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Idiopathic Retinal Vasculitis, Aneurysms and Neuroretinitis (IRVAN)

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Abstract

Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis (IRVAN) is a rare retinal vascular inflammatory disorder affecting young adults. The hallmark of this condition is the presence of aneurysmal dilatations of the retinal arterioles at or near the optic disc giving them a “knotted” appearance allowing the diagnosis to be made clinically in most cases. The exact etiology of the condition is unknown as yet. The clinical course of IRVAN can vary from spontaneous resolution to progressive ishcaemia, neovascularization, neovascular glaucoma and even blindness.

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  • Abu El-Asrar AM, Jestaneiah S, Al-Serhani AM. Regression of aneurysmal dilatations in a case of idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) associated with allergic fungal sinusitis. Eye (Lond). 2004;18:197–9.

    Article  CAS  Google Scholar 

  • Akesbi J, Brousseaud FX, Adam R, Rodallec T, Nordmann JP. Intravitreal bevacizumab (Avastin) in idiopathic retinitis, vasculitis, aneurysms and neuroretinitis. Acta Ophthalmol. 2010;88:e40–1.

    Article  PubMed  Google Scholar 

  • Basha M, Brown GC, Palombaro G, Shields CL, Shields JA. Management of IRVAN syndrome with observation. Ophthalmic Surg Lasers Imaging Retina. 2014;45:e18–22.

    PubMed  Google Scholar 

  • Chang TS, Aylward GW, Davis JL, Mieler WF, Oliver GL, Maberly AL, et al. Idiopathic retinal vasculitis, aneurysms, and neuro-retinitis: the Retinal Vasculitis Study Group. Ophthalmology. 1995;102:1089–97.

    Article  CAS  PubMed  Google Scholar 

  • Cheema RA, Al-Askar E, Cheema HR. Infliximab therapy for idiopathic retinal vasculitis, aneurysm, and neuroretinitis syndrome. J Ocul Pharmacol Ther. 2011;27:407–10.

    Article  CAS  PubMed  Google Scholar 

  • Empeslidis T, Banerjee S, Vardarinos A, Konstas AG. Dexamethasone intravitreal implant for idiopathic retinal vasculitis, aneurysms, and neuroretinitis. Eur J Ophthalmol. 2013;23:757–60.

    Article  PubMed  Google Scholar 

  • Gharbiya M, Pantaleoni FB, Accorinti M, et al. Indocyanine green angiography in a case of idiopathic retinal vasculitis, aneurysms and neuroretinitis. Eye (Lond). 2000;14:655–9.

    Article  Google Scholar 

  • Hammond MD, Ward TP, Katz B, Subramanian PS. Elevated intracranial pressure associated with idiopathic retinal vasculitis, aneurysms and neuroretinitis syndrome. J Neuroophthalmol. 2004;24:221–4.

    Article  PubMed  Google Scholar 

  • Karagiannis D, Soumplis V, Georgalas I, Kandarakis A. Ranibizumab for idiopathic retinal vasculitis, aneurysms, and neuroretinitis: favorable results. Eur J Ophthalmol. 2010;20:792–4.

    PubMed  Google Scholar 

  • Karel I, Peleska M, Divisova G. Fluorescence angiography in retinal vasculitis in children’s uveitis. Ophthalmologica. 1973;166:251–64.

    Article  CAS  PubMed  Google Scholar 

  • Kincaid J, Schatz H. Bilateral retinal arteritis with multiple aneurysmal dilatations. Retina. 1983;3:171–8.

    Article  CAS  PubMed  Google Scholar 

  • Malan P, Ciurana AJ, Boudet C. Arterite retinienne bilaterale avec dilatations aneurysm ales multiples. J Fr Ophtalmol. 1986;9:23–8.

    CAS  PubMed  Google Scholar 

  • Owens SL, Gregor ZJ. Vanishing retinal arterial aneurysms: a case report. Br J Ophthalmol. 1992;76:637–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pichi F, Ciardella AP. Imaging in the diagnosis and management of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN). Int Ophthalmol Clin. 2012;52:275–82.

    Article  PubMed  Google Scholar 

  • Rouvas A, Nikita E, Markomichelakis N, Theodossiadis P, Pharmakakis N. Idiopathic retinal vasculitis, arteriolar macroaneurysms and neuroretinitis: clinical course and treatment. J Ophthalmic Inflamm Infect. 2013;3:21. doi:10.1186/1869-5760-3-21.

    Article  PubMed  PubMed Central  Google Scholar 

  • Russell SR, Folk JC. Branch retinal artery occlusion after dye yellow photocoagulation of an arterial macroaneurysm. Am J Ophthalmol. 1987;104:186–7.

    Article  CAS  PubMed  Google Scholar 

  • Saatci AO, Ayhan Z, Takes O, Yaman A, Bajin FM. Single bilateral dexamethasone implant in addition to panretinal photocoagulation and oral azathioprine treatment in IRVAN syndrome. Case Rep Ophthalmol. 2015;6:56–62.

    Article  PubMed  PubMed Central  Google Scholar 

  • Samuel MA, Equi RA, Chang TS, Mieler W, Jampol LM, Hay D, et al. Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN): new observations and a proposed staging system. Ophthalmology. 2007;114:1526–9.

    Article  PubMed  Google Scholar 

  • Sashihara H, Hayashi H, Oshima K. Regression of retinal arterial aneurysms in a case of idiopathic retinal vasculitis, aneurysms, and neuroretinitis. Retina. 1999;19:250–1.

    Article  CAS  PubMed  Google Scholar 

  • Sawhney GK, Payne JF, Ray R, Mehta S, Bergstrom CS, Yeh S. Combination anti-VEGF and corticosteroid therapy for idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome. Ophthalmic Surg Lasers Imaging Retina. 2013;44:599–602.

    Article  PubMed  Google Scholar 

  • Soheilian M, Nourinia R, Tavallali A, Peyman GA. Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (irvan) syndrome associated with positive perinuclear antineutrophil cytoplasmic antibody (P-ANCA). Retin Cases Brief Rep. 2010;4:198–201.

    Article  PubMed  Google Scholar 

  • Yeshurun I, Recillas-Gispert C, Navarro-Lopez P, Arellanes-Garcia L, Cervantes-Coste G. Extensive dynamics in location, shape, and size of aneurysms in a patient with idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome. Idiopathic retinal vasculitis, aneurysms, and neuroretinitis. Am J Ophthalmol. 2003;135:118–20.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Advanced Eye Centre, Post Graduate Institute of Medical Education and Research (PGIMER), 160012, Chandigarh, India

    M. R. Dogra & Deeksha Katoch

Authors
  1. M. R. Dogra
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  2. Deeksha Katoch
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Correspondence to M. R. Dogra .

Editor information

Editors and Affiliations

  1. Advanced Eye Center, PGIMER, Chandigarh, India

    Vishali Gupta

  2. Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska, USA

    Quan Dong Nguyen

  3. Department of Ophthalmology, Pitié-Salpêtrière University, Paris, France

    Phuc LeHoang

  4. University of Lausanne, Lausanne, Switzerland

    Carl P Herbort Jr.

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© 2016 Springer (India) Pvt. Ltd.

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Dogra, M.R., Katoch, D. (2016). Idiopathic Retinal Vasculitis, Aneurysms and Neuroretinitis (IRVAN). In: Gupta, V., Nguyen, Q., LeHoang, P., Herbort Jr., C. (eds) The Uveitis Atlas. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2506-5_131-1

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  • DOI: https://doi.org/10.1007/978-81-322-2506-5_131-1

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  • Publisher Name: Springer, New Delhi

  • Online ISBN: 978-81-322-2506-5

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