Genetik 30(1):12–20

    Article  Google Scholar 

  • van Casteren NJ, Looijenga LH, Dohle GR (2009) Testicular microlithiasis and carcinoma in situ overview and proposed clinical guideline. Int J Androl 32:279–287

    Article  Google Scholar 

  • van der Steeg JW, Steures P, Eijkemans MJ, Habbema JDF, Hompes PG, Kremer JA, van der Leeuw-Harmsen L, Bossuyt PM, Repping S, Silber SJ, Mol BW, van der Veen F, Collaborative Effort for Clinical Evaluation in Reproductive Medicine Study Group (2011) Role of semen analysis in subfertile couples. Fertil Steril 95:1013–1019

    Article  Google Scholar 

  • Virtanen HE, Toppari J (2015) Cryptorchidism and fertility. Endocrinol Metab Clin N Am 44(4):751–760

    Article  Google Scholar 

  • Vorona E, Zitzmann M, Gromoll J, Schüring AN, Nieschlag E (2007) Clinical, endocrinological, and epigenetic features of the 46,XX male syndrome, compared with 47,XXY Klinefelter patients. J Clin Endocrinol Metab 92(9):3458–3465

    Article  Google Scholar 

  • Wagenlehner F, Pilatz A, Linn T et al (2013) Prostatitis and andrological implications. Minerva Urol Nefrol 65(2):117–123

    Google Scholar 

  • Waldinger MD, Schweitzer DH (2008) The use of old and recent DSM definitions of premature ejaculation in observational studies: a contribution to the present debate for a new classification of PE in the DSM-V. J Sex Med 5(5):1079–1087. https://doi.org/10.1111/j.1743-6109.2008.00789.x. Epub 2008 Mar 4. PMID: 18331260

    Article  Google Scholar 

  • Walsh TJ, Croughan MS, Schembri M, Chan JM, Turek PJ (2009) Increased risk of testicular germ cell cancer among infertile men. Arch Intern Med 169:351–356

    Article  Google Scholar 

  • Warne DW, Decosterd G, Okada H, Yano Y, Koide N, Howles CM (2009) A combined analysis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombinant human follicle-stimulating hormone and human chorionic gonadotropin. Fertil Steril 92:594–604

    Article  Google Scholar 

  • Weidner WHG, Schuppe H-C, Pilatz A et al (2014) Sperm cells for artificial reproduction and germ cell transplantation. Eur Urol Suppl 13:83–88

    Article  Google Scholar 

  • World Health Organization (1999) WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4. Aufl. Cambridge University Press, Cambridge

    Google Scholar 

  • World Health Organization (2010) WHO laboratory manual for the examination and processing of human semen, 5th edn. WHO Press, Geneva

    Google Scholar 

  • Wu FC, Tajar A, Beynon JM et al (2010) Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 363:123–135

    Article  Google Scholar 

  • Wu QY, Li N, Li WW, Li TF, Zhang C, Cui YX, Xia XY, Zhai JS (2014) Clinical, molecular and cytogenetic analysis of 46, XX testicular disorder of sex development with SRY-positive. BMC Urol 14:70

    Article  Google Scholar 

  • Yatsenko AN, Georgiadis AP, Röpke A et al (2015) X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men. N Engl J Med 372:2097–2107

    Article  Google Scholar 

  • Yu J, Chen Z, Ni Y, Li Z (2012) CFTR mutations in men with congenital bilateral absence of the vas deferens (CBAVD): a systemic review and meta-analysis. Hum Reprod 27(1):25–35

    Article  Google Scholar 

  • Zini A, Lefebvre J, Kornitzer G et al (2011) Anti-sperm antibody levels are not related to fertilization or pregnancy rates after IVF or IVF/ICSI. J Reprod Immunol 88(1):80–84

    Article  Google Scholar 

  • Zitzmann M (2009) Pharmacogenetics of testosterone replacement therapy. Pharmacogenomics 10:1341–1349

    Article  Google Scholar 

  • Zitzmann M, Faber S, Nieschlag E (2006) Association of specific symptoms and metabolic risks with serum testosterone in older men. J Clin Endocrinol Metab 91:4335–4343

    Article  Google Scholar 

First Describer

  • Afzelius BA, Eliasson R, Johnsen O, Lindholmer C (1975) Lack of dynein arms in immotile human spermatozoa. J Cell Biol 66:225–232

    Article  Google Scholar 

  • Baccetti B, Burrini AG, Maver A et al (1979) “9+0” immotile spermatozoa in an infertile man. Andrology 11:437–443

    Article  Google Scholar 

  • Del Castillo EB, Trabucco A, de la Balze A (1947) Syndrome produced by absence of the germinal epithelium without impairment of the Sertoli or Leydig cells. J Clin Endocrinol Metab 7:493–502

    Article  Google Scholar 

  • Escalier D (1983) Human spermatozoa with large heads and multiple flagella: a quantitative ultrastructural study of 6 cases. Biol Cell 48:65–74

    Article  Google Scholar 

  • Kallmann FJ, Schoenfeld WA, Barrera SE (1944) The genetic aspects of primary eunuchoidism. Am J Ment Defic 48:203–206

    Google Scholar 

  • Kartagener MI (1933) Mitteilung: Bronchiektasien bei situs viscerum inversus. Beitr Klin Tuberk 83:489–501

    Article  Google Scholar 

  • Klinefelter HF Jr, Reifenstein EC Jr, Albright F (1942) Syndromes characterized by gynecomastia, aspermatogenesis without A-leydigism, and increased excretion of follicle-stimulating hormone. J Clin Endocrinol 2:615–627

    Article  Google Scholar 

  • Prader A, Labhart A, Willi H (1956) Ein Syndrom von Adipositas, Kleinwuchs, Kryptorchismus und Oligophrenie nach myoatonieartigem Zustand im Neugeborenenalter. Schweiz Med Wochenschr 86:1260–1261

    Google Scholar 

  • Schirren CG, Holstein AF, Schirren C (1971) Über die Morphogenese rundköpfiger Spermatozoen des Menschen. Andrologie 3:117–125

    Google Scholar 

  • Tanner JM (1962) Growth at adolescence, 2nd edn. Blackwell, Oxford

    Google Scholar 

  • Tiepolo L, Zuffardi O (1976) Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum Genet 34:119–124

    Article  Google Scholar 

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Authors and Affiliations

  1. Andrology Unit, Department of Urology, Pediatric Urology and Andrology, Universitätsklinikum Giessen und Marburg – Standort Giessen; Justus-Liebig-University, Giessen, Germany

    Hans-Christian Schuppe

  2. Andrologicum München, Munich, Germany

    Frank-Michael Köhn

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  1. Hans-Christian Schuppe
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Correspondence to Hans-Christian Schuppe .

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Editors and Affiliations

  1. Department of Dermatology, University of Munich, Munich, Germany

    Gerd Plewig

  2. Department of Dermatology, University of Munich, Munich, Germany

    Lars French

  3. Department of Dermatology, University of Munich, Munich, Germany

    Thomas Ruzicka

  4. Department of Dermatology, Venerology and Allergology, Frankfurt University Hospital, Frankfurt, Germany

    Roland Kaufmann

  5. Clinic for Dermatology and Allergology, University of Marburg, Marburg, Germany

    Michael Hertl

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  1. Department of Dermatology and Allergology, University of Munich, Munich, Germany

    Lars E. French

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Schuppe, HC., Köhn, FM. (2021). Andrology. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_83-1

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