Abstract
Numerous disorders of mineral metabolism can be accompanied by skin changes. Iron deficiency with possible angular cheilitis and glossitis, diffuse hair loss, or (rarely) typical nail changes (onychoschisis or koilonychia) is an example. In iron overload (hemochromatosis) a distinction is made between primary and secondary forms. The yellowish-brownish discoloration of the skin (bronze diabetes) often precedes the changes in internal organs. Zinc deficiency results in seborrheic skin lesions, which can be congenital, as in acrodermatitis enteropathica. Copper deficiency leads to brittle, bristly hair (Menkes syndrome) or, in Wilson’s disease, to the Kayser-Fleischer corneal ring in addition to rather inconspicuous skin changes. Disturbances in the metabolism of sulfur, iodine, and selenium or intoxications with lead or mercury can also cause skin changes, as well as other symptoms.
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Szeimies, RM., Dirschka, T. (2020). Diseases of Mineral Metabolism. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_96-1
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