Skip to main content
SpringerLink
Log in

Biocatalysis in Ionic Liquids

  • Living reference work entry
  • First Online:
Encyclopedia of Ionic Liquids

Introduction

Ionic liquids (ILs) are organic salts that exist as liquid at or close to room temperature. The unique physicochemical properties of ILs, such as negligible volatility, thermal stability, and relatively high polarity, make them interesting solvents for biocatalytic process. ILs are generally considered as green solvents that are good substitutes for traditional organic solvents. Also, ILs have been described as “designer solvents,” owing to their widely tunable physicochemical properties in terms of viscosity, density, hydrophobicity, polarity, and solvent miscibility by a suitable combination of different cations and anions (Fig. 1).

Fig. 1
figure 1

Examples of common cations and anions used in ILs

Full size image

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  1. Cull SG, Holbrey JD, Vargas-Mora V, Seddon KR, Lye GJ (2000) Room-temperature ionic liquids as replacements for organic solvents in multiphase bioprocess operations. Biotechnol Bioeng 69(2):227–233

    Google Scholar 

  2. Erbeldinger M, Mesiano AJ, Russell AJ (2000) Enzymatic catalysis of formation of Z-aspartame in ionic liquid − an alternative to enzymatic catalysis in organic solvents. Biotechnol Prog 16(6):1129–1131

    Google Scholar 

  3. Madeira Lau R, van Rantwijk F, Seddon KR, Sheldon RA (2000) Lipase-catalyzed reactions in ionic liquids. Org Lett 2(26):4189–4191

    Google Scholar 

  4. Itoh T (2017) Ionic liquids as tool to improve enzymatic organic synthesis. Chem Rev 117(15):10567–10607

    Google Scholar 

  5. van Rantwijk F, Sheldon RA (2007) Biocatalysis in ionic liquids. Chem Rev 107(6):2757–2785

    Google Scholar 

  6. Hernández-Fernández FJ, de los Ríos AP, Tomás-Alonso F, Gómez D, Víllora G (2009) Kinetic resolution of 1-phenylethanol integrated with separation of substrates and products by a supported ionic liquid membrane. J Chem Technol Biotechnol 84(3):337–342

    Google Scholar 

  7. Drożdż A, Erfurt K, Bielas R, Chrobok A (2015) Chemo-enzymatic Baeyer–Villiger oxidation in the presence of Candida antarctica lipase B and ionic liquids. New J Chem 39(2):1315–1321

    Google Scholar 

  8. Eckstein M, Filho MV, Liese A, Kragl U (2004) Use of an ionic liquid in a two-phase system to improve an alcohol dehydrogenase catalyzed reduction. Chem Commun (9):1084–1085

    Google Scholar 

  9. Zhao H, Malhotra SV (2002) Enzymatic resolution of amino acid esters using ionic liquid N-ethyl pyridinium trifluoroacetate. Biotechnol Lett 24(15):1257–1259

    Google Scholar 

  10. Cerqueira Pereira S, Bussamara R, Marin G, Lima Camargo Giordano R, Dupont J, de Campos Giordano R (2012) Enzymatic synthesis of amoxicillin by penicillin G acylase in the presence of ionic liquids. Green Chem 14(11):3146–3156

    Google Scholar 

  11. Pfruender H, Amidjojo M, Kragl U, Weuster-Botz D (2004) Efficient whole-cell biotransformation in a biphasic ionic liquid/water system. Angew Chem Int Ed Engl 43(34):4529–4531

    Google Scholar 

  12. Xu P, Zheng GW, Du PX, Zong MH, Lou WY (2016) Whole-cell biocatalytic processes with ionic liquids. ACS Sustain Chem Eng 4(2):371–386

    Google Scholar 

  13. Lou WY, Wang W, Smith TJ, Zong MH (2009) Biocatalytic anti-Prelog stereoselective reduction of 4 '-methoxyacetophenone to (R)-1-(4-methoxyphenyl)ethanol with immobilized Trigonopsis variabilis AS2.1611 cells using an ionic liquid-containing medium. Green Chem 11(9):1377–1384

    Google Scholar 

  14. Kaar JL, Jesionowski AM, Berberich JA, Moulton R, Russell AJ (2003) Impact of ionic liquid physical properties on lipase activity and stability. J Am Chem Soc 125(14):4125–4131

    Google Scholar 

  15. Xiao ZJ, Du PX, Lou WY, Wu H, Zong MH (2012) Using water-miscible ionic liquids to improve the biocatalytic anti-Prelog asymmetric reduction of prochiral ketones with whole cells of Acetobacter sp. CCTCC M209061. Chem Eng Sci 84:695–705

    Article  CAS  Google Scholar 

  16. Abbott AP, Capper G, Davies DL, Munro HL, Rasheed RK, Tambyrajah V (2001) Preparation of novel, moisture-stable, Lewis-acidic ionic liquids containing quaternary ammonium salts with functional side chains. Chem Commun (19):2010–2011

    Google Scholar 

  17. Yang TX, Zhao LQ, Wang J, Song GL, Liu HM, Cheng H, Yang Z (2017) Improving whole-cell biocatalysis by addition of deep eutectic solvents and natural deep eutectic solvents. ACS Sustain Chem Eng 5(7):5713–5722

    Google Scholar 

  18. Xu P, Zheng GW, Zong MH, Li N, Lou WY (2017) Recent progress on deep eutectic solvents in biocatalysis. Bioresour Bioprocess 4:34

    Article  Google Scholar 

  19. Shi-Hui H, Hirakawa T, Fukuba T, Hayase S, Kawatsura M, Itoh T (2007) Synthesis of enantiomerically pure cycloalkenols via combination strategy of enzyme-catalyzed reaction and RCM reaction. Tetrahedron: Asymmetr 18(20):2484–2490

    Google Scholar 

  20. Lozano P, Diego Td, Carrié D, Vaultier M, Iborra JL (2002) Continuous green biocatalytic processes using ionic liquids and supercritical carbon dioxide. Chem Commun (7):692–693

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology, Guangdong, China

    Wen-Yong Lou & Pei Xu

Authors
  1. Wen-Yong Lou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pei Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wen-Yong Lou .

Editor information

Editors and Affiliations

  1. Institute of Process Engineering, Chinese Academy of Science, Institute of Process Engineering, Beijing, China

    Suojiang Zhang

Section Editor information

  1. Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China

    Buxing Han

  2. University of Chinese Academy of Sciences, Beijing, China

    Buxing Han

  3. University of Nottingham, Nottingham, UK

    Peter Licence

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Lou, WY., Xu, P. (2019). Biocatalysis in Ionic Liquids. In: Zhang, S. (eds) Encyclopedia of Ionic Liquids. Springer, Singapore. https://doi.org/10.1007/978-981-10-6739-6_77-1

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-6739-6_77-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-6739-6

  • Online ISBN: 978-981-10-6739-6

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

Publish with us

Policies and ethics

Search

Navigation