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Application of Ionic Liquids in Extraction and Separation of Biological Samples

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Encyclopedia of Ionic Liquids

Introduction

Room temperature ionic liquids (ILs) are stable liquids composed of anions and cations. ILs are new advanced materials with potential use in various fields of modern chemistry and technology. Compared with conventional organic solvents, ILs have low vapor pressure, good chemical stability, strong designability, and good solubility for organic and inorganic substances. Driven by “green chemistry,” ILs are widely used in the extraction technology to concentrate and separate the substances to be tested. Provided herein are the extraction and separation of trace metal ions, drugs, and other organic matters in a variety of biological samples. ILs based extraction can reduce the interference of the complex matrix, simplify the analysis procedure, and save time. Therefore, ionic liquid, as adsorbent of solid phase extraction or extractant of liquid phase extraction, is widely used to separate and concentrate environmental pollutants like metal ions and pesticide, biomolecules...

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References

  1. Lv YT, Ji JG, Xia ZN et al (2010) Progress in room temperature ionic liquids for extraction of organic compounds. Chem Ind Eng Prog 29(5):801–806

    Google Scholar 

  2. Yu YY, Zhang W, Cao S (2007) Extraction of ferulic acid and caffeic acid with ionic liquids. Chin J Ana1 Chem 35(12):1726–1730

    Google Scholar 

  3. Zhao Q, Fang F, Liang Y et al (2014) 1-Dodecyl-3-methylimidazolium chloride-assisted sample preparation method for efficient integral membrane proteome analysis. Anal Chem 86(15):7544–7550

    Google Scholar 

  4. Talpur S, Kazi TG, Afridi HI et al (2018) Ultrasonically dispersed ionic liquid-based microextraction of lead in biological samples of malnourished children prior to analysis by flame atomic absorption spectrometry. J AOAC Int 101(3):883–890

    Google Scholar 

  5. Fang GZ, Lu JP, Zhang J (2010) Preparation, characterization, and application of a new thiol-functionalized ionic liquid for highly selective extraction of Cd(II). Mikrochim Acta 171(3/4):305–311

    Google Scholar 

  6. Wan H, Huang DY, Cai Y et al (2008) Extraction of phenolic compounds with [omim]BF4 ionic liquid. J Chem Eng Chin Univ 22(2):162–165

    Google Scholar 

  7. Vidal L, Chisvert A, Canals A et al (2007) Sensitive determination of free benzophenone-3 in human urine samples based on an ionic liquid as extractant phase in single-drop microextraction prior to liquid chromatography analysis. J Chromatogr A 1174(1–2):95–103

    Google Scholar 

  8. Tian J, Chen X, Bai X (2015) Comparison of dispersive liquid-liquid microextraction based on organic solvent and ionic liquid combined with high-performance liquid chromatography for the analysis of emodin and its metabolites in urine samples. J Sep Sci 35(1):145–152

    Google Scholar 

  9. Qi XR, Zhou HM, Lv P et al (2013) Determination of bromadiolone in plasma by ionic liquid dispersive liquid-liquid microextraction and high performance liquid chromatograph. Chin J Forensic Med 28(4):281–284

    Google Scholar 

  10. Xu X, Su R, Zhao X et al (2011) Ionic liquid-based microwave-assisted dispersive liquid-liquid microextraction and derivatization of sulfonamides in river water, honey, milk, and animal plasma. Anal Chim Acta 707(1–2):92–99

    Google Scholar 

  11. Berton P, Martinis EM, Wuilloud RG (2010) Development of an on-line temperature-assisted ionic liquid dispersive microextraction system for sensitive determination of vanadium in environmental and biological samples. J Hazard Mater 176(1–3):721–728

    Google Scholar 

  12. Stanisz E, Werner J, Matusiewicz H (2013) Mercury species determination by task specific ionic liquid-based ultrasound-assisted dispersive liquid–liquid microextraction combined with cold vapour generation atomic absorption spectrometry. Microchem J 110:28–35

    Google Scholar 

  13. Zhang H, Cheng M, Jiang X (2010) Determination of benzoic acid in water samples by ionic liquid cold-Induced aggregation dispersive LLME coupling with LC. Chromatographia 72:1195–1119

    Google Scholar 

  14. Majidi B, Shemirani F (2011) In situ solvent formation microextraction in the presence of ionic liquid for preconcentration and speciation of arsenic in saline samples and total arsenic in biological samples by electrothermal atomic absorption spectrometry. Biol Trace Elem Res 143(1):579–590

    Google Scholar 

  15. Paula B, Romina PM, Rodolfo GW (2012) Selective extraction and determination of vitamin B12 in urine by ionic liquid-based aqueous two-phase system prior to high-performance liquid chromatography. Talanta 97:521–526

    Google Scholar 

  16. Pereira MM, Pedro SN, Quental MV et al (2015) Enhanced extraction of bovine serum albumin with aqueous biphasic systems of phosphonium- and ammonium-based ionic liquids. J Biotechnol 206:17–25

    Google Scholar 

  17. Zhuang R, Zhao SM, Bi KS et al (2014) Progress of application of ionic liquid in extraction and separation of biological samples. Chin Pharm J 49(14):1181–1184

    Google Scholar 

  18. Shirkhanloo H, Karamzadeh Z, Rakhtshah J et al (2019) A novel biostructure sorbent based on CysSB/MetSB@MWCNTs for separation of nickel and cobalt in biological samples by ultrasound assisted-dispersive ionic liquid-suspension solid phase micro extraction. J Pharm Biomed Anal 172:285–294

    Google Scholar 

  19. Yang Q, Wang Y, Zhang H et al (2017) A novel dianionic amino acid ionic liquid-coated PEG 4000 modified Fe3O4 nanocomposite for the magnetic solid-phase extraction of trypsin. Talanta 174:139–147

    Google Scholar 

  20. Liu YM, Tian W, Jia YX et al (2010) The use of CE ECL with ionic liquid for the determination of drug alkaloids and applications in human urine. Electrophoresis 30(8):1406–1411

    Google Scholar 

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Correspondence to Liyun Kong .

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Kong, L., Li, X., Gao, Q. (2021). Application of Ionic Liquids in Extraction and Separation of Biological Samples. In: Zhang, S. (eds) Encyclopedia of Ionic Liquids. Springer, Singapore. https://doi.org/10.1007/978-981-10-6739-6_145-1

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  • DOI: https://doi.org/10.1007/978-981-10-6739-6_145-1

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  • Print ISBN: 978-981-10-6739-6

  • Online ISBN: 978-981-10-6739-6

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