Skip to main content

Fungal Endophthalmitis

  • Living reference work entry
  • First Online:
  • 198 Accesses

Abstract

Fungal endophthalmitis is defined as the intraocular presence of fungi, involving the vitreous and/or the aqueous humors, accompanied by an inflammatory reaction. The epidemiology of fungal endophthalmitis is highly influenced by the environment, the climate, and people living conditions. Endogenous invasion of the eye usually begins with the localization of microorganisms carried by the bloodstream at the level of the choroid or, the retina (fungal chorioretinitis). Exogenous fungal endophthalmitis is usually post-surgical/post traumatic, and can be characterized by a delayed onset and a less aggressive behavior as compared to bacterial.

The treatment of fungal endophthalmitis is based on a combination of systemic and intravitreal antimycotic drugs usually associated with pars plana vitrectomy.

The visual outcome is variable ad depends on a correct management of the disease, on the lesions location, the causative agent and the stage at presentation.

This is a preview of subscription content, log in via an institution.

Suggested Reading

  • Aguilar GL, Blumenkrantz MS, Egbert PR, McCulley JP. Candida endophthalmitis after intravenous drug abuse. Arch Ophthalmol. 1979;97(1):96–100.

    Article  CAS  PubMed  Google Scholar 

  • Beebe WE, Kirkland C, Price J. A subretinal neovascular membrane as a complication of endogenous Candida endophthalmitis. Ann Ophthalmol. 1987;19(6):207–9.

    CAS  PubMed  Google Scholar 

  • Brooks RG. Prospective study of Candida endophthalmitis in hospitalized patients with candidemia. Arch Intern Med. 1989;149(10):2226–8.

    Article  CAS  PubMed  Google Scholar 

  • Callanan D, Scott IU, Murray TG, Oxford KW, Bowman CB, Flynn Jr HW. Early onset endophthalmitis caused by Aspergillus species following cataract surgery. Am J Ophthalmol. 2006;142:509–11.

    Article  PubMed  Google Scholar 

  • Chakrabarti A, Shivaprakash MR, Singh R, Tarai B, George VK, Fomda BA, Gupta A. Fungal endophthalmitis: fourteen years’ experience from a center in India. Retina. 2008;28(10):1400–7.

    Article  PubMed  Google Scholar 

  • Cho M, Khanifar AA, Chan RV. Spectral-domain optical coherence tomography of endogenous fungal endophthalmitis. Retin Cases Brief Rep. 2011;5(2):136–40. doi:10.1097/ICB.0b013e3181cc2146.

    Article  PubMed  Google Scholar 

  • Essman TF, Flynn Jr HW, Smiddy WE, Brod RD, Murray TG, Davis JL, Rubsamen PE. Treatment outcomes in a 10-year study of endogenous fungal endophthalmitis. Ophthalmic Surg Lasers. 1997;28(3):185–94.

    CAS  PubMed  Google Scholar 

  • Henderson DK, Edwards Jr JE, Ishida K, Guze LB. Experimental hematogenous Candida endophthalmitis: diagnostic approaches. Infect Immun. 1979;23(3):858–62.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jaeger EE, Carroll NM, Choudhury S, Dunlop AA, Towler HM, Matheson MM, Adamson P, Okhravi N, Lightman S. Rapid detection and identification of Candida, Aspergillus, and Fusarium species in ocular samples using nested PCR. J Clin Microbiol. 2000;38(8):2902–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Rao NA, Hidayat AA. Endogenous mycotic endophthalmitis: variations in clinical and histopathologic changes in candidiasis compared with aspergillosis. Am J Ophthalmol. 2001;132(2):244–51.

    Article  CAS  PubMed  Google Scholar 

  • Riddell J, Comer GM, Kauffman CA. Treatment of endogenous fungal endophthalmitis: focus on new antifungal agents. Clin Infect Dis. 2011;52(5):648–53. doi:10.1093/cid/ciq204. Epub 2011 Jan 16.

    Article  CAS  PubMed  Google Scholar 

  • Shen X, Xu G. Vitrectomy for endogenous fungal endophthalmitis. Ocul Immunol Inflamm. 2009;17(3):148–52. doi:10.1080/09273940802689396.

    Article  PubMed  Google Scholar 

  • Smiddy WE. Treatment outcomes of endogenous fungal endophthalmitis. Curr Opin Ophthalmol. 1998;9(3):66–70.

    Article  CAS  PubMed  Google Scholar 

  • Stern WH, Tamura E, Jacobs RA, Pons VG, Stone RD, O’Day DM, Irvine AR. Epidemic postsurgical Candida parapsilosis endophthalmitis. Clinical findings and management of 15 consecutive cases. Ophthalmology. 1985;92(12):1701–9.

    Article  CAS  PubMed  Google Scholar 

  • Vaziri K, Schwartz SG, Kishor K, Flynn Jr HW. Endophthalmitis: state of the art. Clin Ophthalmol. 2015;9:95–108. doi:10.2147/OPTH.S76406. eCollection 2015.

    PubMed  PubMed Central  Google Scholar 

  • Weissgold DJ, D’Amico DJ. Rare causes of endophthalmitis. Int Ophthalmol Clin. 1996;36(3):163–77.

    Article  CAS  PubMed  Google Scholar 

  • Wykoff CC, Flynn HW Jr, Miller D, Scott IU, Alfonso EC. Exogenous fungal endophthalmitis: microbiology and clinical outcomes. Ophthalmology. 2008;115(9):1501–7, 1507.e1–2. doi:10.1016/j.ophtha.2008.02.027.

    Google Scholar 

  • Zhang YQ, Wang WJ. Treatment outcomes after pars plana vitrectomy for endogenous endophthalmitis. Retina. 2005;25(6):746–50.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alessandro Invernizzi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer India

About this entry

Cite this entry

Invernizzi, A. (2016). Fungal Endophthalmitis. In: Gupta, V., Nguyen, Q., LeHoang, P., Herbort Jr., C. (eds) The Uveitis Atlas. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2506-5_19-1

Download citation

  • DOI: https://doi.org/10.1007/978-81-322-2506-5_19-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New Delhi

  • Online ISBN: 978-81-322-2506-5

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics