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Gastrointestinal Symptoms: Constipation, Diarrhea, and Intestinal Obstruction

Textbook of Palliative Care
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Abstract

Disturbed bowel function including constipation, diarrhoea and bowel obstructions, commonly affects palliative care patients. This chapter aims to summarise these problems focusing on the current understanding of the prevalence, aetiology and palliative management. The first issue that will be discussed is the most prevalent distal gut problem of constipation. Despite the fact that the majority of palliative care patients require laxatives, the aetiology of constipation in palliative care is not well described. The next topic is diarrhoea which although less common is still equally distressing. A systematic approach to assessment and management recommended. Lastly, the evidence that describes the palliative management of inoperable bowel obstructions will be explored.

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References

  • Addington-Hall J, Altmann D. Which terminally ill cancer patients in the United Kingdom receive care from community specialist palliative care nurses? J Adv Nurs. 2000;32(4):799–806.

    CAS  PubMed  Google Scholar 

  • Addington-Hall J, Altmann D, McCarthy M. Which terminally ill cancer patients receive hospice in-patient care? Soc Sci Med. 1998;46(8):1011–6.

    Article  CAS  Google Scholar 

  • Anon. Oxycodone-with-naloxone controlled-release tablets (Targin) for chronic severe pain. Radar. 2011.

    Google Scholar 

  • Anthony T, Baron T, Mercadante S, Green S, Chi D, Cunningham J, et al. Report of the clinical protocol committee: development of randomized trials for malignant bowel obstruction. J Pain Symptom Manage. 2007;34(Suppl 1):S49–59.

    Article  Google Scholar 

  • Arvieux C, Laval G, Stefani L, Villard ML, Mestrallet JP, Cardin N. Protocol for the treatment of malignant inoperable bowel obstruction: a prospective study of 80 cases at Grenoble University Hospital Center. J Pain Symptom Manage. 2006;31(6):502–12.

    Article  Google Scholar 

  • Bai J, Burckart G, Mulberg A. Literature review of gastrointestinal physiology in the elderly, in pediatric patients, and in patients with gastrointestinal diseases. J Pharm Sci. 2016;105(2):476–83.

    Article  CAS  Google Scholar 

  • Barr W, Smith A. Acute diarrhea in adults. Am Fam Physician. 2014;1(89):180–9.

    Google Scholar 

  • Beall D, Fortman B, Lawler B, Regan F. Imaging bowel obstruction: a comparison between fast magnetic resonance imaging and helical computed tomography. Clin Radiol. 2002;57(8):719–24.

    Article  CAS  Google Scholar 

  • Bell T, Panchal S, Miaskowski C, Bolge S, Milanova T, Williamson R. The prevalence, severity, and impact of opioid-induced bowel dysfunction: results of a US and European Patient Survey (PROBE 1). Pain Med. 2009;10(1):35–42.

    Article  Google Scholar 

  • Bharucha A, Fletcher J, Seide B, et al. Phenotypic variation in functional disorders of defecation. Gastroenterology. 2005;128:1199–210.

    Article  Google Scholar 

  • Bischoff K, Currow DC, Corvera C, Pantilat SZ. Unanswered questions in malignant bowel obstruction. J Palliat Care. 2015;30(4):265–70.

    Google Scholar 

  • Bjornsson E, Chey W, Hooper F, Woods M, Owyang C, Hasler W. Impaired gastrocolonic response and peristaltic reflex in slow-transit constipation: role of 5-HT(3) pathways. Am J Physiol Gastrointest Liver Physiol. 2002;283(2):G400–7.

    Article  CAS  Google Scholar 

  • Brandt L, Prather C, Quigley E, Schiller L, Schoenfeld P, Talley N. Systematic review on the management of chronic constipation in North America. Am J Gastroenterol. 2005;100(Suppl 1):S5–S21.

    Article  Google Scholar 

  • Chassany O, Michaux A, Bergmann JF. Drug-induced diarrhoea. Drug Saf. 2000;22(1):53–72.

    Article  CAS  Google Scholar 

  • Cherny NI. Evaluation and management of treatment-related diarrhea in patients with advanced cancer: a review. J Pain Symptom Manage. 2008;36(4):413–23.

    Article  CAS  Google Scholar 

  • Clark K, Currow DC. Constipation in palliative care: what do we use as definitions and outcome measures? J Pain Symptom Manage. 2013;45(4):753–62.

    Article  Google Scholar 

  • Clark K, Currow DC. Advancing research into symptoms of constipation at the end of life. Int J Palliat Nurs. 2014;20(8):370, 2.

    Article  Google Scholar 

  • Clark K, Lam L, Currow D. Reducing gastric secretions – a role for histamine 2 antagonists or proton pump inhibitors in malignant bowel obstruction? Support Care Cancer. 2009;17(12):1463–8.

    Article  CAS  Google Scholar 

  • Clark K, Currow DC, Talley NJ. The use of digital rectal examinations in palliative care inpatients. J Palliat Med. 2010;13(7):797.

    Article  Google Scholar 

  • Clark K, Smith JM, Currow DC. The prevalence of bowel problems reported in a palliative care population. J Pain Symptom Manage. 2012;43(6):993–1000.

    Article  Google Scholar 

  • Clark K, Lam L, Currow D, Agar M. A prospective study to investigate contributory factors that lead to constipation in palliative care patients. J Pain Symptom Manage. 2014;47(6):e1–4.

    Article  Google Scholar 

  • Clark K, Lam L, Talley NJ, Phillips JL, Currow DC. Identifying factors that predict worse constipation symptoms in palliative care patients: a secondary analysis. J Palliat Med. 2016a;(3):e1–3.

    Google Scholar 

  • Clark K, Lam L, Talley N, Quinn J, Blight A, Byfieldt N, et al. Assessing the presence and severity of constipation with plain radiographs in constipated palliative care patients. J Palliat Med. 2016b;19(6):617–21.

    Article  Google Scholar 

  • Clemens K, Faust M, Jaspers B, Mikus G. Pharmacological treatment of constipation in palliative care. Curr Opin Support Palliat Care. 2013;7(2):183–91.

    Article  Google Scholar 

  • Coffin B, Causse C. Constipation assessment scales in adults: a literature review including the new Bowel Function Index. Expert Rev Gastroenterol Hepatol. 2011;5(5):601–13.

    Article  Google Scholar 

  • Currow DC, Quinn S, Agar M, Fazekas B, Hardy J, McCaffrey N, et al. Double-blind, placebo-controlled, randomized trial of octreotide in malignant bowel obstruction. J Pain Symptom Manage. 2005;49(5):814–21.

    Article  Google Scholar 

  • Currow DC, Clark K, Kamal A, Collier A, Agar MR, Lovell MR, et al. The population burden of chronic symptoms that substantially predate the diagnosis of a life-limiting illness. J Palliat Med. 2015;18(6):480–5.

    Article  Google Scholar 

  • DeEulis TG, Yennurajalingam S. Venting gastrostomy at home for symptomatic management of bowel obstruction in advanced/recurrent ovarian malignancy: a case series. J Palliat Med. 2015;18(8):722–8.

    Article  Google Scholar 

  • Dobben A, Terra M, Deutekom M, Gerhards MF, Bijnen AB, Felt-Bersma RJ, et al. Anal inspection and digital rectal examination compared to anorectal physiology tests and endoanal ultrasonography in evaluating fecal incontinence. Int J Colorectal Dis. 2007;22:783–90.

    Article  Google Scholar 

  • Dolan EA. Malignant bowel obstruction: a review of current treatment strategies. Am J Hosp Palliat Med. 2011;28(8):576–82.

    Article  Google Scholar 

  • DuPont HL. Persistent diarrhea: a clinical review. JAMA. 2016;315(24):2712–23.

    Article  CAS  Google Scholar 

  • Dy SM. Enteral and parenteral nutrition in terminally ill cancer patients: a review of the literature. Am J Hosp Palliat Med. 2006;23(5):369–77.

    Article  Google Scholar 

  • Erichsen E, Milberg A, Jaarsma T, Friedrichsen M. Constipation in specialized palliative care: prevalence, definition, and patient-perceived symptom distress. J Palliat Med. 2015;18(7):585–92.

    Article  Google Scholar 

  • Fallon M, O’Neill B. ABC of palliative care. Constipation and diarrhoea. BMJ. 1997;315(7118):1293–6.

    Article  CAS  Google Scholar 

  • Faria M, Pavin E, Parisi M, Lorena S, Brunetto S, Ramos C, et al. Delayed small intestinal transit in patients with long-standing type 1 diabetes mellitus: investigation of the relationships with clinical features, gastric emptying, psychological distress, and nutritional parameters. Diabetes Technol Ther. 2013;15(1):32–8.

    Article  CAS  Google Scholar 

  • Ferguson HJM, Ferguson CI, Speakman J, Ismail T. Management of intestinal obstruction in advanced malignancy. Ann Med Surg. 2015;4:264–70.

    Article  Google Scholar 

  • Fischer M, Fadda H. The effect of sex and age on small intestinal transit times in humans. J Pharm Sci. 2016;105(2):682–6.

    Article  CAS  Google Scholar 

  • Folden SL. Practice guidelines for the management of constipation in adults. Rehabil Nurs. 2002;27(5):169–75. Rehabilition Nursing. 2002;27(5):169–70.

    Article  Google Scholar 

  • Folkert IW, Roses RE. Value in palliative cancer surgery: a critical assessment. J Surg Oncol. 2016;114(3):311–5.

    Article  Google Scholar 

  • Fosnes G, Lydersen S, Farup P. Constipation and diarrhoea – common adverse drug reactions? A cross sectional study in the general population. BMC Clin Pharmacol. 2011;11:2.

    Article  Google Scholar 

  • Frago R, Ramirez E, Millan M, Kreisler E, del Valle E, Biondo S. Current management of acute malignant large bowel obstruction: a systematic review. Am J Surg. 2015;207(1):127–38.

    Article  Google Scholar 

  • Gale AR, Wilson M. Diarrhea: initial evaluation and treatment in the emergency department. Emerg Med Clin North Am. 2016;34(2):293–308.

    Article  Google Scholar 

  • Gwilliam B, Bailey C. The nature of terminal malignant bowel obstruction and its impact on patients with advanced cancer. Int J Palliat Nurs. 2007;7(10):474–81.

    Article  Google Scholar 

  • Hawley P, Byeon J. A comparison of sennosides-based bowel protocols with and without docusate in hospitalized patients with cancer. J Palliat Med. 2008;11(4):575–81.

    Article  Google Scholar 

  • Hawley P, Barwich D, Kirk L. Implementation of the Victoria Bowel Performance Scale. J Pain Symptom Manage. 2011;42(6):946–53.

    Article  Google Scholar 

  • Hong SP, Kim TI. Colorectal stenting: an advanced approach to malignant colorectal obstruction. World J Gastroenterol. 2014;20(43):16020–8.

    Article  Google Scholar 

  • Hsieh C. Treatment of constipation in older adults. Am Fam Physician. 2005;2(11):2277–84.

    Google Scholar 

  • Izumi K. The measures to evaluate constipation: a review article. Gastroenterol Nurs. 2014;37(2):137–46.

    Article  Google Scholar 

  • Juckett G, Trivedi R. Evaluation of chronic diarrhea. Am Fam Physician. 2011;84(10):1119–26.

    PubMed  Google Scholar 

  • Kamal AH, Nipp RD, Bull J, Stinson CS, Abernethy AP. Symptom burden and performance status among community-dwelling patients with serious illness. J Palliat Med. 2015;18(6):542–4.

    Article  Google Scholar 

  • Kaneishi K, Kawabata M, Morita T. Olanzapine for the relief of nausea in patients with advanced cancer and incomplete bowel obstruction. J Pain Symptom Manage. 2012;44(4):604–7.

    Article  CAS  Google Scholar 

  • Kaplan J, Strongin A, Adler DG, Siddiqui AA. Enteral stents for the management of malignant colorectal obstruction. World J Gastroenterol. 2014;20(37):13239–45.

    Article  Google Scholar 

  • Kim EJ, Kim YJ. Stents for colorectal obstruction: past, present, and future. World J Gastroenterol. 2016;22(2):842–52.

    Article  CAS  Google Scholar 

  • Kim Y, Song B, Oh J, Woo S. Aerobic exercise improves gastrointestinal motility in psychiatric inpatients. World J Gastroenterol. 2014;20(30):10577–84.

    Article  Google Scholar 

  • Kim-Sing A, Yoshida EM, Whittaker JS. Palliative high-dose octreotide in a case of severe AIDS-related diarrhea. Ann Pharmacother. 1994;28(6):806–7.

    Article  CAS  Google Scholar 

  • Kubota H, Taguchi K, Kobayashi D, Naruyama H, Hirose M, Fukuta K, et al. Clinical impact of palliative treatment using octreotide for inoperable malignant bowel obstruction caused by advanced urological cancer. Asian Pac J Cancer Prev. 2013;14(12):7107–10.

    Article  Google Scholar 

  • Kucukmetin A, Naik R, Galaal K, Bryant A, Dickinson HO. Palliative surgery versus medical management for bowel obstruction in ovarian cancer. Cochrane Database Syst Rev. 2010;7:CD007792.

    Google Scholar 

  • Lamy O, Jenzer-Closuit A, Burckhardt P. Hypercalcaemia of malignancy: an undiagnosed and undertreated disease. J Intern Med. 2001;250(1):73–9.

    Article  CAS  Google Scholar 

  • Laugsand EA, Kaasa S, de Conno F, Hanks G, Klepstad P, Research Steering Committee of the EAPC. Intensity and treatment of symptoms in 3,030 palliative care patients: a cross-sectional survey of the EAPC Research Network. J Opioid Manag. 2009;5(1):11–21.

    Article  Google Scholar 

  • Lee C, Vather R, O’Callaghan A, Robinson J, McLeod B, Findlay M, et al. Validation of the phase II feasibility study in a palliative care setting: gastrografin in malignant bowel obstruction. Am J Hosp Palliat Med. 2012;30(8):752–8.

    Article  Google Scholar 

  • Leroi AM, Lalaude O, Antonietti M, Touchais JY, Ducrotte P, Menard JF, et al. Prolonged stationary colonic motility recording in seven patients with severe constipation secondary to antidepressants. Neurogastroenterol Motil. 2000;12(2):149–54.

    Article  CAS  Google Scholar 

  • Lynch M, Dahlin C, Bakitas M. Bowel obstruction and delirium: managing difficult symptoms at the end of life. Clin J Oncol Nurs. 2012;16(4):391–8.

    Article  Google Scholar 

  • McMillan S, Williams F. Validity and reliability of the constipation assessment scale. Cancer Nurs. 1989;12:183–8.

    Article  CAS  Google Scholar 

  • Mercadante S, Ferrera P, Villari P, Marrazzo A. Aggressive pharmacologic treatment for reversing malignant bowel obstruction. J Pain Symptom Manage. 2004;28(4):412–6.

    Article  Google Scholar 

  • Mercadante S, Ferrera P, Adile C. High doses of oxycodone-naloxone combination may provide poor analgesia. Support Care Cancer. 2011;19(9):1471–12.

    Article  Google Scholar 

  • Muller-Lissner S, Kamm M, Scarpignato C, Wald A. Myths and misconceptions about chronic constipation. Am J Gastroenterol. 2005;100(1):232–42.

    Article  Google Scholar 

  • Nelson A, Camilleri M. Chronic opioid-induced constipation in patients with nonmalignant pain: challenges and opportunities. Ther Adv Gastroenterol. 2015;8(4):206–20.

    Article  Google Scholar 

  • O’Connor B, Creedon B. Pharmacological treatment of bowel obstruction in cancer patients. Expert Opin Pharmacother. 2011;12(14):2205–14.

    Article  Google Scholar 

  • Paul Olson TJ, Pinkerton C, Brasel KJ, Schwarze ML. Palliative surgery for malignant bowel obstruction from carcinomatosis: a systematic review. JAMA Surg. 2014;149(4):383–92.

    Article  Google Scholar 

  • Peck JJ, Milleson T, Phelan J. The role of computed tomography with contrast and small bowel follow-through in management of small bowel obstruction. Am J Surg. 1999;177:375–8.

    Article  CAS  Google Scholar 

  • Pitlick M, Fritz D. Evidence about the pharmacological management of constipation. Part 2: implications for palliative care. Home Healthc Nurse. 2013;31(4):207–16.

    Article  Google Scholar 

  • Prichard D, Norton C, Bharucha AE. Management of opioid-induced constipation. Br J Nurs. 2016;25(10):S4–5, S8–11.

    Article  Google Scholar 

  • Prommer E. Anticholinergics in palliative medicine: an update. Am J Hosp Palliat Med. 2013;30(5):490–8.

    Article  Google Scholar 

  • Quigley EM, Neshatian L. Advancing treatment options for chronic idiopathic constipation. Expert Opin Pharmacother. 2016;17(4):501–11.

    Article  CAS  Google Scholar 

  • Ragno A, Pepe J, Badiali D, Minisola S, Romagnoli E, Severi C, et al. Chronic constipation in hypercalcemic patients with primary hyperparathyroidism. Eur Rev Med Pharmacol Sci. 2012;16(7):884–9.

    CAS  PubMed  Google Scholar 

  • Rahman Q, Haboubi NY, Hudson PR, Lee GS, Shah IU. The effect of thyroxine on small intestinal motility in the elderly. Clin Endocrinol (Oxf). 1991;35(5):443–6.

    Article  CAS  Google Scholar 

  • Rao S, Sadeghi P, Beaty J, Kavlock R, Ackerson K. Ambulatory 24-h colonic manometry in healthy humans. Am J Physiol Gastrointest Liver Physiol. 2001;280:629–39.

    Article  Google Scholar 

  • Rentz A, Yu R, Muller-Lissner S, Leyendecker P. Validation of the Bowel Function Index to detect clinically meaningful changes in opioid-induced constipation. J Med Econ. 2009;12:371–83.

    Article  CAS  Google Scholar 

  • Ripamonti C. Role of octreotide, scopolamine butylbromide, and hydration in symptom control of patients with inoperable bowel obstruction and nasogastric tubes: a prospective randomized trial. J Pain Symptom Manage. 2000;19(1):23–4.

    Article  CAS  Google Scholar 

  • Ripamonti C, Easson AM, Gerdes H. Management of malignant bowel obstruction. Eur J Cancer. 2008;44(8):1105–15.

    Article  Google Scholar 

  • Roeland E, von Gunten C. Current concepts in malignant bowel obstruction management. Curr Oncol Rep. 2007;4(11):298–303.

    Google Scholar 

  • Saad R, Rao S, Koch K, Kuo B, Parkman H, McCallum R, et al. Do stool form and frequency correlate with whole-gut and colonic transit? Results from a multicenter study in constipated individuals and healthy controls. Am J Gastroenterol. 2010;105(2):403–11.

    Article  Google Scholar 

  • Sbahi H, Cash BD. Chronic constipation: a review of current literature. Curr Gastroenterol Rep. 2015;17:47.

    Article  Google Scholar 

  • Slappendel R, Simpson K, Dubois D, Keininger D. Validation of the PAC-SYM questionnaire for opioid-induced constipation in patients with chronic low back pain. Eur J Pain. 2006;10:209–17.

    Article  Google Scholar 

  • Soriano A, Davis MP. Malignant bowel obstruction: individualized treatment near the end of life. Cleve Clin J Med. 2011;78(3):197–206.

    Article  Google Scholar 

  • Spinzi G, Amato A, Imperiali G, Lenoci N, Mandelli G, Paggi S, et al. Constipation in the elderly: management strategies. Drugs Aging. 2009;26(6):469–74.

    Article  CAS  Google Scholar 

  • Sweetser S. Evaluating the patient with diarrhea: a case-based approach. Mayo Clin Proc. 2012;87(6):596–602.

    Article  Google Scholar 

  • Talley NJ. How to do and interpret a rectal examination in gastroenterology. Am J Gastroenterol. 2008;103:820–2.

    Article  Google Scholar 

  • Thompson WM, Kilani RK, Smith BB, Thomas J, Jaffe TA, Delong DM, et al. Accuracy of abdominal radiography in acute small-bowel obstruction: does reviewer experience matter? Am J Roentgenol. 2007;188(3):233–8.

    Article  Google Scholar 

  • Tuca A, Guell E, Martinez-Losada E, Codorniu N. Malignant bowel obstruction in advanced cancer patients: epidemiology, management, and factors influencing spontaneous resolution. Cancer Manag Res. 2012;4:159–69.

    Article  Google Scholar 

  • Vazquez RM, Bouras PE. Epidemiology and management of chronic constipation in elderly patients. Clin Interv Aging. 2015;10:919–30.

    Google Scholar 

  • Wald A. Constipation: pathophysiology and management. Curr Opin Gastroenterol. 2015;31(1):45–9.

    Article  CAS  Google Scholar 

  • Wald A. Constipation advances in diagnosis and treatment. JAMA. 2016;315(2):185–91.

    Article  CAS  Google Scholar 

  • Wee B, Adams A, Thompson K, Percival F, Burslem K, Jobanputra M. How much does it cost a specialist palliative care unit to manage constipation in patients receiving opioid therapy? J Pain Symptom Manage. 2010;39(4):644–54.

    Article  Google Scholar 

  • Whitworth M, Whitfield A, Holm S, Shaffer J, Makin W, Jayson G. Doctor, does this mean I’m going to starve to death? J Clin Oncol. 2004;22:199–20.

    Article  Google Scholar 

  • Wu M, Chang C, Cheng C, Chen C, Lee W, Hsu Y, et al. Colonic transit time in long-term dialysis patients. Am J Kidney Dis. 2004;44(2):322–7.

    Article  Google Scholar 

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Clark, K. (2018). Gastrointestinal Symptoms: Constipation, Diarrhea, and Intestinal Obstruction. In: MacLeod, R., van den Block, L. (eds) Textbook of Palliative Care. Springer, Cham. https://doi.org/10.1007/978-3-319-31738-0_14-1

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  1. Latest

    Constipation, Diarrhea, and Intestinal Obstruction in Palliative Care
    Published:
    09 December 2023

    DOI: https://doi.org/10.1007/978-3-319-31738-0_14-2

  2. Original

    Gastrointestinal Symptoms: Constipation, Diarrhea, and Intestinal Obstruction
    Published:
    28 March 2018

    DOI: https://doi.org/10.1007/978-3-319-31738-0_14-1