Skip to main content

Cancer-Associated Retinopathy

  • Living reference work entry
  • First Online:
The Uveitis Atlas
  • 309 Accesses

Abstract

Cancer-associated retinopathy (CAR) is a subgroup of autoimmune retinopathy caused by paraneoplastic anti-retinal antibodies. It is characterized by bilateral, rapidly progressive, painless vision loss, often out of proportion to the clinical exam. Visual field testing typically shows scotomas and/or constriction. Electroretinography (ERG) often shows decreased amplitudes or delayed peak-times but may be within normal range or near-normal early in the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Suggested Reading

  • Abazari A, Allam SS, Adamus G, Ghazi NG. Optical coherence tomography findings in autoimmune retinopathy. Am J Ophthalmol. 2012;153:750–6, 756.e1.

    Article  PubMed  PubMed Central  Google Scholar 

  • Adamus G. Autoantibody targets and their cancer relationship in the pathogenicity of paraneoplastic retinopathy. Autoimmun Rev. 2009;8:410–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Braithwaite T, Holder GE, Lee RWJ, Plant GT, Tufail A. Diagnostic features of the autoimmune retinopathies. Autoimmun Rev. 2014;13:534–8.

    Article  CAS  PubMed  Google Scholar 

  • Chan JW. Paraneoplastic retinopathies and optic neuropathies. Surv Ophthalmol. 2003;48:12–38.

    Article  PubMed  Google Scholar 

  • Comlekoglu DU, Thompson IA, Sen HN. Autoimmune retinopathy. Curr Opin Ophthalmol. 2013;24:598–605.

    Article  PubMed  Google Scholar 

  • Grange L, Dalal M, Nussenblatt RB, Sen HN. Autoimmune retinopathy. Am J Ophthalmol. 2014;157:266–72.e1.

    Article  CAS  PubMed  Google Scholar 

  • Lima LH, et al. Hyperautofluorescent ring in autoimmune retinopathy. Retina. 2012;32:1385–94.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pepple KL, Cusick M, Jaffe GJ, Mruthyunjaya P. SD-OCT and autofluorescence characteristics of autoimmune retinopathy. Br J Ophthalmol. 2013;97:139–44.

    Article  PubMed  Google Scholar 

  • Shildkrot Y, Sobrin L, Gragoudas ES. Cancer-associated retinopathy: update on pathogenesis and therapy. Semin Ophthalmol. 2011;26:321–8.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to H. Nida Sen .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer India (outside the USA)

About this entry

Cite this entry

Wei, M.M., Armbrust, K.R., Jeffrey, B.G., Sen, H.N. (2016). Cancer-Associated Retinopathy. In: Gupta, V., Nguyen, Q., LeHoang, P., Herbort Jr., C. (eds) The Uveitis Atlas. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2506-5_102-1

Download citation

  • DOI: https://doi.org/10.1007/978-81-322-2506-5_102-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New Delhi

  • Online ISBN: 978-81-322-2506-5

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics